사람에게서 발견되는 단백질
이 기사는 유전자와 암호화된 단백질에 관한 것이다. 개발도상국의 질병 관리 우선 순위 보고서(2판)는 질병 관리 우선 순위 프로젝트 를 참조하십시오. mRNA 해독 효소 2는 인간 에게 DCP2 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
DCP2는 5-프라임 엔드에서의 성능 저하에 앞서 mRNA에서 5-프라임 캡을 제거하는 데 필요한 mRNA 결정 단지의 핵심 구성요소다(Fenger-Gron et al., 2005). [OMIM에 의해 제공][7]
상호작용 DCP2는 DCP1A [8] UPF1 과 상호작용 하는 것으로 나타났다.[6] [9]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000172795 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000024472 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (October 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme" . Proceedings of the National Academy of Sciences of the United States of America . 99 (20): 12663–12668. Bibcode :2002PNAS...9912663W . doi :10.1073/pnas.192445599 PMC 130517 PMID 12218187 . ^ a b Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)" .^ Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . ^ Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities" . Molecular Cell . 12 (3): 675–687. doi :10.1016/S1097-2765(03)00349-6 PMID 14527413 .
추가 읽기 Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S (January 1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer". Human Genetics . 102 (1): 63–68. doi :10.1007/s004390050655 . PMID 9490301 . S2CID 36201527 . van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B (December 2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures" . The EMBO Journal . 21 (24): 6915–6924. doi :10.1093/emboj/cdf678 . PMC 139098 PMID 12486012 . Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–1501. doi :10.1017/S1355838202021726 (inactive 31 October 2021). PMC 1370355 PMID 12515382 . {{cite journal }}: CS1 maint : 2021년 10월 현재 DOI 비활성화(링크 ) Grzymski EC (June 2003). "Visualizing an mRNA destruction line". Nature Structural Biology . 10 (6): 416. doi :10.1038/nsb0603-416 . PMID 12768200 . S2CID 40900780 . Piccirillo C, Khanna R, Kiledjian M (September 2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2" . RNA . 9 (9): 1138–1147. doi :10.1261/rna.5690503 . PMC 1370477 PMID 12923261 . Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities" . Molecular Cell . 12 (3): 675–687. doi :10.1016/S1097-2765(03)00349-6 PMID 14527413 . Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells" . The Journal of Cell Biology . 165 (1): 31–40. doi :10.1083/jcb.200309008 . PMC 2172085 PMID 15067023 . Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–1323. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M (September 2004). "Functional analysis of mRNA scavenger decapping enzymes" . RNA . 10 (9): 1412–1422. doi :10.1261/rna.7660804 . PMC 1370627 PMID 15273322 . Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (July 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies" . Nature Cell Biology . 7 (7): 719–723. doi :10.1038/ncb1274 . PMC 1855297 PMID 15937477 . Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (December 2005). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping" . Molecular Cell . 20 (6): 905–915. doi :10.1016/j.molcel.2005.10.031 PMID 16364915 . Wichroski MJ, Robb GB, Rana TM (May 2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies" . PLOS Pathogens . 2 (5): e41. doi :10.1371/journal.ppat.0020041 . PMC 1458959 PMID 16699599 . Chu CY, Rana TM (July 2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54" . PLOS Biology . 4 (7): e210. doi :10.1371/journal.pbio.0040210 . PMC 1475773 PMID 16756390 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
