다파장 이상분산

다파장 변칙적 회절(다파장 변칙적 분산, 약칭 MAD)은 위상 문제의 용액을 통해 생물학적 고분자(예: DNA, 약물 수용체)의 3차원 구조를 쉽게 결정하는 X선 결정학에 사용되는 기법이다.^[1]

MAD는 웨인 헨드릭슨이 미국 해군 연구소에서 제롬 칼 밑에서 박사후 연구원으로 일하면서 개발했다.^[2]MAD(및 창제자 단일 파장 변칙 분산)가 바탕이 된 수학은 1985년 노벨 화학상(허버트 하우프트만과 함께)을 받은 제롬 칼레(Jerome Karle)에 의해 개발되었다.

참고 항목

참조

^ Hendrickson W, Ogata C (1997). "Phase determination from multiwavelength anomalous diffraction measurements". Methods in Enzymology. 276: 494–523. doi:10.1016/S0076-6879(97)76074-9. ISBN 978-0-12-182177-7. PMID 27799111.
^ Hendrickson WA (1985). "Analysis of Protein Structure from Diffraction Measurement at Multiple Wavelengths". Transactions of the ACA. 21.

추가 읽기

Hendrickson WA (1985). "Analysis of Protein Structure from Diffraction Measurement at Multiple Wavelengths". Transactions of the ACA. 21.
Karle J (1980). "Some Developments in Anomalous Dispersion for the Structural Investigation of Macromolecular Systems in Biology". International Journal of Quantum Chemistry: Quantum Biology Symposium. 7: 357–367. doi:10.1002/qua.560180734.
Karle J (1989). "Linear Algebraic Analyses of Structures with One Predominant Type of Anomalous Scatterer". Acta Crystallographica A. 45 (4): 303–307. doi:10.1107/s0108767388013042. PMID 2559755.
Pahler A, Smith JL, Hendrickson WA (1990). "A Probability Representation for Phase Information from Multiwavelength Anomalous Dispersion". Acta Crystallographica A. 46 (7): 537–540. doi:10.1107/s0108767390002379.
Terwilliger TC (1994). "MAD Phasing: Bayesian Estimates of FA". Acta Crystallographica D. 50: 11–16. doi:10.1107/s0907444993008224.
Terwilliger TC (1994). "MAD Phasing: Treatment of Dispersive Differences as Isomorphous Replacement Information". Acta Crystallographica D. 50 (Pt 1): 17–23. doi:10.1107/s0907444993008236. PMID 15299472.
Fourme R, Shepard W, Kahn R, l'Hermite G, de La Sierra IL (1995). "The Multiwavelength Anomalous Solvent Contrast (MASC) Method in Macrocolecular Crystallography". Journal of Synchrotron Radiation. 2 (Pt 1): 36–48. doi:10.1107/S0909049594006680. PMID 16714785.
de la Fortelle E, Bricogne G (1997). "Maximum-Likelihood Heavy-Atom Parameter Refinement for Multiple Isomorphous Replacement and Multiwavelength Anomalous Diffraction Methods". Methods in Enzymology. 276: 472–494. doi:10.1016/S0076-6879(97)76073-7. ISBN 978-0-12-182177-7. PMID 27799110. {{cite journal}}:Cite 저널은 필요로 한다. journal=(도움말)
Hendrickson WA, Ogata CM (1997). "Phase Determination from Multiwavelength Anomalous Diffraction Measurements". Methods in Enzymology. 276: 494–523. doi:10.1016/S0076-6879(97)76074-9. ISBN 978-0-12-182177-7. PMID 27799111. {{cite journal}}:Cite 저널은 필요로 한다. journal=(도움말)
Bella J, Rossmann MG (1998). "A General Phasing Algorithm for Multiple MAD and MIR Data". Acta Crystallographica D. 54 (2): 159–174. doi:10.1107/s0907444997010469. PMID 9761882.
Guss JM, Merritt EA, Phizackerley RP, Hedman B, Murata M, Hodgson KO, Freeman HC (1989). "Phase determination by multiple-wavelength X-ray diffraction: crystal structure of a basic blue copper protein from cucumbers". Science. 241 (4867): 806–811. Bibcode:1988Sci...241..806G. doi:10.1126/science.3406739. PMID 3406739.

외부 링크

컴퓨터 프로그램

SSRL 흡수 패키지 -
CHOOCH -
쉐이크 앤 베이크 (SnB) —
SELX -

자습서 및 예제

Evans, Gwyndaf (October 1994). "The method of Multiple wavelength Anomalous Diffraction using Synchrotron Radiation at optimal X-ray energies: Application to Protein Crystallography". PhD Thesis. University of Warwick.

[Hendrickson1997-1] Hendrickson W, Ogata C (1997). "Phase determination from multiwavelength anomalous diffraction measurements". Methods in Enzymology. 276: 494–523. doi:10.1016/S0076-6879(97)76074-9. ISBN 978-0-12-182177-7. PMID 27799111.

[Hendrickson1985-2] Hendrickson WA (1985). "Analysis of Protein Structure from Diffraction Measurement at Multiple Wavelengths". Transactions of the ACA. 21.

[1]

[2]

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