걸쇠 1
CLASP1
CLASP1이라고도 알려진 세포질 링커 관련 단백질 1은 인간에서 CLASP1 [5]유전자에 의해 암호화되는 단백질이다.
기능.
CLASB1은 동식물의[6] [7]세포피질에 미소관을 부착하는 데 관여하는 미소관 관련 단백질군에 속한다.CLASP1과 같은 CLASP는 CLIP(예: CLIP1)와 상호 작용합니다.동물세포에서 CLASP1은 운동공 및 [5][8]방추 전체의 미소관 역학 조절에 관여한다.CLASB1은 유사분열 시 별 미세관과 세포 피질의 상호작용을 제어하며,[9] 이는 스핀들의 적절한 위치 및 방향에 중요합니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000074054 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000064302 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1".
- ^ Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
- ^ Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Molecular Biology of the Cell. 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC 2575154. PMID 18716054.
- ^ Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (June 2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247.
- ^ Samora, Catarina P.; Mogessie, Binyam; Conway, Leslie; Ross, Jennifer L.; Straube, Anne; McAinsh, Andrew D. (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. S2CID 8869880.
외부 링크
- UCSC Genome Browser의 Human CLASB1 게놈 위치 및 CLASB1 유전자 상세 페이지.
- UCSC Genome Browser의 인간 MAST1 게놈 위치 및 MAST1 유전자 상세 페이지.
추가 정보
- Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Mol Biol Cell. 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC 2575154. PMID 18716054.
- Galjart N (2005). "CLIPs and CLASPs and cellular dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712. S2CID 23216754.
- Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
- Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247.
- Maiato H, Rieder CL, Earnshaw WC, Sunkel CE (2004). "How do kinetochores CLASP dynamic microtubules?". Cell Cycle. 2 (6): 511–4. doi:10.4161/cc.2.6.576. PMID 14504462.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
- Aonuma M, Miyamoto M, Inoue YH, et al. (2006). "Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment". Cell Struct. Funct. 30 (1): 7–13. doi:10.1247/csf.30.7. PMID 16145243.
- Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
- Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment". Genes Cells. 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869. S2CID 33744175.
- Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 Cooperate to Ensure Mitotic Fidelity by Regulating Spindle and Kinetochore Function". Mol. Biol. Cell. 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
