판코니 빈혈, 보완군 C

사용 가능한 단백질 구조:
Pfam	구조물/ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	구조 요약

판코니 빈혈군 C단백질
판코니 빈혈군 C단백질
식별자
기호	판코니_c
Pfam	PF02106
인터프로	IPR000686
Pfam
사용 가능한 단백질 구조:
Pfam	구조물/ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	구조 요약

팬CC
식별자
별칭	FANCC, Fanc, Fac, FA3, FAS, mir-3074-1, FACC, Fanconi 빈혈보완그룹 C, FA 보완그룹 C
외부 ID	OMIM: 613899 MGI: 95480 HomoloGene: 109 GeneCard: FANCC
유전자 위치(인간)
쳇.	9번 염색체(인간)
끝	95,426,796 bp
유전자 위치(마우스)
쳇.	13번 염색체(쥐)
끝	63,645,092 bp
RNA 표현 패턴
	표현된 상단
	폐를 끼치다; ; 간 우엽; ; 간; ; 뱃속; ; 수근신경; ; 고환; ; 콩팥을;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0001948 단백질 결합;
셀룰러 컴포넌트	세포질; 시토솔; 판코니 빈혈핵단지; 핵의; 핵종의;
생물학적 과정	교차 링크 수리; DNA 수리; DNA 손상 자극에 대한 세포 반응; 골수성 세포의 근상동맥.; 뉴클레오티드-제분 보수; 게이메테 세대; 세균 세포 발달; 과산화수소 제거; 산화 스트레스에 대한 세포 반응; 뇌 형태생성; 뉴런 줄기세포 인구 유지; 단백질 분해 복합체 조립체;
	출처:아미고 / 퀵고
직교체
	2176
	14088
	ENSG00000158169
	ENSMUSG00000021461
	Q00597
	P50652
	NM_000136; NM_001243743; NM_001243744
	NM_001042673; NM_001282942; NM_007985; NM_001347514; NM_001347515
	NP_000127; NP_001230672; NP_001230673
	NP_001036138; NP_001269871; NP_001334443; NP_001334444; NP_032011
	위키다타
인간 보기/편집	마우스 보기/편집

판코니 빈혈군 C단백질(Panconi 빈혈군 C단백질)은 인간에서 FANCC유전자에 의해 암호화된 단백질이다.^[5]^[6]

구조

함수

이 유전자에 의해 암호화된 단백질은 세포사멸의 시작을 지연시키고 손상된 DNA의 동질 재조합 수리를 촉진한다.이 유전자의 돌연변이는 판코니 빈혈의 원인이 된다.^[6]

FANCC 단백질(FANCA, FANCF, FANCG뿐만 아니라 FANCC 단백질도 포함된 핵단지가 단유입성 이소폼에 대한 FANCD2 단백질의 활성화에 필수적이다.^[7]정상적이고 비혼합적인 경우, 세포 FANCD2는 DNA 손상에 반응하여 모노 입화된다.FANCC와 FANCC는 이 반응을 위한 기질 어댑터 역할을 한다. FANCC2 단백질은 감수성 염색체의 시냅토네말 복합체 및 전리방사선 유도 포커스에서 BRCA1(양극암 수용성 단백질)과 공동 국소화한다.활성화된 FANCD2 단백질은 감수성 재조합을 시작하기 전에, 아마도 시냅시스를 위한 염색체를 준비하거나 후속 재조합 사건을 조절하기 위해 기능할 수 있다.^[7]

FANCC(-/-) 돌연변이 수컷과 암컷 생쥐가 생식 발생을 저해해 판코니 빈혈 환자의 특징인 생식기능이 현저하게 손상됐다.^[9]수컷과 암컷 FANCC 돌연변이 쥐 모두 세균 세포 수를 줄였다.^[10]

상호작용

판코니 빈혈, 보충군 C는 다음과 상호작용을 보였다.

