KIR3DL3
KIR3DL3
킬러 세포 면역글로불린 유사 수용체 3DL3는 인간 내 KIR3DL3 유전자에 의해 암호화된 단백질이다.[5][6]
킬러 세포 면역글로불린 유사 수용체(KIRs)는 자연 킬러 세포와 T 세포의 서브셋에 의해 발현되는 트랜섬브레인 당단백질이다.KIR 유전자는 다형성 및 고동맥성으로 1Mb 백혈구 수용체 복합체(LRC) 내 염색체 19q13.4의 성단에서 발견된다.여러 "프레임워크" 유전자가 모든 하플라타입(KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2)에서 발견되지만 KIR 유전자 군집의 유전자 함량은 하플라타입에 따라 다르다.KIR 단백질은 세포외 면역글로불린 영역 수(2D 또는 3D)와 세포질 영역이 긴지 짧은지(S)로 분류된다.면역 티로신 기반 억제 모티브(ITIM)를 통해 리간드 결합 시 긴 세포질 영역 변환 억제 신호를 가진 KIR 단백질은 ITIM 모티브가 부족한 반면, 짧은 세포질 영역을 가진 KIR 단백질은 대신 TYRO 단백질 티로신 키나제 결합 단백질과 결합하여 변환 활성 신호를 만든다.몇몇 KIR 단백질의 리간드는 HLA 등급 I 분자의 하위 집합이므로, KIR 단백질은 면역 반응의 조절에 중요한 역할을 한다고 생각된다.이 유전자는 모든 happlotype에 존재하는 "framework" loci의 하나이다.[6]
참조
- ^ a b c ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 GRCh38: Ensembl release 89: ENSG00000274394, ENSG00000283823, ENSG00000274511, ENSG00000276196, ENSG00000275433, ENSG00000276086, ENSG00000283875, ENSG00000274480, ENSG00000277392, ENSG00000274786, ENSG00000274724, ENSG00000276930, ENSG00000276572, ENSG00000284371, ENSG00000276084, ENSG00000284104, ENSG00000278729, ENSG00000277028, ENSG00000275062, ENSG00000274763, ENSG00000276433, ENSG00000274639, ENSG00000283966, ENSG00000284127, ENSG00000277552, ENSG00000278490, ENSG00000276806, ENSG00000242019, ENSG00000276328, ENSG00000276875, ENSG00000274556, ENSG00000283915, ENSG00000284086, ENSG00000278723, ENSG00000284480, ENSG00000273502, ENSG00000274254, ENSG00000275172, ENSG00000275513, ENSG00000277620, ENSG00000274696, ENSG00000277596 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000057439 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, Rajagopalan S, Renard V, Sandusky M, Stebbins CC, Wagtmann N, Watzl C (Aug 2001). "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev. 181: 223–233. doi:10.1034/j.1600-065X.2001.1810119.x. PMID 11513144. S2CID 13312691.
- ^ a b "Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3".
추가 읽기
- Dou LP, Zheng DH, Wang C, et al. (2008). "The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people". Int. J. Hematol. 87 (4): 422–433. doi:10.1007/s12185-008-0058-7. PMID 18347914. S2CID 32702080.
- Pavlova Y, Kolesar L, Striz I, et al. (2008). "Distribution of KIR genes in the Czech population". International Journal of Immunogenetics. 35 (1): 57–61. doi:10.1111/j.1744-313X.2007.00737.x. PMID 18186800. S2CID 25268211.
- Zhi-ming L, Yu-lian J, Zhao-lei F, et al. (2008). "Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population". Croat. Med. J. 48 (6): 800–807. doi:10.3325/cmj.2007.6.800. PMC 2213808. PMID 18074414.
- Middleton D, Meenagh A, Sleator C, et al. (2007). "No association of KIR genes with Behcet's disease". Tissue Antigens. 70 (5): 435–438. doi:10.1111/j.1399-0039.2007.00929.x. PMID 17868255.
- Flores AC, Marcos CY, Paladino N, et al. (2007). "KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations". Tissue Antigens. 69 (6): 568–576. doi:10.1111/j.1399-0039.2007.00824.x. PMID 17498266.
- Chen AM, Guo XM, Yan WY, et al. (2007). "[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15 (1): 35–8. PMID 17490516.
- Jones DC, Hiby SE, Moffett A, et al. (2006). "Nature of allelic sequence polymorphism at the KIR3DL3 locus". Immunogenetics. 58 (8): 614–627. doi:10.1007/s00251-006-0130-5. PMID 16823588. S2CID 6120931.
- Steiner NK, Hurley CK (2006). "KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions". Tissue Antigens. 67 (4): 277–283. doi:10.1111/j.1399-0039.2006.00567.x. PMID 16634863.
- Zhu FM, Jiang K, Lü QF, et al. (2005). "[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13 (6): 1109–12. PMID 16403292.
- Trundley AE, Hiby SE, Chang C, et al. (2006). "Molecular characterization of KIR3DL3". Immunogenetics. 57 (12): 904–916. doi:10.1007/s00251-005-0060-7. PMID 16391939. S2CID 25125407.
- Jiang K, Zhu FM, Lv QF, Yan LX (2005). "Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population". Tissue Antigens. 65 (6): 556–563. doi:10.1111/j.1399-0039.2005.00412.x. PMID 15896204.
- Trompeter HI, Gómez-Lozano N, Santourlidis S, et al. (2005). "Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3". J. Immunol. 174 (7): 4135–43. doi:10.4049/jimmunol.174.7.4135. PMID 15778373.
- Arnheim L, Dillner J, Sanjeevi CB (2005). "A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia". Tissue Antigens. 65 (3): 252–259. doi:10.1111/j.1399-0039.2005.00359.x. PMID 15730517.
- Norman PJ, Carrington CV, Byng M, et al. (2002). "Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations". Genes Immun. 3 (2): 86–95. doi:10.1038/sj.gene.6363836. PMID 11960306.
- Torkar M, Norgate Z, Colonna M, et al. (1999). "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex". Eur. J. Immunol. 28 (12): 3959–3967. doi:10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2. PMID 9862332.
