근구특이증강인자2A

MEF2A
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1C7U, 1EGW, 1LEW, 3KOV, 3MU6, 3P57
식별자
에일리어스	MEF2A, ADCAD1, RSRFC4, RSRFC9, Mef2, 근세포증강인자2A
외부 ID	OMIM: 600660 MGI: 99532 HomoloGene: 4080 GeneCard: MEF2A
유전자 위치(인간)
크르.	15번 염색체(인간)
끝.	99,716,488 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	67,372,858 bp
RNA발현패턴
	상단 표시 위치:
	아킬레스건; ; 심근; ; 우심실; ; 상완 이두근; ; 중측두회; ; 경골; ; 삼각근; ; 외측 광대근; ; 정강이뼈전근; ; 상완 삼두근;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	배열특이적 DNA결합; GO:0001105 트랜스크립션코액티베이터 액티비티; DNA결합; 단백질 이량화 활성; GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA결합전사활성화제, RNA중합효소II 특이적; 히스톤탈아세틸화효소결합; 크로마틴 결합; GO:0000980 RNA중합효소II 시스조절영역배열특이적 DNA결합; GO:0001948 단백질 결합; 히스톤아세틸전달효소결합; 단백질 헤테로다이머화 활성; 전사인자활성, RNA중합효소II 원위증강제배열특이결합; SMAD 바인딩; 단백질인산화효소결합; RNA중합효소II전사조절영역배열특이적DNA결합; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	전사조절복합체; 핵소체; 핵; 세포;
생물학적 과정	칼슘 이온에 대한 세포 반응; 세포 분화; 전사조절, DNA템플릿화; 미토콘드리아 게놈 유지; 수상돌기 형태 형성; 근육 세포 분화의 양성 조절; 근육 기관의 발달; RNA중합효소II에 의한 전사 음성 조절; 전사, DNA 템플릿; 신경계의 발달; ERK5 캐스케이드; 다세포 생물 발달; 전사의 양성 조절, DNA 템플릿화; 심장 발달; 심장 전도; 미토콘드리아 분포; 심실근섬유조립체; RNA중합효소II에 의한 전사의 양성 조절; 아포토시스 과정; 심근 비대 양성 조절; RNA중합효소II에 의한 전사; MAPK 캐스케이드; 포도당 수입의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	4205
	17258
	ENSG000068305
	ENSMUSG000030557
	Q02078
	문제 60929
NM_001130926; NM_001130927; NM_001130928; NM_001171894; NM_005587;
	NM_001319206; NM_001352614; NM_001352615; NM_001352616; NM_001352617; NM_001352618; NM_001365201; NM_001365202; NM_001365203; NM_001365204; NM_001365205; NM_001365206; NM_001365207; NM_001365208; NM_001365209; NM_001365210; NM_001365211; NM_001393558; NM_001393559; NM_001393560; NM_001393561
NM_001033713; NM_001291191; NM_001291192; NM_001291195; NM_001291196;
	NM_001357324; NM_001357325
NP_001124398; NP_001124399; NP_001124400; NP_001165365; NP_001306135;
	NP_005578; NP_001339543; NP_001339544; NP_001339545; NP_001339546; NP_001339547; NP_001352130; NP_001352131; NP_001352132; NP_001352133; NP_001352134; NP_001352135; NP_001352136; NP_001352137; NP_001352138; NP_001352139; NP_001352140
NP_001028885; NP_001278120; NP_001278121; NP_001278124; NP_001278125;
	NP_001344253; NP_001344254
	위키데이터
인간 보기/편집	마우스 표시/편집

근구특이적 증강인자 2A는 MEF2A ^[5]^[6]유전자에 의해 인간에서 암호화되는 단백질이다.MEF2A는 Mef2 패밀리의 전사 인자입니다.인간의 경우 15q26 염색체에 있다.MEF2A의 특정 돌연변이는 관상동맥질환과 심근경색의 상염색체 우성 형태를 일으킨다.

기능.

중배엽 전구 세포에서 근아세포로 분화하는 과정은 근육 유전자 발현을 조절하는 다양한 조직 특이적 인자의 발견으로 이어졌다.myoD(MIM 159970), myogenin(MIM 159980), MYF5(MIM 159990) 및 MRF4(MIM 159991)를 포함한 근원성 염기성 나선 나선형 단백질은 식별된 인자의 한 종류이다.DNA결합조절단백질의 두 번째 패밀리는 근구특이증강인자-2(MEF2) 패밀리다.이들 단백질 각각은 전부는 아니더라도 많은 근육 특이 유전자의 조절 영역에 존재하는 MEF2 표적 DNA 배열에 결합한다.MEF2 유전자는 보존된 DNA를 공유하는 여러 동종 유전자와 다른 전사인자를 포함하는 MADS 유전자 패밀리(효모 접합형 특이전사인자 MCM1, 식물 동종 유전자 '애그마이트'와 '디피시엔스' 및 인간 혈청 반응인자 SRF(MIM 600589)의 구성원이다.도메인 입력.[OMIM ^[6]제공]

