호모 사피엔스 종의 단백질 코드 유전자
HCFC1 식별자 에일리어스 HCFC1 외부 ID OMIM : 300019 MGI: 105942 HomoloGene : 3898 GeneCard: HCFC1 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr X: 153.95 ~153.97 Mb Chr X: 72.99 ~73.01 Mb PubMed 검색[3] [4] 위키데이터
VP16-액세서리 [5] 숙주 세포 인자 1(HCFC1 , HCF1 , 또는 HCF-1 )은 인체 에서 HCFC1 [6] [7] 단백질 이다.
구조. HCF1은 고도로 보존된 숙주세포인자 패밀리의 일원으로, 5개의 켈치 반복, 피브로넥틴 유사 모티브 및 6개의 HCF 반복으로 단백질을 부호화하며, 각각은 매우 특이적인 절단 신호를 포함한다. 이 핵전사 코어조절기 는 가능한 6개 부위 중 하나 이상에서 단백질 분해되어 N-말단 사슬과 대응 하는 C-말단 사슬을 생성한다. 이 단백질의 최종 형태는 정전력을 통해 상호작용하는 비공유 결합 N- 및 C-말단 체인으로 구성됩니다.
기능. HCF1은 세포주기 의 제어와 전사와 관련 된 다수의 프로세스에서 조절역할을 하는 데 관여한다. 또한 모델 유기체에서의 연구는 추정 수명 결정 요인으로서 HCF1을 [8] 다른 단백질 아이소폼을 코드하는 대체 스플라이스 변형이 설명되었지만, 모든 변종이 완전히 [7]
이 유전자의 돌연변이는 코발라민 [9]
상호 작용 호스트 셀 팩터 C1은 다음과 상호작용하는 것 으로 나타났습니다.
BAP1 ,[10] CREB3 ,[11] [12] 갑파 ,[13] HDAC1 ,[14] HDAC2 ,[14] MLL ,[15] OGT ,[14] PDCD2 ,[16] POU2F1 ,[17] [18] PPP1CA ,[19] SIN3A ,[14] [15] SP1 ,[14] [20] SUDS3 ,[14] WDR5 ,[14] [15] ZBTB17 .[21] 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000172534 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000031386 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ HCFC1 , http:// genecards .org용 GeneCard 엔트리 2013-10-14 Wayback Machine 아카이브 완료^ Wilson AC, LaMarco K, Peterson MG, Herr W (Jul 1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell . 74 (1): 115–25. doi :10.1016/0092-8674(93)90299-6 . PMID 8392914 . S2CID 43569318 . ^ a b "Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)" .^ Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS (Sep 2008). "Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator" . PLOS Biology . 6 (9): e233. doi :10.1371/journal.pbio.0060233 . PMC 2553839 PMID 18828672 . ^ Yu HC, Sloan JL, Scharer G, Brebner A, Quintana AM, Achilly NP, Manoli I, Coughlin CR, Geiger EA, Schneck U, Watkins D, Suormala T, Van Hove JL, Fowler B, Baumgartner MR, Rosenblatt DS, Venditti CP, Shaikh TH (Sep 2013). "An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1" . American Journal of Human Genetics . 93 (3): 506–14. doi :10.1016/j.ajhg.2013.07.022 . PMC 3769968 PMID 24011988 . ^ Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A (Dec 2009). "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1" . The Journal of Biological Chemistry . 284 (49): 34179–88. doi :10.1074/jbc.M109.046755 PMC 2797188 PMID 19815555 . ^ Lu R, Yang P, Padmakumar S, Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF" . Journal of Virology . 72 (8): 6291–7. doi :10.1128/JVI.72.8.6291-6297.1998 . PMC 109766 PMID 9658067 . ^ Freiman RN, Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP" . Genes & Development . 11 (23): 3122–7. doi :10.1101/gad.11.23.3122 . PMC 316754 PMID 9389645 . ^ Vogel JL, Kristie TM (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP" . The EMBO Journal . 19 (4): 683–90. doi :10.1093/emboj/19.4.683 . PMC 305606 PMID 10675337 . ^ a b c d e f g Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1" . Genes & Development . 17 (7): 896–911. doi :10.1101/gad.252103 . PMC 196026 PMID 12670868 . ^ a b c Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression" . Molecular and Cellular Biology . 24 (13): 5639–49. doi :10.1128/MCB.24.13.5639-5649.2004 . PMC 480881 PMID 15199122 . ^ Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)" . Oncogene . 21 (34): 5245–54. doi :10.1038/sj.onc.1205647 PMID 12149646 . ^ La Boissière S, Hughes T, O'Hare P (Jan 1999). "HCF-dependent nuclear import of VP16" . The EMBO Journal . 18 (2): 480–9. doi :10.1093/emboj/18.2.480 . PMC 1171141 PMID 9889203 . ^ Kristie TM, Sharp PA (Mar 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)" . The Journal of Biological Chemistry . 268 (9): 6525–34. doi :10.1016/S0021-9258(18)53282-8 PMID 8454622 . ^ Ajuh PM, Browne GJ, Hawkes NA, Cohen PT, Roberts SG, Lamond AI (Feb 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex" . Nucleic Acids Research . 28 (3): 678–86. doi :10.1093/nar/28.3.678 . PMC 102561 PMID 10637318 . ^ Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry . 210 (1–2): 131–42. doi :10.1023/A:1007177623283 . PMID 10976766 . S2CID 1339642 . ^ Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1" . The Journal of Biological Chemistry . 277 (48): 46799–808. doi :10.1074/jbc.M206226200 PMID 12244100 .
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