UBQLN1

UBQLN1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2JY5, 2JY6, 2KLC
식별자
에일리어스	UBQLN1, DA41, DSK2, PLIC-1, UBQN, XDRP1, 유비퀴린 1
외부 ID	OMIM: 605046 MGI: 1860276 HomoloGene: 137258 GenCard: UBQLN1
유전자 위치(인간)
크르.	9번 염색체(인간)
끝.	83,707,958 bp
유전자 위치(마우스)
크르.	13번 염색체(쥐)
끝.	58,363,467 bp
RNA발현패턴
	상단 표시 위치:
	정강이뼈전근; ; 내피 세포; ; 핀; ; 췌상피세포; ; 신경절 융기; ; 자궁내막간질세포; ; 삼각근; ; 이차 난모세포; ; 흉선; ; 척수 신경절;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	폴리유비퀴틴 수식 의존성 단백질 결합; 키나아제결합; GO:0001948 단백질 결합; 동일단백질결합;
셀룰러 컴포넌트	세포질; 막; 혈장막; 핵소체; 귀찮다; 오토파고솜; 소포체; 세포질핵주위영역; 프로테아솜복합체; GO:0016023 세포질 소포; 핵; 세포; 단백질 함유 복합체;
생물학적 과정	악질적인; 저장 작동 칼슘 채널 활성의 음성 조절; 단백질 유비퀴티네이션 조절; 산화스트레스유도내성아포토시스신호경로조절; 소포체 응력에 대한 반응; ER관련 유비퀴틴의존성 단백질 이화작용의 양성조절; 오토파지; 유비퀴틴 의존성 EXT 경로; 단백질 유비퀴티네이션의 양성 조절; 톨라이크 수용체 3 신호 경로의 음성 조절; 저산소증에 대한 세포 반응; GO:0000046 자동고솜 성숙; 오토파고솜 조립체; 거시 자동 식도; 유비퀴틴의존성 단백질 이화 과정; 거시 자동 식도 조절;
	출처:아미고 / QuickGO
맞춤법
	29979
	56085
	ENSG00000135018
	ENSMUSG00000005312
	Q9UMX0
	Q8R317
	NM_013438; NM_053067
	NM_026842; NM_152234
	NP_038466; NP_444295; NP_44295.1
	NP_081118; NP_689420
	위키데이터
인간 보기/편집	마우스 표시/편집

유비퀴린-1은 인간의 UBQLN1 ^[5]^[6]^[7]유전자에 의해 암호화되는 단백질이다.

유비퀴틴은 N 말단 유비퀴틴 유사 도메인과 C 말단 유비퀴틴 관련 도메인의 두 가지 도메인을 포함한다.그들은 물리적으로 프로테아솜과 유비퀴틴 결합효소 둘 다와 관련되므로 기능적으로 유비퀴티네이션 기계를 프로테아솜에 연결하여 생체 내 단백질 분해에 영향을 미치는 것으로 생각된다.

기능들

유비퀴린-1은 단백질 분해 및 잘못 접힌 단백질의 집적과 관련이 있으며 신경변성 ^[8]^[9]질환에 관여할 수 있다.유비퀴린-1은 알츠하이머병과 ^[10]관련된 단백질인 아밀로이드 전구 단백질(APP)의 분자 샤페론 역할을 하는 것으로 보고되었다.

유비퀴린-1은 프레세닐린과의 ^[11]상호작용을 통해 처음 확인되었다.이 ^[7]유전자에 대해 서로 다른 아이소폼을 코드하는 두 개의 전사 변형이 발견되었다.

