호모 사피엔스 종의 단백질 코드 유전자
E3 SMO-단백질 연결효소 PIAS4는 활성 STAT(PIAS) 단백질의 여러 단백질 억제제 중 하나이다.활성 STAT 단백질 감마(PIASg 또는 PIASy)의 단백질 억제제 로도 알려져 있으며, 사람 에게서 PIAS4 [5] [6] 효소 이다.
상호 작용 PIAS4는 탈구증 호몰로지 [7] 탈구증 호몰로지 [7] 림포이드 강화제 결합인자 [8] 어머니 와 상호작용 하는 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000105229 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000004934 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (Sep 1998). "Inhibition of Stat1-mediated gene activation by PIAS1" . Proc Natl Acad Sci U S A . 95 (18): 10626–31. doi :10.1073/pnas.95.18.10626 PMC 27945 PMID 9724754 . ^ "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4" .^ a b Imoto, Seiyu; Sugiyama Kenji; Muromoto Ryuta; Sato Noriko; Yamamoto Tetsuya; Matsuda Tadashi (Sep 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3" . J. Biol. Chem . 278 (36): 34253–8. doi :10.1074/jbc.M304961200 ISSN 0021-9258 . PMID 12815042 . ^ Sachdev, S; Bruhn L; Sieber H; Pichler A; Melchior F; Grosschedl R (Dec 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies" . Genes Dev . 15 (23): 3088–103. doi :10.1101/gad.944801 . ISSN 0890-9369 . PMC 312834 PMID 11731474 .
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