호모 사피엔스 종의 단백질 코드 유전자
호메오도메인 상호작용단백질인산화효소1 은 HIPK1 유전자에 [5] 효소 이다.
기능. 이 유전자에 의해 코드된 단백질은 Ser/Thr 계열의 단백질 키나아제 및 HIPK 서브패밀리에 속합니다. 호메오도메인 전사인자를 인산화하며 호메오도메인 전사인자의 공동억제제로서 기능할 수도 있다. 대체 스플라이싱은 4개의 서로 다른 Isoform을 [5]
상호 작용 HIPK1은 P53 과 [6] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000163349 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000008730 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1" .^ Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (9): 5431–6. Bibcode :2003PNAS..100.5431K . doi :10.1073/pnas.0530308100 PMC 154362 PMID 12702766 . 추가 정보 Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 PMID 9734811 . Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Oct 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors" . The Journal of Biological Chemistry . 273 (40): 25875–9. doi :10.1074/jbc.273.40.25875 PMID 9748262 . Ecsedy JA, Michaelson JS, Leder P (Feb 2003). "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity" . Molecular and Cellular Biology . 23 (3): 950–60. doi :10.1128/MCB.23.3.950-960.2003 . PMC 140690 PMID 12529400 . Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (9): 5431–6. Bibcode :2003PNAS..100.5431K . doi :10.1073/pnas.0530308100 PMC 154362 PMID 12702766 . Song JJ, Lee YJ (Nov 2003). "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization" . The Journal of Biological Chemistry . 278 (47): 47245–52. doi :10.1074/jbc.M213201200 PMID 12968034 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W (Apr 2005). "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation" . The Journal of Biological Chemistry . 280 (15): 15061–70. doi :10.1074/jbc.M414262200 PMID 15701637 . 
