호모 사피엔스 종의 단백질 코드 유전자
아나베이스 촉진 복합체 서브유닛2 는 ANAPC2 [5] [6] 효소 이다.
아나파기촉진복합체 (APC) 또는 사이클로솜이라고 불리는 대형 단백질 복합체는 유사분열성 사이클린 및 아나파기 억제제 등의 특정 기질을 유비쿼티화함으로써 메타파기-아나파기 전이를 촉진하고, 이들 기질은 26S 프로테아솜 에 의해 그 후에 분해된다.생화학적 연구는 척추동물 APC가 8개의 서브유닛을 포함하고 있다는 것을 보여준다. APC의 조성은 효모에서 인간에 이르는 유기체에서 매우 잘 보존된다. 이 유전자의 산물은 복합체의 구성 요소이며 최근에 확인된 컬린 이라고 불리는 단백질 패밀리와의 배열 유사성을 공유하며, 이것은 또한 유비퀴틴 매개 [6]
상호 작용 ANAPC2는 ANAPC1 [7] [8] [5] [9] ANAPC11 과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000176248 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026965 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex" . Mol Biol Cell . 12 (12): 3839–51. doi :10.1091/mbc.12.12.3839 . PMC 60759 PMID 11739784 . ^ a b "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2" .^ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 ISSN 0960-9822 . PMID 12956947 . S2CID 5942532 . ^ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase" . J. Cell Biol . 151 (4): 749–62. doi :10.1083/jcb.151.4.749 . ISSN 0021-9525 . PMC 2169443 PMID 11076961 . ^ Ohta, T; Michel J J; Schottelius A J; Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell . 3 (4): 535–41. doi :10.1016/S1097-2765(00)80482-7 . ISSN 1097-2765 . PMID 10230407 .
외부 링크 추가 정보 Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science . 279 (5354): 1219–22. Bibcode :1998Sci...279.1219Y . doi :10.1126/science.279.5354.1219 . PMID 9469815 . Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex" . J. Biol. Chem . 274 (20): 14500–7. doi :10.1074/jbc.274.20.14500 PMID 10318877 . Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons" . Proc. Natl. Acad. Sci. U.S.A . 96 (20): 11317–22. Bibcode :1999PNAS...9611317G . doi :10.1073/pnas.96.20.11317 PMC 18031 PMID 10500174 . Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73. doi :10.1093/dnares/7.1.65 PMID 10718198 . Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 PMC 16806 PMID 10922056 . Jarrett CR, Blancato J, Cao T, et al. (2001). "Human APC2 localization and allelic imbalance". Cancer Res . 61 (21): 7978–84. PMID 11691822 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68. doi :10.1016/S0960-9822(03)00581-5 PMID 12956947 . S2CID 5942532 . Capron A, Serralbo O, Fülöp K, et al. (2004). "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit" . Plant Cell . 15 (10): 2370–82. doi :10.1105/tpc.013847 . PMC 197302 PMID 14508008 . Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation" . EMBO J . 22 (24): 6598–609. doi :10.1093/emboj/cdg627 . PMC 291822 PMID 14657031 . Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74. Bibcode :2004Natur.429..369H . doi :10.1038/nature02465 . PMC 2734081 PMID 15164053 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Dube P, Herzog F, Gieffers C, et al. (2006). "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C" . Mol. Cell . 20 (6): 867–79. doi :10.1016/j.molcel.2005.11.008 PMID 16364912 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 .