Cdk1,^[11]^[12]
FANCA,^[13]^[14]^[15]^[16]^[17]^[18]^[19]^[20]
펜스,^[19]^[21]^[22]^[23]^[24]
FANCF,^[14]^[21]
GSTP1,^[11]^[25]
HSPA1A,^[11]^[26]
SPTAN1,^[13]^[27]
STAT1 ^[11]^[28]^[29]및
ZBTB32.^[11]^[30]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000158169 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000021461 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strathdee CA, Duncan AM, Buchwald M (Jun 1992). "Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9". Nature Genetics. 1 (3): 196–8. doi:10.1038/ng0692-196. PMID 1303234. S2CID 7341515.
^ ^a ^b "Entrez Gene: FANCC Fanconi anemia, complementation group C".
^ ^a ^b Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD (2001). "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway". Mol. Cell. 7 (2): 249–62. doi:10.1016/s1097-2765(01)00173-3. PMID 11239454.
^ van Twest, S; Murphy, VJ; Hodson, C; Tan, W; Swuec, P; O'Rourke, JJ; Heierhorst, J; Crismani, W; Deans, AJ (19 January 2017). "Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway". Molecular Cell. 65 (2): 247–259. doi:10.1016/j.molcel.2016.11.005. PMID 27986371.
^ Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M (1996). "Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia". Nat. Genet. 12 (4): 448–51. doi:10.1038/ng0496-448. PMID 8630504. S2CID 34666783.
^ Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M (1996). "Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene". Blood. 88 (1): 49–58. doi:10.1182/blood.V88.1.49.49. PMID 8704201.
^ ^a ^b ^c ^d ^e Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/s0014-4827(03)00261-1. PMID 14499622.
^ Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD (Aug 1997). "The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2". Blood. 90 (3): 1047–54. doi:10.1182/blood.V90.3.1047. PMID 9242535.
^ ^a ^b McMahon LW, Walsh CE, Lambert MW (Nov 1999). "Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex". The Journal of Biological Chemistry. 274 (46): 32904–8. doi:10.1074/jbc.274.46.32904. PMID 10551855.
^ ^a ^b de Winter JP, van der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, Scheper RJ, Kruyt FA, Hoatlin ME, Joenje H (Nov 2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG". Human Molecular Genetics. 9 (18): 2665–74. doi:10.1093/hmg/9.18.2665. PMID 11063725.
^ Garcia-Higuera I, Kuang Y, Näf D, Wasik J, D'Andrea AD (Jul 1999). "Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex". Molecular and Cellular Biology. 19 (7): 4866–73. doi:10.1128/mcb.19.7.4866. PMC 84285. PMID 10373536.
^ Reuter T, Herterich S, Bernhard O, Hoehn H, Gross HJ (Jan 2000). "Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system". Blood. 95 (2): 719–20. doi:10.1182/blood.V95.2.719. PMID 10627486.
^ Thomashevski A, High AA, Drozd M, Shabanowitz J, Hunt DF, Grant PA, Kupfer GM (Jun 2004). "The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments". The Journal of Biological Chemistry. 279 (25): 26201–9. doi:10.1074/jbc.M400091200. PMID 15082718.
^ Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W (Oct 2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nature Genetics. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351. S2CID 10149290.
^ ^a ^b Taniguchi T, D'Andrea AD (Oct 2002). "The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC". Blood. 100 (7): 2457–62. doi:10.1182/blood-2002-03-0860. PMID 12239156.
^ Otsuki T, Young DB, Sasaki DT, Pando MP, Li J, Manning A, Hoekstra M, Hoatlin ME, Mercurio F, Liu JM (2002). "Fanconi anemia protein complex is a novel target of the IKK signalsome". Journal of Cellular Biochemistry (Submitted manuscript). 86 (4): 613–23. doi:10.1002/jcb.10270. PMID 12210728. S2CID 42471384.
^ ^a ^b Léveillé F, Blom E, Medhurst AL, Bier P, Laghmani el H, Johnson M, Rooimans MA, Sobeck A, Waisfisz Q, Arwert F, Patel KJ, Hoatlin ME, Joenje H, de Winter JP (Sep 2004). "The Fanconi anemia gene product FANCF is a flexible adaptor protein". The Journal of Biological Chemistry. 279 (38): 39421–30. doi:10.1074/jbc.M407034200. PMID 15262960.
^ Gordon SM, Buchwald M (Jul 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems". Blood. 102 (1): 136–41. doi:10.1182/blood-2002-11-3517. PMID 12649160.
^ Medhurst AL, Huber PA, Waisfisz Q, de Winter JP, Mathew CG (Feb 2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway". Human Molecular Genetics. 10 (4): 423–9. doi:10.1093/hmg/10.4.423. PMID 11157805.
^ Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ (Jul 2002). "FANCE: the link between Fanconi anaemia complex assembly and activity". The EMBO Journal. 21 (13): 3414–23. doi:10.1093/emboj/cdf355. PMC 125396. PMID 12093742.
^ Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ, Buchwald M (Jul 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nature Medicine. 7 (7): 814–20. doi:10.1038/89937. PMID 11433346. S2CID 35177844.
^ Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC (Dec 2002). "The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC". The Journal of Biological Chemistry. 277 (51): 49638–43. doi:10.1074/jbc.M209386200. PMID 12397061.
^ McMahon LW, Sangerman J, Goodman SR, Kumaresan K, Lambert MW (Jun 2001). "Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links". Biochemistry. 40 (24): 7025–34. doi:10.1021/bi002917g. PMID 11401546.
^ Pang Q, Fagerlie S, Christianson TA, Keeble W, Faulkner G, Diaz J, Rathbun RK, Bagby GC (Jul 2000). "The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors". Molecular and Cellular Biology. 20 (13): 4724–35. doi:10.1128/mcb.20.13.4724-4735.2000. PMC 85895. PMID 10848598.
^ Pang Q, Christianson TA, Keeble W, Diaz J, Faulkner GR, Reifsteck C, Olson S, Bagby GC (Sep 2001). "The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality". Blood. 98 (5): 1392–401. doi:10.1182/blood.v98.5.1392. PMID 11520787.
^ Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (Dec 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. doi:10.1182/blood.V94.11.3737. PMID 10572087.

