PEX13

PEX13
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1WXU
식별자
별칭	PEX13, NALD, PBD11A, PBD11B, ZWS, 과산화지질 생물 발생 인자 13
외부 ID	OMIM: 601789 MGI: 1919379 호몰로진: 1967 GeneCard: PEX13
유전자 위치(인간)
쳇.	염색체 2 (인간)
끝	61051,990bp
RNA 표현 패턴
	표현된 상단
	2차 난모세포; ; 정자; ; 제르미날 상피; ; 내성 늑막; ; 아킬레스건; ; 두정 늑막; ; 추골결막; ; 강리온의 명성; ; 양수; ; 주황 점막;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0001948 단백질 결합;
셀룰러 컴포넌트	과산화지질의; 과산화막; 막으로 막다; 과산화막의 적분 성분; 세포내 막으로 둘러싸인 오르가넬; 막의 적분 성분; 과산화지질소 복합체;
생물학적 과정	대뇌피질 세포 이동; 단백질 수송; 젖먹이 같은 행동; 지방산 알파포도; 미세관 기반 과산화물 국산화; 기관차적인 행동; 단백질을 과산화물 매트릭스로 가져오기, 도킹; 뉴런의 이동; 운송; 과산화지질을 대상으로 하는 단백질; 단백질의 편재;
	출처:아미고 / 퀵고
직교체
	5194
	72129
	ENSG00000162928
	ENSMUSG00000020283
	Q92968
	Q9D0K1
	NM_002618
	NM_023651
	NP_002609
	NP_076140
	위키다타
인간 보기/편집	마우스 보기/편집

과산화막 단백질 PEX13은 인간에서 PEX13 유전자에 의해 암호화된 단백질이다.^[4]^[5]KIAA1841 옆 2번 염색체에 위치한다.

상호작용

PEX13은 PEX14,^[6] PEX5^[6]^[7] 및 PEX19와 상호작용하는 것으로 나타났다.^[8]^[9]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000162928 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Björkman J, Stetten G, Moore CS, Gould SJ, Crane DI (December 1998). "Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene". Genomics. 54 (3): 521–8. doi:10.1006/geno.1998.5520. PMID 9878256.
^ "Entrez Gene: PEX13 peroxisome biogenesis factor 13".
^ ^a ^b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
^ Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.
^ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
^ Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

추가 읽기

Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.
Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH (April 1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways" (PDF). Cell. 89 (1): 83–92. doi:10.1016/S0092-8674(00)80185-3. PMID 9094717. S2CID 18878596.
Fransen M, Terlecky SR, Subramani S (July 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92. Bibcode:1998PNAS...95.8087F. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144.
Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R (March 1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes". The Journal of Cell Biology. 144 (6): 1151–62. doi:10.1083/jcb.144.6.1151. PMC 2150583. PMID 10087260.
Shimozawa N, Suzuki Y, Zhang Z, Imamura A, Toyama R, Mukai S, et al. (June 1999). "Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders". Human Molecular Genetics. 8 (6): 1077–83. doi:10.1093/hmg/8.6.1077. PMID 10332040.
Toyama R, Mukai S, Itagaki A, Tamura S, Shimozawa N, Suzuki Y, et al. (September 1999). "Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants". Human Molecular Genetics. 8 (9): 1673–81. doi:10.1093/hmg/8.9.1673. PMID 10441330.
Liu Y, Björkman J, Urquhart A, Wanders RJ, Crane DI, Gould SJ (September 1999). "PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders". American Journal of Human Genetics. 65 (3): 621–34. doi:10.1086/302534. PMC 1377968. PMID 10441568.
Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
Jones JM, Morrell JC, Gould SJ (June 2001). "Multiple distinct targeting signals in integral peroxisomal membrane proteins". The Journal of Cell Biology. 153 (6): 1141–50. doi:10.1083/jcb.153.6.1141. PMC 2192020. PMID 11402059.
Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (March 2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Molecular & Cellular Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (March 2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". The Journal of Biological Chemistry. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
Hashimoto K, Kato Z, Nagase T, Shimozawa N, Kuwata K, Omoya K, et al. (August 2005). "Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder". Pediatric Research. 58 (2): 263–9. doi:10.1203/01.PDR.0000169984.89199.69. PMID 16006427.
Nguyen T, Bjorkman J, Paton BC, Crane DI (February 2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". Journal of Cell Science. 119 (Pt 4): 636–45. doi:10.1242/jcs.02776. PMID 16449325.

외부 링크

인간 염색체 2의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000162928 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878256-4] Björkman J, Stetten G, Moore CS, Gould SJ, Crane DI (December 1998). "Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene". Genomics. 54 (3): 521–8. doi:10.1006/geno.1998.5520. PMID 9878256.

[entrez-5] "Entrez Gene: PEX13 peroxisome biogenesis factor 13".

[pmid11865044-6] Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.

[pmid8858165-7] Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.

[pmid10704444-8] Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.

[pmid11390669-9] Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Search

PEX13

네임스페이스

더

목차

상호작용

참조

추가 읽기

외부 링크