TBC1 도메인 패밀리 멤버 3E /3F는 TBC1D3F [3] [4] 유전자에 의해 인체 내에서 암호화되는 단백질 이다.
이 유전자는 TBC1 도메인 패밀리, 멤버 3과 유사한 단백질을 암호화합니다. 이 단백질은 RAB GTPase 시그널링 및 소포트래픽 에 관여하는 단백질에서 발견되는 TBC(Tre-2, Bub2p, Cdc16p) 도메인을 포함 한다. 이 유전자의 두 개 의 복사본 이 17q 염색체의 케모카인 유전자 군집 내에 위치해 있다; 이 기록은 더 중심적 인 [4] 복제를 나타낸다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000275954 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD (Nov 2006). "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12" . Genomics . 88 (6): 731–6. doi :10.1016/j.ygeno.2006.05.009 . PMID 16863688 . ^ a b "Entrez Gene: TBC1D3 TBC1 domain family, member 3" . 추가 정보 Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene . 131 (2): 209–15. doi :10.1016/0378-1119(93)90295-E . PMID 8406013 . Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol . 12 (2): 107–18. doi :10.1089/dna.1993.12.107 . PMID 8471161 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 . PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 . PMID 11230166 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene" . Proc. Natl. Acad. Sci. U.S.A . 100 (5): 2507–11. Bibcode :2003PNAS..100.2507P . doi :10.1073/pnas.0437015100 . PMC 151371 . PMID 12604796 . Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling" . Mol. Cell. Biol . 23 (6): 2151–61. doi :10.1128/MCB.23.6.2151-2161.2003 . PMC 149457 . PMID 12612085 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 . PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 . PMID 16381901 .