피브리노겐 알파 체인
Fibrinogen alpha chain
피브리노겐 알파 체인은 인간에게 FGA 유전자에 의해 암호화된 단백질이다.
함수
이 유전자에 의해 암호화된 단백질은 피브리노겐의 알파 성분으로, 3쌍의 비식별성 폴리펩타이드 체인으로 구성된 혈액 매개 당단백질이다.혈관 부상에 이어 트롬빈에 의해 피브리노겐이 갈라져 피브린을 형성하는데, 이는 혈전의 가장 풍부한 성분이다.또한 피브리노겐과 피브린의 다양한 갈라진 산물은 세포 유착과 확산을 조절하고, 혈관확장기와 화학작용을 표시하며, 여러 종류의 세포에 대한 미토균이다.이 유전자의 돌연변이는 이피브린겐혈증, 저피브린겐혈증, 아피브린겐혈증, 신장 아밀로이드증 등 여러 질환으로 이어진다.대체 스플라이싱은 카복시-터미너스에서 다양한 두 개의 이소 형태를 만든다.[5]
상호작용
피브리노겐 알파 체인은 조직 플라시노겐 활성제와 상호작용하는 것으로 나타났다.[6][7]
참고 항목
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000171560 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000028001 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: FGA fibrinogen alpha chain".
- ^ Tsurupa G, Medved L (Jan 2001). "Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains". Biochemistry. 40 (3): 801–808. doi:10.1021/bi001789t. PMID 11170397.
- ^ Ichinose A, Takio K, Fujikawa K (Jul 1986). "Localization of the binding site of tissue-type plasminogen activator to fibrin". The Journal of Clinical Investigation. 78 (1): 163–169. doi:10.1172/JCI112546. PMC 329545. PMID 3088041.
추가 읽기
- Doolittle RF (1984). "Fibrinogen and fibrin". Annual Review of Biochemistry. 53: 195–229. doi:10.1146/annurev.bi.53.070184.001211. PMID 6383194.
- Galanakis DK (1994). "Inherited dysfibrinogenemia: emerging abnormal structure associations with pathologic and nonpathologic dysfunctions". Seminars in Thrombosis and Hemostasis. 19 (4): 386–395. doi:10.1055/s-2007-993290. PMID 8140431.
- Herrick S, Blanc-Brude O, Gray A, Laurent G (Jul 1999). "Fibrinogen". The International Journal of Biochemistry & Cell Biology. 31 (7): 741–746. doi:10.1016/S1357-2725(99)00032-1. PMID 10467729.
- Bennett JS (2001). "Platelet-fibrinogen interactions". Annals of the New York Academy of Sciences. 936: 340–354. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491. S2CID 25431334.
- Redman CM, Xia H (2001). "Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion". Annals of the New York Academy of Sciences. 936: 480–495. doi:10.1111/j.1749-6632.2001.tb03535.x. PMID 11460506. S2CID 31741202.
- Matsuda M, Sugo T (Aug 2002). "Structure and function of human fibrinogen inferred from dysfibrinogens". International Journal of Hematology. 76 Suppl 1: 352–60. doi:10.1007/bf03165284. PMID 12430881. S2CID 11165476.
{{cite journal}}:날짜 값 확인:year=/date=불일치(도움말) - Everse SJ (Aug 2002). "New insights into fibrin (ogen) structure and function". Vox Sanguinis. 83 Suppl 1: 375–82. doi:10.1111/j.1423-0410.2002.tb05338.x. PMID 12617173. S2CID 21813767.
{{cite journal}}:날짜 값 확인:year=/date=불일치(도움말) - Scott EM, Ariëns RA, Grant PJ (Sep 2004). "Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease". Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (9): 1558–1566. doi:10.1161/01.ATV.0000136649.83297.bf. PMID 15217804.
{{cite journal}}:날짜 값 확인:year=/date=불일치(도움말) - Lord ST (May 2007). "Fibrinogen and fibrin: scaffold proteins in hemostasis". Current Opinion in Hematology. 14 (3): 236–241. doi:10.1097/MOH.0b013e3280dce58c. PMID 17414213. S2CID 31315177.
- Cottrell BA, Strong DD, Watt KW, Doolittle RF (Nov 1979). "Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites". Biochemistry. 18 (24): 5405–5410. doi:10.1021/bi00591a023. PMID 518845.
{{cite journal}}:날짜 값 확인:year=/date=불일치(도움말) - Watt KW, Cottrell BA, Strong DD, Doolittle RF (Nov 1979). "Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence". Biochemistry. 18 (24): 5410–5416. doi:10.1021/bi00591a024. PMID 518846.
{{cite journal}}:날짜 값 확인:year=/date=불일치(도움말) - Fretto LJ, Ferguson EW, Steinman HM, McKee PA (Apr 1978). "Localization of the alpha-chain cross-link acceptor sites of human fibrin". The Journal of Biological Chemistry. 253 (7): 2184–95. PMID 632262.
- Blombäck B, Hessel B, Hogg D (May 1976). "Disulfide bridges in nh2 -terminal part of human fibrinogen". Thrombosis Research. 8 (5): 639–658. doi:10.1016/0049-3848(76)90245-0. PMID 936108.
- Koopman J, Haverkate F, Grimbergen J, Egbring R, Lord ST (Oct 1992). "Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA)". Blood. 80 (8): 1972–9. doi:10.1182/blood.V80.8.1972.1972. PMID 1391954.
- Fu Y, Weissbach L, Plant PW, Oddoux C, Cao Y, Liang TJ, Roy SN, Redman CM, Grieninger G (Dec 1992). "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits". Biochemistry. 31 (48): 11968–11972. doi:10.1021/bi00163a002. PMID 1457396.
{{cite journal}}:날짜 값 확인:year=/date=불일치(도움말) - Martin PD, Robertson W, Turk D, Huber R, Bode W, Edwards BF (Apr 1992). "The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution". The Journal of Biological Chemistry. 267 (11): 7911–20. PMID 1560020.
- Stubbs MT, Oschkinat H, Mayr I, Huber R, Angliker H, Stone SR, Bode W (May 1992). "The interaction of thrombin with fibrinogen. A structural basis for its specificity". European Journal of Biochemistry. 206 (1): 187–195. doi:10.1111/j.1432-1033.1992.tb16916.x. PMID 1587268.
- Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, Arocha-Piñango CL, Rodriguez S, Nagy H, Perez-Requejo JL (Jul 1992). "Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator". The Journal of Clinical Investigation. 90 (1): 67–76. doi:10.1172/JCI115857. PMC 443064. PMID 1634621.
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