추가 읽기

Strathdee CA, Gavish H, Shannon WR, Buchwald M (Apr 1992). "Cloning of cDNAs for Fanconi's anaemia by functional complementation". Nature. 356 (6372): 763–7. Bibcode:1992Natur.356..763S. doi:10.1038/356763a0. PMID 1574115. S2CID 4250632.
Strathdee CA, Gavish H, Shannon WR, Buchwald M (Jul 1992). "Cloning of cDNAs for Fanconi's anaemia by functional complementation". Nature. 358 (6385): 434. Bibcode:1992Natur.358..434S. doi:10.1038/358434a0. PMID 1641028.
Verlander PC, Kaporis A, Liu Q, Zhang Q, Seligsohn U, Auerbach AD (Dec 1995). "Carrier frequency of the IVS4 + 4 A-->T mutation of the Fanconi anemia gene FAC in the Ashkenazi Jewish population". Blood. 86 (11): 4034–8. doi:10.1182/blood.V86.11.4034.bloodjournal86114034. PMID 7492758. {{cite journal}}:날짜 값 확인: year=/ date=불일치(도움말)
Yamashita T, Barber DL, Zhu Y, Wu N, D'Andrea AD (Jul 1994). "The Fanconi anemia polypeptide FACC is localized to the cytoplasm". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6712–6. Bibcode:1994PNAS...91.6712Y. doi:10.1073/pnas.91.14.6712. PMC 44273. PMID 7517562.
Segal GM, Magenis RE, Brown M, Keeble W, Smith TD, Heinrich MC, Bagby GC (Aug 1994). "Repression of Fanconi anemia gene (FACC) expression inhibits growth of hematopoietic progenitor cells". The Journal of Clinical Investigation. 94 (2): 846–52. doi:10.1172/JCI117405. PMC 296166. PMID 7518843.
Youssoufian H (Aug 1994). "Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (17): 7975–9. Bibcode:1994PNAS...91.7975Y. doi:10.1073/pnas.91.17.7975. PMC 44527. PMID 8058745.
Whitney MA, Jakobs P, Kaback M, Moses RE, Grompe M (1994). "The Ashkenazi Jewish Fanconi anemia mutation: incidence among patients and carrier frequency in the at-risk population". Human Mutation. 3 (4): 339–41. doi:10.1002/humu.1380030402. PMID 8081385. S2CID 22001726.
Murer-Orlando M, Llerena JC, Birjandi F, Gibson RA, Mathew CG (Sep 1993). "FACC gene mutations and early prenatal diagnosis of Fanconi's anaemia". Lancet. 342 (8872): 686. doi:10.1016/0140-6736(93)91800-2. PMID 8103176. S2CID 7355624.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Verlander PC, Lin JD, Udono MU, Zhang Q, Gibson RA, Mathew CG, Auerbach AD (Apr 1994). "Mutation analysis of the Fanconi anemia gene FACC". American Journal of Human Genetics. 54 (4): 595–601. PMC 1918103. PMID 8128956.
Whitney MA, Saito H, Jakobs PM, Gibson RA, Moses RE, Grompe M (Jun 1993). "A common mutation in the FACC gene causes Fanconi anaemia in Ashkenazi Jews". Nature Genetics. 4 (2): 202–5. doi:10.1038/ng0693-202. PMID 8348157. S2CID 12160503.
Gibson RA, Buchwald M, Roberts RG, Mathew CG (Jan 1993). "Characterisation of the exon structure of the Fanconi anaemia group C gene by vectorette PCR". Human Molecular Genetics. 2 (1): 35–8. doi:10.1093/hmg/2.1.35. PMID 8490620.
Gavish H, dos Santos CC, Buchwald M (Feb 1993). "A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein". Human Molecular Genetics. 2 (2): 123–6. doi:10.1093/hmg/2.2.123. PMID 8499901.
Youssoufian H, Li Y, Martin ME, Buchwald M (Feb 1996). "Induction of Fanconi anemia cellular phenotype in human 293 cells by overexpression of a mutant FAC allele". The Journal of Clinical Investigation. 97 (4): 957–62. doi:10.1172/JCI118519. PMC 507141. PMID 8613549.
Yamashita T, Wu N, Kupfer G, Corless C, Joenje H, Grompe M, D'Andrea AD (May 1996). "Clinical variability of Fanconi anemia (type C) results from expression of an amino terminal truncated Fanconi anemia complementation group C polypeptide with partial activity". Blood. 87 (10): 4424–32. doi:10.1182/blood.V87.10.4424.bloodjournal87104424. PMID 8639804.
Lo Ten Foe JR, Rooimans MA, Joenje H, Arwert F (1996). "Novel frameshift mutation (1806insA) in exon 14 of the Fanconi anemia C gene, FAC". Human Mutation. 7 (3): 264–5. doi:10.1002/(SICI)1098-1004(1996)7:3<264::AID-HUMU11>3.0.CO;2-0. PMID 8829660.
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Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD (Aug 1997). "The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2". Blood. 90 (3): 1047–54. doi:10.1182/blood.V90.3.1047. PMID 9242535.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

외부 링크

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000158169 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000021461 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1303234-5] Strathdee CA, Duncan AM, Buchwald M (Jun 1992). "Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9". Nature Genetics. 1 (3): 196–8. doi:10.1038/ng0692-196. PMID 1303234. S2CID 7341515.

[entrez-6] "Entrez Gene: FANCC Fanconi anemia, complementation group C".

