히스톤탈아세틸라아제5 는 HDAC5 [5] [6] [7] 효소 이다.
기능. 히스톤 은 전사 조절, 세포 주기 진행, 발달 사건에서 중요한 역할을 한다.히스톤 아세틸화/탈아세틸화는 염색체 구조를 변화시키고 DNA에 대한 전사 인자 접근에 영향 을 미친다. 이 유전자에 의해 코드된 단백질은 클래스 II 히스톤 탈아세틸화효소/아큐크/아파 계열에 속합니다. 히스톤탈아세틸화효소 활성을 가지며 프로모터 와 결합하면 전사를 억제한다.그것은 HDAC3 패밀리 멤버와만 공면역흡입하며 다중복합단백질을 형성할 수 있다. 또한 근구증강인자-2(MEF2) 단백질과 상호작용하여 MEF2 의존성 유전자를 억제한다. 이 유전자는 대장암과 관련이 있는 것으로 생각된다. 이 [7]
포도당 운반체 GLUT4의 AMP 활성화 단백질인산화효소 조절은 HDAC5의 [8] 인산화 에 의해 일어난다.
HDAC5는 기억력 강화 에 관여하며 알츠하이머병 치료 를 위한 보다 선택적 HDAC 억제제 의 개발은 HDAC5의 [9] 그 기능은 독립적 [10]
HDAC5의 요관암 세포주 과발현은 장기 증식을 억제하지만 상피에서 간엽 전이(EMT )[11]
상호 작용 히스톤탈아세틸화효소 5는 다음과 상호작용하는 것 으로 나타났다.
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