PSTPIP2

PSTPIP2
식별자
에일리어스	PSTPIP2, MAYP, 프롤린세린트레오닌포스파타아제상호작용단백질2
외부 ID	OMIM : 616046 MGI : 1335088 HomoloGene : 69150 Genecard : PSTPIP2
유전자 위치(인간)
크르.	18번 염색체(인간)
끝.	46,072,272 bp
RNA발현패턴
	상단 표시 위치:
	비장; ; 단구; ; 골수; ; 피; ; 결석골; ; 골수 세포; ; 위근; ; 상완 이두근; ; 위점막; ; 오른쪽 폐;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	액틴 결합; 세포골격단백질결합; 액틴 필라멘트 결합;
셀룰러 컴포넌트	세포질; 세포; 세포골격; 막; 액틴 필라멘트; 혈장막;
생물학적 과정	세포이동; 세포골격조직; 액틴 필라멘트 중합;
	출처:아미고 / QuickGO
맞춤법
	9050
	19201
	ENSG00000152229
	ENSMUSG000025429
	Q9H939
	문제 99M15
	NM_024430
	NM_013831; NM_177831
	NP_077748
	NP_038859
	위키데이터
인간 보기/편집	마우스 표시/편집

프롤린-세린-트레오닌-포스파타아제 상호작용 단백질 2는 PSTPIP2 ^[4]^[5]유전자에 의해 인체 내에서 암호화되는 효소이다.대식세포 F-액틴 관련 및 티로신인산화단백질(MAYP)로도 알려진 이 단백질은 폼베 Cdc15 호몰로지(PCH) 계열의 단백질로 막과 세포골격역학을 조정하는 것으로 나타났다.

기능.

Pstpip2는 대식세포 및 대식세포 ^[7]^[8]전구체로 선택적으로 발현되며, 필로포디아 형성과 대식세포 운동성을^[9] 조절하는 액틴 결합 단백질이다.

사이토카인 발현 프로파일

PSTPIP2 결핍은 체내 순환 염증 매개체의 수치를 증가시킨다.무증상 마우스에서는 MIP-1α 및 IL-6만 상승하지만, 증상성 PSTPIP2 결핍 마우스에서는 순환 IL-6, MIP-1α, TNF-α, CSF-1 및 IP-10의^[10] 수치가 상승하고 IL-13이^[11]^[12] 감소한다.

질병관련성

미센스 돌연변이 I282N은 대식세포 매개 자기염증성 질환인 Lupo Pstpip2(Pstpip2^Lupo/Lupo)로 이어진다.피부 괴사, 발, 귀, 염증성 뼈 ^[8]흡수가 특징입니다.Pstpip2의 또 다른 돌연변이인 L98P는 만성 다초점 골수염(cmo) 생쥐에서 설명되었다.이 질병은 또한 자가염증성이며 다형핵 백혈구, 대식세포, 림프구, 혈장세포, 골세포의 염증 침투를 일으킨다.나중에 침윤물은 꼬리가 꼬이고 뒷발 기형을 일으키는 새로운 뼈 조직으로 대체된다.cmo 마우스는 또한 표피, 진피, ^[13]연골에 귀염이 생긴다.

상호 작용

PSTPIP2는 프롤린, 글루탐산, 세린 및 트레오닌 리치(^[14]PEST) 계열의 단백질 티로신 포스파타아제, SHIP1 및 Csk와^[15] 상호작용한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000152229 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu Y, Dowbenko D, Lasky LA (November 1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". The Journal of Biological Chemistry. 273 (46): 30487–96. doi:10.1074/jbc.273.46.30487. PMID 9804817.
^ "Entrez Gene: PSTPIP2 proline-serine-threonine phosphatase interacting protein 2".
^ Chitu V, Stanley ER (March 2007). "Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions". Trends in Cell Biology. 17 (3): 145–56. doi:10.1016/j.tcb.2007.01.003. PMID 17296299.
^ Yeung YG, Soldera S, Stanley ER (November 1998). "A novel macrophage actin-associated protein (MAYP) is tyrosine-phosphorylated following colony stimulating factor-1 stimulation". The Journal of Biological Chemistry. 273 (46): 30638–42. doi:10.1074/jbc.273.46.30638. PMID 9804836.
^ ^a ^b Grosse J, Chitu V, Marquardt A, Hanke P, Schmittwolf C, Zeitlmann L, Schropp P, Barth B, Yu P, Paffenholz R, Stumm G, Nehls M, Stanley ER (April 2006). "Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease". Blood. 107 (8): 3350–8. doi:10.1182/blood-2005-09-3556. PMC 1895761. PMID 16397132.
^ Chitu V, Pixley FJ, Macaluso F, Larson DR, Condeelis J, Yeung YG, Stanley ER (June 2005). "The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages". Molecular Biology of the Cell. 16 (6): 2947–59. doi:10.1091/mbc.e04-10-0914. PMC 1142438. PMID 15788569.
^ Chitu V, Ferguson PJ, de Bruijn R, Schlueter AJ, Ochoa LA, Waldschmidt TJ, Yeung YG, Stanley ER (September 2009). "Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice". Blood. 114 (12): 2497–505. doi:10.1182/blood-2009-02-204925. PMC 2746474. PMID 19608749.
^ Doherty TM, Kastelein R, Menon S, Andrade S, Coffman RL (December 1993). "Modulation of murine macrophage function by IL-13". J. Immunol. 151 (12): 7151–60. PMID 7903102.
^ Martinez FO, Sica A, Mantovani A, Locati M (January 2008). "Macrophage activation and polarization". Front. Biosci. 13 (13): 453–61. doi:10.2741/2692. PMID 17981560.
^ Chitu V, Ferguson PJ, de Bruijn R, Schlueter AJ, Ochoa LA, Waldschmidt TJ, Yeung YG, Stanley ER (September 2009). "Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice". Blood. 114 (12): 2497–505. doi:10.1182/blood-2009-02-204925. PMC 2746474. PMID 19608749.
^ Veillette A, Rhee I, Souza CM, Davidson D (March 2009). "PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders". Immunological Reviews. 228 (1): 312–24. doi:10.1111/j.1600-065x.2008.00747.x. PMID 19290936. S2CID 30394426.
^ Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, Otahal P, Alberich-Jorda M, Brdicka T (October 2015). "PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk". Journal of Immunology. 195 (7): 3416–26. doi:10.4049/jimmunol.1401494. PMID 26304991.

