UBE2D3
UBE2D3
유비퀴틴 결합효소 E2 D3는 인체에서 UBE2 D3 [5][6]유전자에 의해 암호화되는 단백질이다.
기능.
유비퀴틴에 의한 단백질의 변형은 분해를 위해 비정상적이거나 단명한 단백질을 목표로 하는 중요한 세포 메커니즘이다.유비퀴티네이션은 유비퀴틴 활성화 효소 또는 E1s, 유비퀴틴 결합 효소 또는 E2s 및 유비퀴틴 단백질 결합효소, E3s의 최소 세 가지 종류의 효소를 포함한다.이 유전자는 E2 유비퀴틴 결합 효소군의 일원을 암호화한다.이 효소는 E3 유비퀴틴-단백질 연결효소에 의해 유도되는 종양억제단백질 p53의 유비퀴티네이션에서 기능한다.이 유전자에 대해 여러 개의 스플라이스된 전사 변형이 발견되었지만, 일부 변종의 전체 길이 특성은 [6]결정되지 않았다.
상호 작용
UBE2D3는 NEDD4와 [7][8]상호작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000109332 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000078578 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (Dec 1995). "Identification of a family of closely related human ubiquitin conjugating enzymes". The Journal of Biological Chemistry. 270 (51): 30408–14. doi:10.1074/jbc.270.51.30408. PMID 8530467.
- ^ a b "Entrez Gene: UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)".
- ^ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes to Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. S2CID 1653536.
- ^ Wang X, Shi Y, Wang J, Huang G, Jiang X (Sep 2008). "Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation". The Biochemical Journal. 414 (2): 221–9. doi:10.1042/BJ20080674. PMID 18498243.
추가 정보
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