상호 작용

UBQLN1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000135018 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005312 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S (August 1997). "Identification of a new cellular protein that can interact specifically with DAN". DNA and Cell Biology. 16 (8): 985–91. doi:10.1089/dna.1997.16.985. PMID 9303440.
^ Hanaoka E, Ozaki T, Ohira M, Nakamura Y, Suzuki M, Takahashi E, et al. (Jul 2000). "Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3". Journal of Human Genetics. 45 (3): 188–91. doi:10.1007/s100380050209. PMID 10807547.
^ ^a ^b "Entrez Gene: UBQLN1 ubiquilin 1".
^ Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M (February 2010). "Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation". Biochemical Society Transactions. 38 (Pt 1): 150–5. doi:10.1042/BST0380150. hdl:11858/00-001M-0000-0010-7C06-4. PMID 20074050.
^ Zhang C, Saunders AJ (June 2009). "An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis". Discovery Medicine. 8 (40): 18–22. PMC 3158983. PMID 19772837.
^
Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, et al. (October 2011). "Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein". The Journal of Biological Chemistry. 286 (41): 35689–98. doi:10.1074/jbc.M111.243147. PMC 3195644. PMID 21852239.
- "Alzheimer's brains found to have lower levels of key protein". ScienceDaily (Press release). September 1, 2011.
^ Mah AL, Perry G, Smith MA, Monteiro MJ (November 2000). "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology. 151 (4): 847–62. doi:10.1083/jcb.151.4.847. PMC 2169435. PMID 11076969.
^ Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evolutionary Biology. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.
^ Kim TY, Kim E, Yoon SK, Yoon JB (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochemical and Biophysical Research Communications. 369 (2): 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982.
^ Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J (January 2002). "Characterization of ubiquilin 1, an mTOR-interacting protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1542 (1–3): 41–56. doi:10.1016/S0167-4889(01)00164-1. PMID 11853878.
^ Ko HS, Uehara T, Nomura Y (September 2002). "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death". The Journal of Biological Chemistry. 277 (38): 35386–92. doi:10.1074/jbc.M203412200. PMID 12095988.
^ ^a ^b Mah AL, Perry G, Smith MA, Monteiro MJ (November 2000). "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology. 151 (4): 847–62. doi:10.1083/jcb.151.4.847. PMC 2169435. PMID 11076969.
^ Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, et al. (August 2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Molecular Cell. 6 (2): 409–19. doi:10.1016/S1097-2765(00)00040-X. PMID 10983987.
^ Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

추가 정보

Ozaki T, Kondo K, Nakamura Y, Ichimiya S, Nakagawara A, Sakiyama S (August 1997). "Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5)". Biochemical and Biophysical Research Communications. 237 (2): 245–50. doi:10.1006/bbrc.1997.7122. PMID 9268694.
Ozaki T, Hanaoka E, Naka M, Nakagawara A, Sakiyama S (June 1999). "Cloning and characterization of rat BAT3 cDNA". DNA and Cell Biology. 18 (6): 503–12. doi:10.1089/104454999315222. PMID 10390159.
Wu AL, Wang J, Zheleznyak A, Brown EJ (October 1999). "Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane". Molecular Cell. 4 (4): 619–25. doi:10.1016/S1097-2765(00)80212-9. PMID 10549293.
Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, et al. (August 2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Molecular Cell. 6 (2): 409–19. doi:10.1016/S1097-2765(00)00040-X. PMID 10983987.
Mah AL, Perry G, Smith MA, Monteiro MJ (November 2000). "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology. 151 (4): 847–62. doi:10.1083/jcb.151.4.847. PMC 2169435. PMID 11076969.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, et al. (September 2001). "GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1". Nature Neuroscience. 4 (9): 908–16. doi:10.1038/nn0901-908. PMID 11528422. S2CID 13078743.
Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J (January 2002). "Characterization of ubiquilin 1, an mTOR-interacting protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1542 (1–3): 41–56. doi:10.1016/S0167-4889(01)00164-1. PMID 11853878.
Ko HS, Uehara T, Nomura Y (September 2002). "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death". The Journal of Biological Chemistry. 277 (38): 35386–92. doi:10.1074/jbc.M203412200. PMID 12095988.
Gao L, Tu H, Shi ST, Lee KJ, Asanaka M, Hwang SB, Lai MM (April 2003). "Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase". Journal of Virology. 77 (7): 4149–59. doi:10.1128/JVI.77.7.4149-4159.2003. PMC 150629. PMID 12634373.
Massey LK, Mah AL, Ford DL, Miller J, Liang J, Doong H, Monteiro MJ (February 2004). "Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins". Journal of Alzheimer's Disease. 6 (1): 79–92. doi:10.3233/jad-2004-6109. PMID 15004330.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Persson P, Stockhausen MT, Påhlman S, Axelson H (November 2004). "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells". International Journal of Oncology. 25 (5): 1213–21. doi:10.3892/ijo.25.5.1213. PMID 15492808.
Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, et al. (March 2005). "Family-based association between Alzheimer's disease and variants in UBQLN1". The New England Journal of Medicine. 352 (9): 884–94. doi:10.1056/NEJMoa042765. PMID 15745979.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000135018 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005312 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9303440-5] Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S (August 1997). "Identification of a new cellular protein that can interact specifically with DAN". DNA and Cell Biology. 16 (8): 985–91. doi:10.1089/dna.1997.16.985. PMID 9303440.

