갑상선-호르몬-및 레티노인-산-수용체 관련 공동억제제 1(TRAC-1 )이라고도 하는 핵수용체 공동억제제 1 은 인간에서 NCOR1 [5] [6] 단백질 이다.
NCOR1은 여러 핵 수용체 상호작용 도메인을 포함하는 전사적 상호조절 단백질이다. 또한 NCOR1은 DNA 프로모터 영역에 히스톤 탈아세틸화효소 를 모집하는 것으로 보인다. 따라서 NCOR1은 유전자 [5] [7]
이 단백질의 기능 상실은 마우스 [8]
가족 핵수용체 코어프레서 계열의 일원입니다. 핵수용체 코레프레서 계열의 다른 인간 단백질은 핵수용체 코레프레서 2 입니다.[9]
상호 작용 핵수용체 공동억제기 1은 다음과 상호작용하는 것 으로 나타났다.
안드로겐 [10] [11] [12] [13] CHD1 ,[14] 칼시트리올수용체 [15] [16] GPS2 ,[17] [18] [19] 글루코콜티코이드 [20] [21] HDAC3 ,[17] [18] [19] [22] [23] [24] [25] HDAC4 ,[24] [26] HDAC7A ,[22] HDAC9 ,[27] HEY2 ,[28] 히스톤탈아세틸화효소5 [17] [26] MAP3K7IP2 ,[29] MECP2 ,[30] 퍼옥시좀 증식기 활성화 수용체 [31] 페르옥시좀증식제활성화수용체 감마 골수성 백혈병 단백질,[32] RUNX1T1 ,[33] [34] 레티노인산 수용체 알파,[31] [35] 레티노인산 수용체 [31] SAP30 ,[25] [36] TBL1XR1 ,[17] [18] [19] TBL1X [17] [19] [23] [37] ZBTB33 .[18]
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