RASGRP3

RASGRP3
식별자
에일리어스	RASGRP3, GRP3, RAS구아닐방출단백질3
외부 ID	OMIM: 609531 MGI: 3028579 HomoloGene: 15019 GenCards: RASGRP3
유전자 위치(인간)
크르.	2번 염색체(인간)
끝.	33,564,750 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	75,836,049 bp
RNA발현패턴
	상단 표시 위치:
	뇌량; ; 미주신경의 하부 신경절; ; 시상하핵; ; 내장글로부페리더스; ; 상전정핵; ; 핀; ; 좌심실; ; 림프절; ; 간뇌; ; 흑색 실체;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	칼슘 이온 결합; 구아닐-플루오르화물교환인자활성; GO:0005097, GO:0005099, GO:0005100 GTPase 액티베이터 액티베이션; 신호 변환기 활성; 금속 이온 결합; 키나아제결합; GO:0001948, GO:0016582 단백질 결합; 디아실글리세롤 결합;
셀룰러 컴포넌트	세포질; 혈장막; 혈장막의 적분 성분; 세포질핵주위영역; 구아닐-플루오르화물교환인자복합체; 세포내 해부학적 구조;
생물학적 과정	GO:0007243 세포내 신호 전달; GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 GTPase 액티비티 규제; GTPase 매개 신호 전달; MAPK 캐스케이드; GO:0032320, GO:00321, GO:0032855, GO:0043089, GO:0032854 GTPase 액티비티의 플러스 레귤레이션; Ras단백질신호;
	출처:아미고 / QuickGO
맞춤법
	25780
	240168
	ENSG00000152689
	ENSMUSG000071042
	Q8IV61
	Q6NZH9
NM_001139488; NM_015376; NM_170672; NM_001349975; NM_001349976;
	NM_001349977; NM_001349978; NM_001349979; NM_001349980; NM_001349981
	NM_001166493; NM_207246; NM_001360103
NP_001132960; NP_056191; NP_733772; NP_001336904; NP_001336905;
	NP_001336906; NP_001336907; NP_001336908; NP_001336909; NP_001336910
	NP_001159965; NP_997129; NP_001347032
	위키데이터
인간 보기/편집	마우스 표시/편집

라스구아닐 방출단백질 3은 RASGRP3 ^[5]^[6]^[7]유전자에 의해 인체 내에서 암호화되는 단백질이다.

기능.

GTPases의 RAS 서브패밀리의 멤버(HRAS; MIM 190020 참조)는 비액티브한 GDP와 액티브한 GTP 바운드 상태를 순환하는 GTP/GDP 규제 스위치로서 신호 변환으로 기능합니다.RASGRP3와 같은 구아닌 뉴클레오티드 교환인자(GEFs)는 활성 GTP 결합 상태를 유지하기 위해 GTP의 획득을 촉진함으로써 RAS 활성화제로 작용하며 세포 표면 수용체와 RAS 활성화 사이의 핵심 연결고리이다(Rebun et al.,^[7]

상호 작용

RASGRP3는 PRKCD와 ^[8]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000152689 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000071042 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
^ ^a ^b "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)".
^ Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.

추가 정보

Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Lorenzo PS, Kung JW, Bottorff DA, Garfield SH, Stone JC, Blumberg PM (Feb 2001). "Phorbol esters modulate the Ras exchange factor RasGRP3". Cancer Research. 61 (3): 943–9. PMID 11221888.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC (Aug 2003). "Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3". Blood. 102 (4): 1414–20. doi:10.1182/blood-2002-11-3621. PMID 12730099.
Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Aiba Y, Oh-hora M, Kiyonaka S, Kimura Y, Hijikata A, Mori Y, Kurosaki T (Nov 2004). "Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation". Proceedings of the National Academy of Sciences of the United States of America. 101 (47): 16612–7. doi:10.1073/pnas.0407468101. PMC 528733. PMID 15545601.
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL (Dec 2004). "A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters". Molecular and Cellular Biology. 24 (24): 10515–28. doi:10.1128/MCB.24.24.10515-10528.2004. PMC 533983. PMID 15572660.
Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC (May 2005). "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells". Blood. 105 (9): 3648–54. doi:10.1182/blood-2004-10-3916. PMID 15657177.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Okamura SM, Oki-Idouchi CE, Lorenzo PS (Nov 2006). "The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain". The Journal of Biological Chemistry. 281 (47): 36132–9. doi:10.1074/jbc.M605093200. PMID 17012239.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Randhawa PK, Rylova S, Heinz JY, Kiser S, Fried JH, Dunworth WP, Anderson AL, Barber AT, Chappell JC, Roberts DM, Bautch VL (May 2011). "The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration". Circulation Research. 108 (10): 1199–208. doi:10.1161/CIRCRESAHA.110.230888. PMC 3709466. PMID 21474816.

인간 염색체 2번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000152689 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000071042 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid10934204-6] Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.

[entrez-7] "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)".

[pmid15213298-8] Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.

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RASGRP3

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기능.

상호 작용

레퍼런스

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