[pmid10807547-6] Hanaoka E, Ozaki T, Ohira M, Nakamura Y, Suzuki M, Takahashi E, et al. (Jul 2000). "Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3". Journal of Human Genetics. 45 (3): 188–91. doi:10.1007/s100380050209. PMID 10807547.

[entrez-7] "Entrez Gene: UBQLN1 ubiquilin 1".

[haapasalo_2010-8] Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M (February 2010). "Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation". Biochemical Society Transactions. 38 (Pt 1): 150–5. doi:10.1042/BST0380150. hdl:11858/00-001M-0000-0010-7C06-4. PMID 20074050.

[zhang_2009-9] Zhang C, Saunders AJ (June 2009). "An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis". Discovery Medicine. 8 (40): 18–22. PMC 3158983. PMID 19772837.

[pmid21852239-10] Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, et al. (October 2011). "Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein". The Journal of Biological Chemistry. 286 (41): 35689–98. doi:10.1074/jbc.M111.243147. PMC 3195644. PMID 21852239.
"Alzheimer's brains found to have lower levels of key protein". ScienceDaily (Press release). September 1, 2011.

[11] "Alzheimer's brains found to have lower levels of key protein". ScienceDaily (Press release). September 1, 2011.

[mah_2000-11] Mah AL, Perry G, Smith MA, Monteiro MJ (November 2000). "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology. 151 (4): 847–62. doi:10.1083/jcb.151.4.847. PMC 2169435. PMID 11076969.

[pmid24674348-12] Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evolutionary Biology. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.

[pmid18307982-13] Kim TY, Kim E, Yoon SK, Yoon JB (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochemical and Biophysical Research Communications. 369 (2): 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982.

[pmid11853878-14] Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J (January 2002). "Characterization of ubiquilin 1, an mTOR-interacting protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1542 (1–3): 41–56. doi:10.1016/S0167-4889(01)00164-1. PMID 11853878.

[pmid12095988-15] Ko HS, Uehara T, Nomura Y (September 2002). "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death". The Journal of Biological Chemistry. 277 (38): 35386–92. doi:10.1074/jbc.M203412200. PMID 12095988.

[pmid11076969-16] Mah AL, Perry G, Smith MA, Monteiro MJ (November 2000). "Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation". The Journal of Cell Biology. 151 (4): 847–62. doi:10.1083/jcb.151.4.847. PMC 2169435. PMID 11076969.

[pmid10983987-17] Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, et al. (August 2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Molecular Cell. 6 (2): 409–19. doi:10.1016/S1097-2765(00)00040-X. PMID 10983987.

[18] Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

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Search

UBQLN1

네임스페이스

더

목차

기능들

관련 단백질

상호 작용

레퍼런스

추가 정보