Ras 어소시에이션 도메인 함유 단백질 5 는 RASSF5 또는 F5 [5] [6] [7] 단백질 이다.
기능. 이 유전자는 Ras 어소시에이션 도메인 패밀리의 일원입니다. 종양 억제제로서 기능하며, 다양한 암에서 불활성화되지 않습니다. 부호화된 단백질은 중심체와 미세관에 국재하여 Ras, Rap1 및 기타 Ras 유사 소량 GTPas의 GTP 활성화 형태와 관련된다. 단백질은 활성화된 Rap1 또는 Ras에 반응하여 림프구 유착을 조절하고 세포 성장을 억제합니다. 이 [7]
상호 작용 RASSF5는 RRAS ,[8] RAP2A ,[8] MRAS [8] [8] RASSF1 과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000266094 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026430 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenetics and Cell Genetics . 95 (1–2): 126–8. doi :10.1159/000057035 . PMID 11978988 . S2CID 26933977 . ^ Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1" . 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