E3 유비퀴틴-단백질 연결효소 RNF216 은 RNF216 [5] 효소 이다.
이 유전자는 세린/트레오닌 단백질 키나아제, 수용체 상호작용 단백질(RIP)에 특이적으로 콜로컬화 및 상호작용하는 세포질 단백질을 암호화한다. 부호화 단백질의 아연 핑거 도메인은 RIP와의 상호작용 및 TNF 및 IL1 유도 NF-카파 B 활성화 경로의 저지에 필요하다. 코드화된 단백질은 또한 E2 유비퀴틴 결합 효소로부터 유비퀴틴을 받아들여 기질에 전달하는 E3 유비퀴틴 단백질 연결 효소로 기능할 수 있다. 이 궤적에 대해 몇 가지 대체적으로 스플라이스된 전사 변형이 설명되었지만 일부의 전체 길이 특성만 [5]
「 」를 참조해 주세요. 상호 작용 RNF216은 TLR9 [6] RIPK1 과 [7] 것 으로 나타났습니다.
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