PTPN6

PTPN6
PTPN6
Protein PTPN6 PDB 1fpr.png
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, 단백질 티로신 포스파타아제, 비수용체형 6, 단백질 티로신 포스파타아제
외부 IDOMIM: 176883 MGI: 96055 HomoloGene: 56589 GenCard: PTPN6
맞춤법
종.인간마우스
엔트레즈

5777

15170

앙상블

ENSG00000111679

ENSMUSG00000004266

유니프로트

P29350

P29351

RefSeq(mRNA)

NM_002831
NM_080548
NM_080549

NM_001077705
NM_013545

RefSeq(단백질)

NP_002822
NP_536858
NP_536859

NP_001071173
NP_038573

장소(UCSC)Chr 12: 6.95 ~6.96 MbChr 6: 124.7 ~124.72 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

Src 호몰로지 영역 2 도메인 포함 포스파타아제-1(SHP-1)이라고도 알려진 티로신-단백질 포스파타아제 비수용체 타입 6은 사람에게서 PTPN6 [5]유전자에 의해 코드되는 효소이다.

기능.

이 유전자에 의해 암호화된 단백질은 단백질 티로신 포스파타아제(PTP) 계열의 구성원이다.PTP는 세포 성장, 분화, 유사분열 주기, 그리고 발암성 변형을 포함한 다양한 세포 과정을 조절하는 신호 분자로 알려져 있다.이 PTP의 N 말단부는 단백질 포스포티로신 결합 도메인으로 작용하는 2개의 탠덤 Src 호몰로그(SH2) 도메인을 포함하고, 이 PTP와 그 기질의 상호작용을 매개한다.이 PTP는 주로 조혈세포에서 발현되며 조혈세포에서 여러 신호경로의 중요한 조절자로 기능한다.이 PTP는 조혈세포 시그널링에 관여하는 광범위한 포스포단백질 스펙트럼(예: LIN-CD22-SHP-1 경로)과 상호작용하고 탈인산화하는 것으로 나타났다.이 유전자의 여러 가지 교대로 접합된 변종들이 서로 다른 동질 형태를 코드하는 것으로 [6]보고되었다.

표현

SHP-1 유전자는 상피세포에서 활성화된 P-1과 조혈세포에서 활성화된 P-2의 두 가지 촉진제를 가지고 있다.또한 SHP-1의 발현은 상피세포가 낮고 조혈세포가 많다.암에서는 상피세포의 SHP-1 수치가 증가하고 [7]조혈세포의 SHP-1 수치가 감소한다.

상호 작용

PTPN6은 다음 제품과 상호 작용하는 것으로 나타났습니다.

레퍼런스

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