프로테아솜엔도펙타아제 복합체

Proteasome endopeptidase complex
프로테아솜엔도펙타아제 복합체
1j2q.jpg
프로테아솜 코어 입자, 딥타머, 아르케아
식별자
EC 번호3.4.25.1
CAS 번호.140879-24-9
데이터베이스
인텐츠IntEnz 뷰
브렌다브렌다 입력
엑스퍼시나이스자이메 뷰
케그KEG 입력
메타사이크대사통로
프리암프로필
PDB 구조RCSB PDB PDBe PDBsum

Proteasome endopeptidase complex (EC 3.4.25.1, ingensin, macropain, multicatalytic endopeptidase complex, prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme.[1][2][3][4]이 효소는 다음과 같은 화학 반응을 촉진한다.

매우 넓은 특수성을 가진 펩타이드 결합의 갈라짐

이 20-S 단백질은 28개의 서브유닛을 7개의 링 중 4개로 배열한 것이다.

참조

  1. ^ Seemüller E, Lupas A, Stock D, Löwe J, Huber R, Baumeister W (April 1995). "Proteasome from Thermoplasma acidophilum: a threonine protease". Science. 268 (5210): 579–82. Bibcode:1995Sci...268..579S. doi:10.1126/science.7725107. PMID 7725107.
  2. ^ Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annual Review of Biochemistry. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
  3. ^ Groll M, Ditzel L, Löwe J, Stock D, Bochtler M, Bartunik HD, Huber R (April 1997). "Structure of 20S proteasome from yeast at 2.4 A resolution". Nature. 386 (6624): 463–71. doi:10.1038/386463a0. PMID 9087403. S2CID 4261663.
  4. ^ Dick TP, Nussbaum AK, Deeg M, Heinemeyer W, Groll M, Schirle M, Keilholz W, Stevanović S, Wolf DH, Huber R, Rammensee HG, Schild H (October 1998). "Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants". The Journal of Biological Chemistry. 273 (40): 25637–46. doi:10.1074/jbc.273.40.25637. PMID 9748229.

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