HSPA1B

HSPA1B
HSPA1B
Heat shock protein 70.png
사용 가능한 구조물
PDB직교 검색: PDBe RCSB
식별자
별칭HSPA1B, HSP70-1B, HSP70-2, HSP70.2, 열충격 단백질 제품군 A(HSP70) 멤버 1B, HSPA1, HSPA-1, HSP70-1, HSP72, HSP70.1
외부 IDOMIM: 603012 MGI: 96244 HomoloGene: 74294 GeneCard: HSPA1B
직교체
종인간마우스
엔트레스

3304

193740

앙상블

ENSMUSG000091971

유니프로트

P0DMV8
P0DMV9

Q61696

RefSeq(mRNA)

NM_005346

NM_010479

RefSeq(단백질)

NP_005337
NP_005336
NP_005336
NP_005336.3
NP_005337.2

NP_034609

위치(UCSC)Chr 6: 31.83 – 31.83MbCr 17: 34.97 – 34.97Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

인간유전자 HSPA1B는 Hsp70 단백질 계열의 하나인 열충격 단백질 HSP70-2를 암호화하는 인트론리스 유전자다.[5] 그 유전자는 주조직 적합성 단지에서 염색체 6의 짧은 팔에, HSPA1A과 HSPA1L.[6][7][8]HSPA1A과 HSPA1B 거의 동일한 단백질을 만들어 낸다 두 유사 유전자와 함께 클러스터 때문에 그들의 DNA서열에서 몇몇 차이점들은 거의 전적으로 동의어가 대체 또는 3주요 번역되지 않은 r에 있egion, hHSPA1A에서 70kDa 단백질 1A를 섭취하고 HSPA1B에서 70kDa 단백질 1B를 섭취한다.[6] 이들 유전자에 대한 세 번째 더 변형된 파라로그는 동일한 영역인 HSPA1L에 존재하며, 다른 두 유전자와 90%의 동질감을 공유한다.[8]

함수

열충격 70kDa 단백질 1B는 세포 내 다른 단백질의 구조적 순응을 안정화하고 응력에 의한 집적으로부터 보호함으로써 프로테오스타시를 유지하기 위해 다른 열충격 단백질 및 샤페론 시스템과 협력하는 세포단백질이다.[9] Hsp70s는 또한 아데닌과 우라실 베이스가 풍부한 mRNA를 다른 결합 사이트의 직업 상태와 무관하게 결합하고 안정화하는 것으로 나타났다.[10] 이 단백질은 ATP를 결합시켜 비활성화되고, ADP에 대한 인산소화에 의해 활성화되는데, ADP-ADP 교환을 용이하게 하기 위해 칼륨 이온이 필요하다.[11]

Hsp70-2는 특히 감수분열 시 남성 생식선 세포에서 발달적으로 표현되는데, 여기서 CDC2와 사이클린 B1 사이의 복합체 형성에 필요하다.[12] 이후 정자조 운동성을 가능하게 하는 전문 칼슘 이온 통로인 CatSper 콤플렉스에 편입된다.[13]

임상적 유의성

감수성 세포 주기가 S상 이상으로 진행되기 위해 사이클린 B1과 함께 필요한 이단계를 형성할 수 없는 CDC2가 HSA1B 발현이 교란되었을 때 생쥐에서 불임이 관찰되었다.[14]

변형된 종양 세포에서 열충격 단백질 70kDa 단백질 2의 발현이 난소, 방광 용혈, 유방암에서 빠른 증식, 전이, 세포사멸 억제와 관련되어 있다.[15][16][17] HSPA1B-1267 단일 뉴클레오티드 다형성증을 가진 만성 B형 간염이나 C형 간염 바이러스 감염 환자는 간세포암 발생 위험이 높다.[18]

상호작용

Hsp70-2와 다음과 같은 단백질 사이에 상호작용이 특징지어졌다.

참고 항목

참조

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  2. ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000091971 - 앙상블, 2017년 5월
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외부 링크

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

Stub icon

이 단백질 관련 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.