ACAT2

ACAT2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1 WL4, 1 WL5
식별자
에일리어스	ACAT2, 아세틸CoA아세틸전달효소2
외부 ID	OMIM: 100678 MGI: 87871 HomoloGene: 55855 GeneCard: ACAT2
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	159,779,112 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	13,176,634 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 핀; ; 간우엽; ; 랑게르한스 섬; ; 전전두피질; ; 정자; ; 난모세포; ; 직장; ; 브로드만 9구역; ; 이차 난모세포;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	트랜스페라아제 활성; 아실전달효소활성; 촉매 활성; GO:0001948, GO:0016582 단백질 결합; 아미노아실기 이외의기를 전이하는 아실전달효소 활성; 아세틸CoAC-아세틸전달효소활성; 아세틸CoAC-아실전달효소활성;
셀룰러 컴포넌트	세포질; 핵소체; 세포외 엑소좀; 핵; 미토콘드리아; 세포;
생물학적 과정	대사; 지질대사; 지방산β매개성; 콜레스테롤 생합성 과정;
	출처:아미고 / QuickGO
맞춤법
	39
	110460
	ENSG00000120437
	ENSMUSG000023832
	Q9BWD1
	Q8CAY6
	NM_005891; NM_001303253
	NM_009338
	NP_001290182; NP_005882
	NP_033364
	위키데이터
인간 보기/편집	마우스 표시/편집

아세틸-CoA 아세틸전달효소, 세포소성 아세틸-CoA 티올라아제라고도 알려진 세포소성 아세틸전달효소는 사람에게서 ACAT2(아세틸-Coenzyme A 아세틸전달효소^[5] 2) 유전자에 의해 암호화되는 효소이다.

아세틸-코엔자임 A 아세틸전달효소 2는 아세틸-CoA C-아세틸전달효소이다.

진

이 유전자는 생쥐와 사람 모두에서 TCP1 유전자의 3-프라임 영역과 상보적인 중복을 보인다.이 유전자들은 반대되는 전사 ^[5]방향뿐만 아니라 반대되는 DNA 가닥에 암호화됩니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000120437 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000023832 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: acetyl-Coenzyme A acetyltransferase 2".

외부 링크

UCSC Genome Browser의 인간 ACAT2 게놈 위치 및 ACAT2 유전자 세부 정보 페이지.

추가 정보

Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG (Jan 2008). "Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)". The Prostate. 68 (1): 20–33. doi:10.1002/pros.20674. PMID 18000807. S2CID 40860952.
Reynolds CA, Hong MG, Eriksson UK, Blennow K, Wiklund F, Johansson B, Malmberg B, Berg S, Alexeyenko A, Grönberg H, Gatz M, Pedersen NL, Prince JA (May 2010). "Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk". Human Molecular Genetics. 19 (10): 2068–78. doi:10.1093/hmg/ddq079. PMC 2860895. PMID 20167577.
He X, Lu Y, Saha N, Yang H, Heng CK (Dec 2005). "Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks". Human Genetics. 118 (3–4): 393–403. doi:10.1007/s00439-005-0055-3. PMID 16195894. S2CID 13637004.
Yamada Y, Matsuo H, Warita S, Watanabe S, Kato K, Oguri M, Yokoi K, Metoki N, Yoshida H, Satoh K, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y (Nov 2007). "Prediction of genetic risk for dyslipidemia". Genomics. 90 (5): 551–8. doi:10.1016/j.ygeno.2007.08.001. PMID 17919884.
Kursula P, Sikkilä H, Fukao T, Kondo N, Wierenga RK (Mar 2005). "High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I". Journal of Molecular Biology. 347 (1): 189–201. doi:10.1016/j.jmb.2005.01.018. PMID 15733928.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM (Dec 2008). "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations". Journal of Lipid Research. 49 (12): 2582–9. doi:10.1194/jlr.M800232-JLR200. PMID 18660489.
Parini P, Jiang ZY, Einarsson C, Eggertsen G, Zhang SD, Rudel LL, Han TQ, Eriksson M (Nov 2009). "ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients". Atherosclerosis. 207 (1): 266–71. doi:10.1016/j.atherosclerosis.2009.04.010. PMC 2784173. PMID 19467657.
Pramfalk C, Angelin B, Eriksson M, Parini P (Dec 2007). "Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells". Biochemical and Biophysical Research Communications. 364 (2): 402–9. doi:10.1016/j.bbrc.2007.10.028. PMID 17950700.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y (May 2009). "Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension". Hypertension Research. 32 (5): 411–8. doi:10.1038/hr.2009.22. PMID 19282863.
Matsumoto K, Fujiwara Y, Nagai R, Yoshida M, Ueda S (Feb 2008). "Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma". International Journal of Urology. 15 (2): 166–70. doi:10.1111/j.1442-2042.2007.01947.x. PMID 18269457. S2CID 205487158.
Yao XM, Wang CH, Song BL, Yang XY, Wang ZZ, Qi W, Lin ZX, Chang CC, Chang TY, Li BL (Dec 2005). "Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes". Acta Biochimica et Biophysica Sinica. 37 (12): 797–806. doi:10.1111/j.1745-7270.2005.00118.x. PMID 16331323.
Ohta T, Takata K, Katsuren K, Fukuyama S (Jun 2004). "The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (−77G→A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1682 (1–3): 56–62. doi:10.1016/j.bbalip.2004.01.008. PMID 15158756.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S (Feb 2009). "Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone". Clinica Chimica Acta; International Journal of Clinical Chemistry. 400 (1–2): 48–55. doi:10.1016/j.cca.2008.10.009. PMID 18996102.
Jiang ZY, Jiang CY, Wang L, Wang JC, Zhang SD, Einarsson C, Eriksson M, Han TQ, Parini P, Eggertsen G (Jan 2009). "Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients". Biochemical and Biophysical Research Communications. 379 (1): 49–54. doi:10.1016/j.bbrc.2008.11.131. PMID 19071091.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 염색체 6번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000120437 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000023832 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: acetyl-Coenzyme A acetyltransferase 2".

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ACAT2

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레퍼런스

외부 링크

추가 정보