Sulfotransferase 1A1은 인간에서 SUT1A1유전자에 의해 암호화된 효소다.[3][4][5]null
Sulfotransferase 효소는 많은 호르몬, 신경전달물질, 약물, 그리고 이질생물성 화합물의 황산염의 결합을 촉진한다.이러한 세포질 효소는 조직 분포와 기질 특이성이 다르다.유전자 구조(exon의 수와 길이)는 가족 구성원 간에 유사하다.이 유전자는 온도 조절이 가능한 효소 활성을 가진 두 개의 페놀 설포트란스페라제 중 하나를 암호화한다.이 유전자에 대해 두 개의 ISO 형태를 인코딩하는 여러 개의 대체적으로 분할된 변형이 확인되었다.[5]null
SUT1A1 효소는 모낭의 외근 피복으로 표현된다.미국 FDA가 유일하게 승인한 국소제인 미녹시딜(Androgenic alopeia)이 남녀 패턴 탈모(Androgenic alopeia) 환자에서 탈모를 재성장시키는 약물이다.미녹시딜은 모발 황산페라제 효소(SULT1A1)에 의해 활성형태(미녹시딜황산염)로 전환된다.[6]머리카락에서 황산염화효소 발현에 큰 변화가 관찰된다.저황산소화효소 활성은 모발 재성장을 위한 국소 미녹시딜에 대한 반응이 부족할 것으로 예측되는 것으로 나타났다.[7]임상 연구에서 저산소증 모사 경로를 이용한 새로운 공식은 생체 내 인간 피험자에서 SUT1A1 활성도를 증가시키는 것으로 입증되었다.[8]null
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z, et al. (2015). "Clinical utility and validity of minoxidil response testing in androgenetic alopecia". Dermatologic Therapy. 28 (1): 13–6. doi:10.1111/dth.12164. PMID25112173.
^Ramos PM, McCoy J, Wambier C, Shapiro J, Vañó-Galvan S, Sinclair R, Goren A (May 2020). "Novel topical booster enhances follicular sulfotransferase activity in patients with androgenetic alopecia: a new strategy to improve minoxidil response". Journal of the European Academy of Dermatology and Venereology. doi:10.1111/jdv.16645. hdl:11343/278544. PMID32432358.
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