호모 사피엔스 종의 단백질 코드 유전자
Rho GTPase 활성화 단백질 5는 ARHGAP5 [5] [6] 유전자 에 의해 인체 내에서 코드되는 효소 이다.
기능. Rho GTPase 활성화 단백질 5는 결합된 GTP의 가수분해를 자극함으로써 세포골격 변화를 매개할 수 있는 패밀리인 RHO GTPases를 음성적으로 조절한다. 이 [6]
상호 작용 ARHGAP5는 Rnd1 ,[7] Rnd2 ,[7] Rnd3 [7] RHOA 와 [7] 나타났습니다 .
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000100852 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035133 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (1995). "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking" . J. Biol. Chem . 270 (52): 30919–26. doi :10.1074/jbc.270.52.30919 PMID 8537347 . ^ a b "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5" .^ a b c d Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP" . Curr. Biol . 13 (13): 1106–15. doi :10.1016/S0960-9822(03)00418-4 . PMC 6918695 PMID 12842009 . 외부 링크 추가 정보 Ellis C, Moran M, McCormick F, Pawson T (1990). "Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases". Nature . 343 (6256): 377–81. doi :10.1038/343377a0 . hdl :1807/9436 PMID 1689011 . Foster R, Hu KQ, Shaywitz DA, Settleman J (1994). "p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly" . Mol. Cell. Biol . 14 (11): 7173–81. doi :10.1128/mcb.14.11.7173 . PMC 359251 PMID 7935432 . McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T (1993). "The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion" . EMBO J . 12 (8): 3073–81. doi :10.1002/j.1460-2075.1993.tb05976.x . PMC 413572 PMID 8344248 . Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, Avraham S, Avraham H (2000). "RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion" . Oncogene . 19 (10): 1318–28. doi :10.1038/sj.onc.1203422 PMID 10713673 . Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T (2000). "Role of p120 Ras-GAP in directed cell movement" . J. Cell Biol . 149 (2): 457–70. doi :10.1083/jcb.149.2.457 . PMC 2175152 PMID 10769036 . Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM (2000). "P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer". Cell Growth Differ . 11 (7): 343–54. PMID 10939588 . Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, Ullrich A, Miyazaki H (2003). "Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone" . Mol. Endocrinol . 17 (4): 534–49. doi :10.1210/me.2002-0187 PMID 12554790 . Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP" . Curr. Biol . 13 (13): 1106–15. doi :10.1016/S0960-9822(03)00418-4 . PMC 6918695 PMID 12842009 . Su L, Agati JM, Parsons SJ (2003). "p190RhoGAP is cell cycle regulated and affects cytokinesis" . J. Cell Biol . 163 (3): 571–82. doi :10.1083/jcb.200308007 . PMC 2173658 PMID 14610059 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods . 35 (1): 44–53. doi :10.1016/j.ymeth.2004.07.007 . PMID 15588985 . Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM (2006). "P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland" . Mol. Endocrinol . 20 (6): 1391–405. doi :10.1210/me.2005-0426 PMID 16469769 . Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem . 354 (2): 279–89. doi :10.1016/j.ab.2006.05.024 . PMID 16777052 .