상호 작용

근구특이적 증강인자 2A는 다음과 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000068305 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030557 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B (October 1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors". Genes Dev. 6 (9): 1783–98. doi:10.1101/gad.6.9.1783. PMID 1516833.
^ ^a ^b "Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)".
^ Mao Z, Nadal-Ginard B (June 1996). "Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A". J. Biol. Chem. 271 (24): 14371–5. doi:10.1074/jbc.271.24.14371. PMID 8662987.
^ ^a ^b De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G (February 2003). "p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor". Biochem. J. 369 (Pt 3): 477–84. doi:10.1042/BJ20020057. PMC 1223100. PMID 12371907.
^ ^a ^b Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999). "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". EMBO J. 18 (18): 5099–107. doi:10.1093/emboj/18.18.5099. PMC 1171580. PMID 10487761.
^ ^a ^b ^c Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem. 275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID 10748098.
^ Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (January 1999). "Regulation of the MEF2 family of transcription factors by p38". Mol. Cell. Biol. 19 (1): 21–30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528.
^ Yang SH, Galanis A, Sharrocks AD (June 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors". Mol. Cell. Biol. 19 (6): 4028–38. doi:10.1128/mcb.19.6.4028. PMC 104362. PMID 10330143.
^ Ornatsky OI, McDermott JC (October 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. PMID 8798771.
^ Quinn ZA, Yang CC, Wrana JL, McDermott JC (February 2001). "Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins". Nucleic Acids Res. 29 (3): 732–42. doi:10.1093/nar/29.3.732. PMC 30396. PMID 11160896.

추가 정보

Wang Q (2005). "Advances in the Genetic Basis of Coronary Artery Disease". Current Atherosclerosis Reports. 7 (3): 235–41. doi:10.1007/s11883-005-0012-6. PMC 1783687. PMID 15811259.
Wang Q (2005). "Molecular genetics of coronary artery disease". Curr. Opin. Cardiol. 20 (3): 182–8. doi:10.1097/01.hco.0000160373.77190.f1. PMC 1579824. PMID 15861005.
Funk WD, Wright WE (1992). "Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor". Proc. Natl. Acad. Sci. U.S.A. 89 (20): 9484–8. Bibcode:1992PNAS...89.9484F. doi:10.1073/pnas.89.20.9484. PMC 50156. PMID 1329097.
Pollock R, Treisman R (1992). "Human SRF-related proteins: DNA-binding properties and potential regulatory targets". Genes Dev. 5 (12A): 2327–41. doi:10.1101/gad.5.12a.2327. PMID 1748287.
Molkentin JD, Black BL, Martin JF, Olson EN (1996). "Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins". Cell. 83 (7): 1125–36. doi:10.1016/0092-8674(95)90139-6. PMID 8548800.
Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763.
Mao Z, Nadal-Ginard B (1996). "Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A". J. Biol. Chem. 271 (24): 14371–5. doi:10.1074/jbc.271.24.14371. PMID 8662987.
Suzuki E, Lowry J, Sonoda G, Testa JR, Walsh K (1996). "Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP". Cytogenet. Cell Genet. 73 (3): 244–9. doi:10.1159/000134348. PMID 8697817.
Ornatsky OI, McDermott JC (1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. PMID 8798771.
Black BL, Molkentin JD, Olson EN (1998). "Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2". Mol. Cell. Biol. 18 (1): 69–77. doi:10.1128/mcb.18.1.69. PMC 121453. PMID 9418854.
Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (1999). "Regulation of the MEF2 Family of Transcription Factors by p38". Mol. Cell. Biol. 19 (1): 21–30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528.
Yang SH, Galanis A, Sharrocks AD (1999). "Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors". Mol. Cell. Biol. 19 (6): 4028–38. doi:10.1128/mcb.19.6.4028. PMC 104362. PMID 10330143.
Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, Morisaki T (1999). "Expression of MEF2 genes during human cardiac development". Tohoku J. Exp. Med. 187 (1): 15–23. doi:10.1620/tjem.187.15. PMID 10458488.
Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (1999). "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". EMBO J. 18 (18): 5099–107. doi:10.1093/emboj/18.18.5099. PMC 1171580. PMID 10487761.
Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME (1999). "Neuronal activity-dependent cell survival mediated by transcription factor MEF2". Science. 286 (5440): 785–90. doi:10.1126/science.286.5440.785. PMID 10531066.
Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. Bibcode:2000PNAS...97.4070L. doi:10.1073/pnas.080064097. PMC 18151. PMID 10737771.
Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity" (PDF). J. Biol. Chem. 275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID 10748098. S2CID 39220205.
Youn HD, Grozinger CM, Liu JO (2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". J. Biol. Chem. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.

외부 링크

팩터북 MEF2A

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000068305 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000030557 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1516833-5] Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B (October 1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors". Genes Dev. 6 (9): 1783–98. doi:10.1101/gad.6.9.1783. PMID 1516833.

[entrez-6] "Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)".

[pmid8662987-7] Mao Z, Nadal-Ginard B (June 1996). "Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A". J. Biol. Chem. 271 (24): 14371–5. doi:10.1074/jbc.271.24.14371. PMID 8662987.

[pmid12371907-8] De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G (February 2003). "p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor". Biochem. J. 369 (Pt 3): 477–84. doi:10.1042/BJ20020057. PMC 1223100. PMID 12371907.

[pmid10487761-9] Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999). "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". EMBO J. 18 (18): 5099–107. doi:10.1093/emboj/18.18.5099. PMC 1171580. PMID 10487761.

[pmid10748098-10] Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem. 275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID 10748098.

[pmid9858528-11] Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (January 1999). "Regulation of the MEF2 family of transcription factors by p38". Mol. Cell. Biol. 19 (1): 21–30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528.

[pmid10330143-12] Yang SH, Galanis A, Sharrocks AD (June 1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors". Mol. Cell. Biol. 19 (6): 4028–38. doi:10.1128/mcb.19.6.4028. PMC 104362. PMID 10330143.

[pmid8798771-13] Ornatsky OI, McDermott JC (October 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. PMID 8798771.

[pmid11160896-14] Quinn ZA, Yang CC, Wrana JL, McDermott JC (February 2001). "Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins". Nucleic Acids Res. 29 (3): 732–42. doi:10.1093/nar/29.3.732. PMC 30396. PMID 11160896.

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근구특이증강인자2A

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보

외부 링크