TXNIP

TXNIP
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	4GEI, 4GEJ, 4GFX, 4LL1, 4LL4, 4ROF, 4ROJ, 5CQ2, 5DF6, 5DWS, 5DZD
식별자
별칭	TXNIP, 티오레독신 상호작용 단백질, EST01027, HHCPA78, THIF, VDUP1, ARDC6
외부 ID	OMIM: 606599 MGI: 1889549 호몰로진: 38186 GeneCard: TXNIP
유전자 위치(인간)
쳇.	염색체 1 (인간)
끝	145,996,579 bp
유전자 위치(마우스)
쳇.	3번 염색체(쥐)
끝	96,469,199 bp
RNA 표현 패턴
	표현된 상단
	체쿰; ; 비뇨기 방광; ; 식도; ; 오른쪽 폐; ; 핏덩어리; ; 위 점막;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0048551 효소 억제제 활성; GO:0001948 단백질 결합; 유비퀴틴 단백질 리가제 결합;
셀룰러 컴포넌트	세포질; 시토솔; 미토콘드리아 간 공간; 핵의;
생물학적 과정	종양 세포에 대한 세포 반응; 에스트라디올에 대한 반응; GO:0048553 촉매 활성의 음극 조절; 전사 규정, DNA-템플링; 핵으로 단백질을 수입하다; 프로게스테론 대응; 기계적 자극에 대한 반응; RNA 중합효소 II에 의한 전사의 음성 조절; 포도당에 대한 반응; 산화 스트레스에 대한 반응; 전사, DNA-템플릿; 각질 세포 분화; 칼슘 이온에 대한 반응; 세포분열에 대한 부정적 규제; 세포 인구증식 규제; 양세포 과정에 대한 양성 규제; 세포 순환; 혈소판 유도 성장 인자 수용체 신호 경로; 과산화수소에 대한 반응; 신호 전달;
	출처:아미고 / 퀵고
직교체
	10628
	56338
	ENSG00000265972
	ENSMUSG00000038393
	Q9H3M7
	Q8BG60
	NM_006472; NM_0013972
	NM_001009935; NM_023719
	NP_001300901; NP_006463
	NP_001009935; NP_076208
	위키다타
인간 보기/편집	마우스 보기/편집

티오레독신 상호작용 단백질은 인간에게 TXNIP 유전자에 의해 암호화된 단백질이다.^[5]^[6]

상호작용

TXNIP는 Thioredoxin^[7] 및 ZBTB32와 상호작용하는 것으로 나타났다.^[8]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000265972 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000038393 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
^ "Entrez Gene: TXNIP thioredoxin interacting protein".
^ Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
^ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

추가 읽기

Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
Ludwig DL, Kotanides H, Le T, Chavkin D, Bohlen P, Witte L (May 2001). "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene". Gene. 269 (1–2): 103–12. doi:10.1016/S0378-1119(01)00455-3. PMID 11376942.
Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ (Jan 2002). "Positional cloning of the combined hyperlipidemia gene Hyplip1". Nature Genetics. 30 (1): 110–6. doi:10.1038/ng811. PMC 2846781. PMID 11753387.
Joguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D (Apr 2002). "Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat". Biochemical and Biophysical Research Communications. 293 (1): 293–7. doi:10.1016/S0006-291X(02)00208-5. PMID 12054598.
Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM (Sep 2002). "The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin". Proceedings of the National Academy of Sciences of the United States of America. 99 (18): 11700–5. Bibcode:2002PNAS...9911700B. doi:10.1073/pnas.182372299. PMC 129332. PMID 12189205.
Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT (Oct 2002). "Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin". Circulation Research. 91 (8): 689–95. doi:10.1161/01.RES.0000037982.55074.F6. PMID 12386145.
Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.
Champliaud MF, Viel A, Baden HP (Oct 2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". The Journal of Investigative Dermatology. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
Kim KY, Shin SM, Kim JK, Paik SG, Yang Y, Choi I (Mar 2004). "Heat shock factor regulates VDUP1 gene expression". Biochemical and Biophysical Research Communications. 315 (2): 369–75. doi:10.1016/j.bbrc.2004.01.047. PMID 14766217.
Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT (Jul 2004). "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein". The Journal of Biological Chemistry. 279 (29): 30369–74. doi:10.1074/jbc.M400549200. PMID 15128745.
Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, Weiss R, Hunt SC, Leppert MF (Jun 2004). "TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study". Atherosclerosis. 174 (2): 357–62. doi:10.1016/j.atherosclerosis.2004.02.004. PMID 15136067.
Nishinaka Y, Masutani H, Oka S, Matsuo Y, Yamaguchi Y, Nishio K, Ishii Y, Yodoi J (Sep 2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1". The Journal of Biological Chemistry. 279 (36): 37559–65. doi:10.1074/jbc.M405473200. PMID 15234975.
Aitken CJ, Hodge JM, Nishinaka Y, Vaughan T, Yodoi J, Day CJ, Morrison NA, Nicholson GC (Dec 2004). "Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling". Journal of Bone and Mineral Research. 19 (12): 2057–64. doi:10.1359/JBMR.040913. PMID 15537450. S2CID 26600161.
Yamawaki H, Pan S, Lee RT, Berk BC (Mar 2005). "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells". The Journal of Clinical Investigation. 115 (3): 733–8. doi:10.1172/JCI23001. PMC 546457. PMID 15696199.
Minn AH, Hafele C, Shalev A (May 2005). "Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis". Endocrinology. 146 (5): 2397–405. doi:10.1210/en.2004-1378. PMID 15705778.

인간 염색체 1번 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000265972 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000038393 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8086474-5] Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.

[entrez-6] "Entrez Gene: TXNIP thioredoxin interacting protein".

[pmid10419473-7] Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.

[pmid12821938-8] Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

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TXNIP

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목차

상호작용

관련 유전자 문제

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