RGS8

RGS8
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2IHD, 2ODE, 5DO9
식별자
에일리어스	RGS8, G단백질신호조절제8
외부 ID	OMIM : 607189 MGI : 108408 HomoloGene : 23152 GenCard : RGS8
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	182,684,587 bp
유전자 위치(마우스)
크르.	1번 염색체(마우스)
끝.	153,576,069 bp
RNA발현패턴
	상단 표시 위치:
	핵액컴벤스; ; 핀; ; 창호; ; 미산핵; ; 소뇌충; ; 정자; ; 시상하부; ; 전전두피질; ; 외이성 망막; ; 브로드만 영역 46;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	GO:0001948, GO:0016582 단백질 결합; GO:0005097, GO:0005099, GO:0005100 GTPase 액티베이터 액티베이션; GO:0006184 GTPase 액티비티;
셀룰러 컴포넌트	세포질; 혈장막 세포질 측 외인성 성분; 신경세포체막; 근점; 혈장막; 수상돌기; 세포 투영; 막; 핵;
생물학적 과정	G단백질결합아세틸콜린수용체신호경로; 도파민수용체신호경로조절; GO:0032320, GO:00321, GO:0032855, GO:0043089, GO:0032854 GTPase 액티비티의 플러스 레귤레이션; 신호 전달의 음성 조절; G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	85397
	67792
	ENSG00000135824
	ENSMUSG000042671
	P57771
	Q8BXT1
NM_001102450; NM_033345; NM_001369564; NM_001387847; NM_001387848;
	NM_001387849
	NM_026380; NM_001347115; NM_001357525
	NP_001095920; NP_203131; NP_001356493
	NP_001334044; NP_080656; NP_001344454
	위키데이터
인간 보기/편집	마우스 표시/편집

G단백질 시그널링 8의 조절제는 RGS8 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 단백질이다.

이 유전자는 G단백질 시그널링(RGS) 패밀리의 조절기 멤버로 단일 RGS 도메인으로 단백질을 암호화한다.G단백질신호(RGS)단백질조절제는 G단백질결합수용체복합체의 조절 및 구조성분이다.GTP 결합 및 GDP에 대한 가수분해 사이클을 통해 전달을 가속화하여 신호 전달을 종료하지만, 역설적으로 수용체 자극 ^[6]활성화도 가속화한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000135824 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000042671 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
^ ^a ^b "Entrez Gene: RGS8 regulator of G-protein signalling 8".

추가 정보

Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell. 7 (3): 651–660. doi:10.1016/S1097-2765(01)00211-8. PMID 11463389.
Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". J Biol Chem. 286 (17): 15116–15125. doi:10.1074/jbc.M110.216234. PMC 3083217. PMID 21357625.
Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J Biol Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990.
Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476.
Saitoh O, Murata Y, Odagiri M, et al. (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. Bibcode:2002PNAS...9910138S. doi:10.1073/pnas.152085999. PMC 126637. PMID 12110731.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression". J. Neurochem. 88 (1): 161–8. doi:10.1046/j.1471-4159.2003.02139.x. PMID 14675160.
Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
Saitoh O, Yoshihiro K (2005). "Biochemical and electrophysiological analyses of RGS8 function". Meth. Enzymol. Methods in Enzymology. 390: 129–48. doi:10.1016/S0076-6879(04)90009-2. ISBN 9780121827953. PMID 15488175.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Benians A, Nobles M, Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. doi:10.1042/BST0321045. PMID 15506959.
Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics". J. Biol. Chem. 280 (14): 13383–94. doi:10.1074/jbc.M410163200. PMID 15677457.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM (2010). "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms. 3 (9–10): 567–580. doi:10.1242/dmm.003210. PMC 2931535. PMID 20616094.
Wilkie TM, Kinch L (2005). "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology. 15 (20): R843-54. doi:10.1016/j.cub.2005.10.008. PMID 16243026. S2CID 18174795.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000135824 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000042671 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11318611-5] Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.

[entrez-6] "Entrez Gene: RGS8 regulator of G-protein signalling 8".

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RGS8

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