추가 정보

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Pope SN, Lee IR (February 2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.

인간 염색체 18번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000152229 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9804817-4] Wu Y, Dowbenko D, Lasky LA (November 1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". The Journal of Biological Chemistry. 273 (46): 30487–96. doi:10.1074/jbc.273.46.30487. PMID 9804817.

[entrez-5] "Entrez Gene: PSTPIP2 proline-serine-threonine phosphatase interacting protein 2".

[6] Chitu V, Stanley ER (March 2007). "Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions". Trends in Cell Biology. 17 (3): 145–56. doi:10.1016/j.tcb.2007.01.003. PMID 17296299.

[7] Yeung YG, Soldera S, Stanley ER (November 1998). "A novel macrophage actin-associated protein (MAYP) is tyrosine-phosphorylated following colony stimulating factor-1 stimulation". The Journal of Biological Chemistry. 273 (46): 30638–42. doi:10.1074/jbc.273.46.30638. PMID 9804836.

[:0-8] Grosse J, Chitu V, Marquardt A, Hanke P, Schmittwolf C, Zeitlmann L, Schropp P, Barth B, Yu P, Paffenholz R, Stumm G, Nehls M, Stanley ER (April 2006). "Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease". Blood. 107 (8): 3350–8. doi:10.1182/blood-2005-09-3556. PMC 1895761. PMID 16397132.

[9] Chitu V, Pixley FJ, Macaluso F, Larson DR, Condeelis J, Yeung YG, Stanley ER (June 2005). "The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages". Molecular Biology of the Cell. 16 (6): 2947–59. doi:10.1091/mbc.e04-10-0914. PMC 1142438. PMID 15788569.

[pmid19608749-10] Chitu V, Ferguson PJ, de Bruijn R, Schlueter AJ, Ochoa LA, Waldschmidt TJ, Yeung YG, Stanley ER (September 2009). "Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice". Blood. 114 (12): 2497–505. doi:10.1182/blood-2009-02-204925. PMC 2746474. PMID 19608749.

[pmid7903102-11] Doherty TM, Kastelein R, Menon S, Andrade S, Coffman RL (December 1993). "Modulation of murine macrophage function by IL-13". J. Immunol. 151 (12): 7151–60. PMID 7903102.

[pmid17981560-12] Martinez FO, Sica A, Mantovani A, Locati M (January 2008). "Macrophage activation and polarization". Front. Biosci. 13 (13): 453–61. doi:10.2741/2692. PMID 17981560.

[13] Chitu V, Ferguson PJ, de Bruijn R, Schlueter AJ, Ochoa LA, Waldschmidt TJ, Yeung YG, Stanley ER (September 2009). "Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice". Blood. 114 (12): 2497–505. doi:10.1182/blood-2009-02-204925. PMC 2746474. PMID 19608749.

[14] Veillette A, Rhee I, Souza CM, Davidson D (March 2009). "PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders". Immunological Reviews. 228 (1): 312–24. doi:10.1111/j.1600-065x.2008.00747.x. PMID 19290936. S2CID 30394426.

[15] Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, Otahal P, Alberich-Jorda M, Brdicka T (October 2015). "PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk". Journal of Immunology. 195 (7): 3416–26. doi:10.4049/jimmunol.1401494. PMID 26304991.

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