FUT2

FUT2
식별자
별칭	FUT2, B12QTL1, SE, SEC2, Se2, Sej, fucosyl transferase 2
외부 ID	OMIM: 182100 MGI: 109374 HomoloGene: 10325 GeneCard: FUT2
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	48,705,951 bp
유전자 위치(마우스)
쳇.	7번 염색체(쥐)
끝	45,315,818 bp
RNA 표현 패턴
	표현된 상단
	경조 침샘; ; 십이지장; ; 침샘; ; 뱃속; ; 질질 끌다; ; 구강;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	전이효소 활동; 갈락토사이드 2-알파-L-푸코실전달효소 활성; 글리코실전달효소 활성; 후코실전달효소 활동;
셀룰러 컴포넌트	막의 적분 성분; 골지 시스테나 막; 골지 기구; 세포외 외성체; 막으로 막다;
생물학적 과정	단백질 당화; L-푸코오스 카타볼라 공정; 푸코실화; 탄수화물 대사 과정;
	출처:아미고 / 퀵고
직교체
	2524
	14344
	ENSG00000176920
	ENSMUSG00000055978
	Q10981
	Q9JL27
	NM_001097638; NM_000511
	NM_001271993; NM_018876
	NP_000502; NP_001091107
	NP_001258922; NP_061364
	위키다타
인간 보기/편집	마우스 보기/편집

갈락토사이드 2-알파-L-푸코실전달효소 2는 인간에서 FUT2 유전자에 의해 인코딩되는 효소다.^[5]^[6]그것은 ABO 항원의 분비기관 지위에 영향을 미친다.^[7]

백인 중 약 20%는 FUT2의 G428A(rs601338)와 C571T(rs492602?)의 난센스 돌연변이로 인해 비보안관이므로 노로바이러스 GII.4로부터 절대적으로 보호되지는 않지만 강점을 가지고 있다.^{[citation needed]}

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000176920 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000055978 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.
^ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".
^ "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Retrieved 2019-10-13.

추가 읽기

Reguigne-Arnould I; Couillin P; Mollicone R; et al. (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenet. Cell Genet. 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588.
Rouquier S; Lowe JB; Kelly RJ; et al. (1995). "Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus". J. Biol. Chem. 270 (9): 4632–9. doi:10.1074/jbc.270.9.4632. PMID 7876234.
Kelly RJ; Rouquier S; Giorgi D; et al. (1995). "Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype". J. Biol. Chem. 270 (9): 4640–9. doi:10.1074/jbc.270.9.4640. PMID 7876235.
Kudo T; Iwasaki H; Nishihara S; et al. (1996). "Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals". J. Biol. Chem. 271 (16): 9830–7. doi:10.1074/jbc.271.16.9830. PMID 8621666.
Koda Y, Soejima M, Liu Y, Kimura H (1996). "Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency". Am. J. Hum. Genet. 59 (2): 343–50. PMC 1914724. PMID 8755920.
Koda Y, Soejima M, Wang B, Kimura H (1997). "Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)". Eur. J. Biochem. 246 (3): 750–5. doi:10.1111/j.1432-1033.1997.t01-1-00750.x. PMID 9219535.
Koda Y; Soejima M; Johnson PH; et al. (1997). "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". Biochem. Biophys. Res. Commun. 238 (1): 21–5. doi:10.1006/bbrc.1997.7232. PMID 9299444.
Liu Y; Koda Y; Soejima M; et al. (1998). "Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa". Hum. Genet. 103 (2): 204–10. doi:10.1007/s004390050808. PMID 9760207. S2CID 25253767.
Domino SE, Zhang L, Lowe JB (2001). "Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract". J. Biol. Chem. 276 (26): 23748–56. doi:10.1074/jbc.M100735200. PMID 11323419.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Milland J; Russell SM; Dodson HC; et al. (2002). "The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme". J. Biol. Chem. 277 (12): 10374–8. doi:10.1074/jbc.M111799200. PMID 11777923.
Chang JG; Ko YC; Lee JC; et al. (2002). "Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation". J. Hum. Genet. 47 (2): 60–5. doi:10.1007/s100380200001. PMID 11916003.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lindesmith L; Moe C; Marionneau S; et al. (2003). "Human susceptibility and resistance to Norwalk virus infection". Nat. Med. 9 (5): 548–53. doi:10.1038/nm860. PMID 12692541. S2CID 28663420.
Guo ZH; Xiang D; Zhu ZY; et al. (2004). "[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21 (5): 417–21. PMID 15476160.
Chen DP; Tseng CP; Wang WT; et al. (2005). "Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese". Ann. Clin. Lab. Sci. 34 (3): 314–8. PMID 15487706.
Pang H, Soejima M, Koda Y, Kimura H (2005). "A novel tetrameric short tandem repeat located in the 3' flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci". Hum. Biol. 76 (5): 789–95. doi:10.1353/hub.2005.0008. PMID 15757249. S2CID 1201579.
Madjd Z; Parsons T; Watson NF; et al. (2006). "High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas". Breast Cancer Res. 7 (5): R780–7. doi:10.1186/bcr1305. PMC 1242157. PMID 16168124.
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

19번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000176920 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000055978 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1763885-5] Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.

[entrez-6] "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".

[7] "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Retrieved 2019-10-13.

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