CEP164 라고도 알려진 164 kDa의 센트로소마 단백질 은 인간에서 CEP164 유전자 에 의해 인코딩되는 단백질 이다.[5] [6] 그것의 기능은 두 가지로 나타난다: CEP164는 일차 질륨 형성을 위해 필요하다.[7] 게다가, 그것은 UV 빛에 의한 DNA 손상에 대한 반응에 있어 중요한 요소다.[8] [9]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000110274 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000043987 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: centrosomal protein 164kDa" .^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature . 426 (6966): 570–4. doi :10.1038/nature02166 . PMID 14654843 . S2CID 4427303 . ^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation" . The Journal of Cell Biology . 179 (2): 321–30. doi :10.1083/jcb.200707181 . PMC 2064767 PMID 17954613 . ^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1" . Genes & Development . 22 (5): 587–600. doi :10.1101/gad.1627708 . PMC 2259029 PMID 18283122 . ^ Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity" . Cell Cycle . 8 (4): 655–64. doi :10.4161/cc.8.4.7844 PMID 19197159 . 외부 링크 추가 읽기 Graser S, Stierhof YD, Lavoie SB, et al. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation" . J. Cell Biol . 179 (2): 321–30. doi :10.1083/jcb.200707181 . PMC 2064767 PMID 17954613 . Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function" . J. Cell Biol . 129 (6): 1617–28. doi :10.1083/jcb.129.6.1617 . PMC 2291169 PMID 7790358 . Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation" . Dev. Cell . 5 (1): 113–25. doi :10.1016/S1534-5807(03)00193-X PMID 12852856 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion" . J. Cell Biol . 151 (4): 837–46. doi :10.1083/jcb.151.4.837 . PMC 2169446 PMID 11076968 . Sivasubramaniam S, Sun X, Pan YR, et al. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1" . Genes Dev . 22 (5): 587–600. doi :10.1101/gad.1627708 . PMC 2259029 PMID 18283122 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation" . EMBO Rep . 7 (4): 418–24. doi :10.1038/sj.embor.7400639 . PMC 1456919 PMID 16462731 . Zick A, Onn I, Bezalel R, et al. (2005). "Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements" . Nucleic Acids Res . 33 (13): 4235–42. doi :10.1093/nar/gki742 . PMC 1181863 PMID 16052032 . Pan YR, Lee EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity" . Cell Cycle . 8 (4): 655–64. doi :10.4161/cc.8.4.7844 PMID 19197159 . Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex" . Mol. Biol. Cell . 13 (9): 3235–45. doi :10.1091/mbc.E02-02-0112 . PMC 124155 PMID 12221128 .