[Garcia-Higuera-7] Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, Grompe M, D'Andrea AD (2001). "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway". Mol. Cell. 7 (2): 249–62. doi:10.1016/s1097-2765(01)00173-3. PMID 11239454.

[8] van Twest, S; Murphy, VJ; Hodson, C; Tan, W; Swuec, P; O'Rourke, JJ; Heierhorst, J; Crismani, W; Deans, AJ (19 January 2017). "Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway". Molecular Cell. 65 (2): 247–259. doi:10.1016/j.molcel.2016.11.005. PMID 27986371.

[pmid8630504-9] Chen M, Tomkins DJ, Auerbach W, McKerlie C, Youssoufian H, Liu L, Gan O, Carreau M, Auerbach A, Groves T, Guidos CJ, Freedman MH, Cross J, Percy DH, Dick JE, Joyner AL, Buchwald M (1996). "Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia". Nat. Genet. 12 (4): 448–51. doi:10.1038/ng0496-448. PMID 8630504. S2CID 34666783.

[pmid8704201-10] Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M (1996). "Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene". Blood. 88 (1): 49–58. doi:10.1182/blood.V88.1.49.49. PMID 8704201.

[pmid14499622-11] Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/s0014-4827(03)00261-1. PMID 14499622.

[pmid9242535-12] Kupfer GM, Yamashita T, Naf D, Suliman A, Asano S, D'Andrea AD (Aug 1997). "The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2". Blood. 90 (3): 1047–54. doi:10.1182/blood.V90.3.1047. PMID 9242535.

[pmid10551855-13] McMahon LW, Walsh CE, Lambert MW (Nov 1999). "Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex". The Journal of Biological Chemistry. 274 (46): 32904–8. doi:10.1074/jbc.274.46.32904. PMID 10551855.

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[pmid12239156-19] Taniguchi T, D'Andrea AD (Oct 2002). "The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC". Blood. 100 (7): 2457–62. doi:10.1182/blood-2002-03-0860. PMID 12239156.

[pmid12210728-20] Otsuki T, Young DB, Sasaki DT, Pando MP, Li J, Manning A, Hoekstra M, Hoatlin ME, Mercurio F, Liu JM (2002). "Fanconi anemia protein complex is a novel target of the IKK signalsome". Journal of Cellular Biochemistry (Submitted manuscript). 86 (4): 613–23. doi:10.1002/jcb.10270. PMID 12210728. S2CID 42471384.

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[pmid11433346-25] Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ, Buchwald M (Jul 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1". Nature Medicine. 7 (7): 814–20. doi:10.1038/89937. PMID 11433346. S2CID 35177844.

[pmid12397061-26] Pang Q, Christianson TA, Keeble W, Koretsky T, Bagby GC (Dec 2002). "The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC". The Journal of Biological Chemistry. 277 (51): 49638–43. doi:10.1074/jbc.M209386200. PMID 12397061.

[pmid11401546-27] McMahon LW, Sangerman J, Goodman SR, Kumaresan K, Lambert MW (Jun 2001). "Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links". Biochemistry. 40 (24): 7025–34. doi:10.1021/bi002917g. PMID 11401546.

[pmid10848598-28] Pang Q, Fagerlie S, Christianson TA, Keeble W, Faulkner G, Diaz J, Rathbun RK, Bagby GC (Jul 2000). "The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors". Molecular and Cellular Biology. 20 (13): 4724–35. doi:10.1128/mcb.20.13.4724-4735.2000. PMC 85895. PMID 10848598.

[pmid11520787-29] Pang Q, Christianson TA, Keeble W, Diaz J, Faulkner GR, Reifsteck C, Olson S, Bagby GC (Sep 2001). "The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality". Blood. 98 (5): 1392–401. doi:10.1182/blood.v98.5.1392. PMID 11520787.

[pmid10572087-30] Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (Dec 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. doi:10.1182/blood.V94.11.3737. PMID 10572087.

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