구문 3

STX3
식별자
에일리어스	STX3, STX3A, Syntaxin 3, MVID2, RDMVID, DIAR12
외부 ID	OMIM: 600876 MGI: 103077 HomoloGene: 80191 GeneCard: STX3
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	59,805,882 bp
유전자 위치(마우스)
크르.	19번 염색체(쥐)
끝.	11,796,767 bp
RNA발현패턴
	상단 표시 위치:
	직장; ; 오른쪽 폐; ; 피; ; 랑게르한스 섬; ; 좌폐 상엽; ; 십이지장; ; 담낭; ; 제주날 점막; ; 이차 난모세포; ; 단구;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	SNAP 수용체 활성; GO:0001948 단백질 결합; 아라키돈산결합; SNARE 바인딩;
셀룰러 컴포넌트	막의 적분 성분; 막; 세포-세포 접합; 성장 원뿔; 분비 과립; 액포; 수상돌기; SNARE 콤플렉스; 아즈로필과립; 특이 과립; 꼭대기 플라즈마막; 뉴런 투영; 세포외 엑소좀; 라멜리포듐; 광수용체세포말단부톤; 리본 시냅스; 시냅스 소포; 시냅스 전막; 흑색체; 자이모겐과립막; 혈장막; 시냅스 후; 내막계; 시냅스전활성대막; 섀퍼 부수물 - CA1 시냅스; 글루탐산성 시냅스;
생물학적 과정	시냅스 소포 도킹; 시냅스 전 활성대막으로의 시냅스 소포 융합; 막융합; 베시클 도킹; 혈장막 단백질 국재 양성 조절; 화학성 양성 조절; 세포군 증식의 양성 조절; 세포표면에 대한 단백질 국재성의 양성조절; 세포내단백질; 신경전달물질수송; 뉴런 투영 발달; 소포체 수송; 세포유착의 양성조절; 장기 시냅스 증강; 세포외부증; 소포 융합; 시냅스 후막으로의 신경전달물질 수용체 외삽입; 운송; 사이토카인결합신호경로; 시냅스에서의 소낭-소체 수송;
	출처:아미고 / QuickGO
맞춤법
	6809
	20908
	ENSG00000166900
	ENSMUSG000041488
	문제 13277
	Q64704
	NM_001178040; NM_004177
NM_001025307; NM_001025308; NM_001286543; NM_011502; NM_1522020;
	NM_001360386
	NP_001171511; NP_004168
	NP_001020478; NP_001273472; NP_035632; NP_689344; NP_001347315
	위키데이터
인간 보기/편집	마우스 표시/편집

STX3로도 알려진 Syntaxin 3은 STX3 ^[6]^[7]유전자에 의해 인간에게 암호화되는 단백질이다^[5].

기능.

이 유전자에 의해 코드된 단백질은 호중구의 ^[6]세포 외세포증에 관여하는 수송 소포를 위한 세포 수용체의 신트랜신 계열의 구성원이다.STX3는 신경세포의 성장에 중요한 역할을 하며 오메가-6 아라키돈산의 직접적인 ^[8]표적 역할을 한다.Syntaxin 3의 돌연변이는 미생물을 포함한 질병을 ^[9]일으킨다.

상호 작용

Syntaxin 3은 SNAP-25,^[10]^[11]^[12] SNAP23^[11]^[12]^[13]^[14] 및 SNAP29와 ^[12]상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000166900 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041488 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
^ ^a ^b Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377.
^ "Entrez Gene: STX3 syntaxin 3".
^ Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature. 440 (7085): 813–7. Bibcode:2006Natur.440..813D. doi:10.1038/nature04598. PMID 16598260. S2CID 4411524.
^ Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S (2014). "Loss of syntaxin 3 causes variant microvillus inclusion disease". Gastroenterology. 147 (1): 65–68.e10. doi:10.1053/j.gastro.2014.04.002. PMID 24726755.
^ Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
^ ^a ^b Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
^ ^a ^b ^c Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
^ Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
^ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.

추가 정보

Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
Morgans CW, Brandstätter JH, Kellerman J, Betz H, Wässle H (1996). "A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina". J. Neurosci. 16 (21): 6713–21. doi:10.1523/JNEUROSCI.16-21-06713.1996. PMC 6579260. PMID 8824312.
Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
Delgrossi MH, Breuza L, Mirre C, Chavrier P, Le Bivic A (1997). "Human syntaxin 3 is localized apically in human intestinal cells". J. Cell Sci. 110 (18): 2207–14. PMID 9378770.
Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.
Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen VM (1998). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell Sci. 111 (17): 2681–8. PMID 9701566.
Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377.
Fasshauer D, Antonin W, Margittai M, Pabst S, Jahn R (1999). "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties" (PDF). J. Biol. Chem. 274 (22): 15440–6. doi:10.1074/jbc.274.22.15440. PMID 10336434. S2CID 2555394.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
Riento K, Kauppi M, Keranen S, Olkkonen VM (2000). "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. doi:10.1074/jbc.275.18.13476. PMID 10788461.
Kauppi M, Wohlfahrt G, Olkkonen VM (2002). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
Imai A, Nashida T, Yoshie S, Shimomura H (2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
Bandyopadhyay BC, Swaim WD, Liu X, Redman RS, Patterson RL, Ambudkar IS (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx". J. Biol. Chem. 280 (13): 12908–16. doi:10.1074/jbc.M410013200. PMID 15623527.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Mol. Biol. Cell. 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000166900 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000041488 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7598732-5] Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.

[pmid10080545-6] Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377.

[entrez-7] "Entrez Gene: STX3 syntaxin 3".

[pmid16598260-8] Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature. 440 (7085): 813–7. Bibcode:2006Natur.440..813D. doi:10.1038/nature04598. PMID 16598260. S2CID 4411524.

[9] Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S (2014). "Loss of syntaxin 3 causes variant microvillus inclusion disease". Gastroenterology. 147 (1): 65–68.e10. doi:10.1053/j.gastro.2014.04.002. PMID 24726755.

[pmid7768895-10] Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.

[pmid8663154-11] Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.

[pmid9852078-12] Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.

[pmid12828989-13] Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.

[pmid9168999-14] Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.

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구문 3

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보