사이클린 D3

CCND3
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	3G33
식별자
별칭	CCND3, 사이클린 D3
외부 ID	OMIM: 123834 MGI: 88315 HomoloGene: 20419 GeneCard: CCND3
유전자 위치(인간)
쳇.	6번 염색체(인간)
끝	42,050,357 bp
유전자 위치(마우스)
쳇.	17번 염색체(쥐)
끝	47,910,616 bp
RNA 표현 패턴
	표현된 상단
	흉선; ; 핏덩어리; ; 비장의; ; 림프절; ; 단모세포; ; 오른쪽 폐; ; 골수; ; 좌측 폐 상부엽; ; 좌측 부신; ; 폐골.;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	사이클린 유도 단백질 세린/트레오닌 키나아제 활성; GO:0001948 단백질 결합; 단백질 키나아제 결합; 단백질 키나아제 활성; 사이클린 유도 단백질 세린/트레오닌 키나아제 조절기 활동;
셀룰러 컴포넌트	핵종의; 사이클린-배열 단백질 키나아제 홀로엔자임 복합체; 막으로 막다; 핵의; 세포질;
생물학적 과정	T세포증식; 세포 순환; 단백질 인산화 양성 조절; 신호 전달; 사이클린-피복 단백질 세린/트레오닌 키나아제 활성의 양성 조절; 세포 주기 조절; 세포 분열; RNA 중합효소 II에 의한 전사의 음성 조절; 세포 인구증식 규제; 인슐린 수용체 신호 경로 조절; 싸이클린-기타 단백질 세린/트레오닌 키나아제 활성 조절; GO:0007067 유사 세포 주기; 단백질 인산화; 핵분열 규제; 세포 인구 증식에 대한 긍정적인 규제; 세포 주기의 양성 조절; 유사 세포 주기의 G1/S 전이 양성 규제;
	출처:아미고 / 퀵고
직교체
	896
	12445
	ENSG00000112576
	ENSMUSG00000034165
	P30281
	P30282
NM_001136017; NM_001136125; NM_001136126; NM_001287427; NM_001287434;
	NM_001760
	NM_001081635; NM_001081636; NM_007632
NP_001129489; NP_001129597; NP_001129598; NP_001274356; NP_001274363;
	NP_001751
	NP_001075104; NP_001075105; NP_031658
	위키다타
인간 보기/편집	마우스 보기/편집

G1/S 특이 싸이클린-D3는 인간에서 CCND3 유전자에 의해 암호화된 단백질이다.^[5]

함수

이 유전자에 의해 암호화된 단백질은 보존도가 높은 사이클린 계열에 속하는데, 그 구성원은 세포 순환을 통해 단백질의 풍부함을 극적으로 주기적인 것으로 특징지어진다.사이클린은 CDK 키나아제의 조절기 역할을 한다.다른 사이클론들은 각각의 유사성 사건의 시간적 조정에 기여하는 뚜렷한 표현과 분해 패턴을 보여준다.이 사이클린은 CDK4 또는 CDK6의 규제 하위 장치로 기능하며, 셀 사이클 G1/S 전환에 필요한 활동이다.이 단백질은 종양 억제기 단백질 Rb의 인산화 작용과 상호 작용하고 있는 것으로 밝혀졌다.이 사이클린과 관련된 CDK4 활동은 UV 방사선 후 G2상을 통한 세포 주기 진행에 필요한 것으로 보고되었다.^[6]

임상적 유의성

CCND3의 돌연변이는 유방암의 경우와 관련이 있다.^[7]

상호작용

Cyclin D3는 다음과 상호작용하는 것으로 나타났다.

참고 항목

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000112576 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000034165 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (August 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics. 13 (3): 565–74. doi:10.1016/0888-7543(92)90126-D. PMID 1386335.
^ "Entrez Gene: CCND3 cyclin D3".
^ Koboldt, Daniel C.; Fulton, Robert S.; McLellan, Michael D.; Schmidt, Heather; Kalicki-Veizer, Joelle; McMichael, Joshua F.; Fulton, Lucinda L.; Dooling, David J.; Ding, Li; Mardis, Elaine R.; Wilson, Richard K.; Ally, Adrian; Balasundaram, Miruna; Butterfield, Yaron S. N.; Carlsen, Rebecca; Carter, Candace; Chu, Andy; Chuah, Eric; Chun, Hye-Jung E.; Coope, Robin J. N.; Dhalla, Noreen; Guin, Ranabir; Hirst, Carrie; Hirst, Martin; Holt, Robert A.; Lee, Darlene; Li, Haiyan I.; Mayo, Michael; Moore, Richard A.; et al. (2012). "Comprehensive molecular portraits of human breast tumours". Nature. 490 (7418): 61–70. Bibcode:2012Natur.490...61T. doi:10.1038/nature11412. PMC 3465532. PMID 23000897.
^ ^a ^b Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.
^ Zhang S, Cai M, Zhang S, Xu S, Chen S, Chen X, Chen C, Gu J (2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. PMID 12082095.
^ ^a ^b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ ^a ^b ^c Lin J, Jinno S, Okayama H (2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene. 20 (16): 2000–9. doi:10.1038/sj.onc.1204375. PMID 11360184.
^ ^a ^b Zhang Q, Wang X, Wolgemuth DJ (1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology. 140 (6): 2790–800. doi:10.1210/endo.140.6.6756. PMID 10342870.
^ ^a ^b Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L (2003). "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II". J. Biol. Chem. 278 (8): 6355–62. doi:10.1074/jbc.M210697200. PMID 12482873.
^ Meyerson M, Harlow E (1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. 14 (3): 2077–86. doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.
^ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1–3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989. S2CID 16005938.

추가 읽기

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Xiong Y, Menninger J, Beach D, Ward DC (1992). "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins". Genomics. 13 (3): 575–84. doi:10.1016/0888-7543(92)90127-E. PMID 1386336.
Motokura T, Yi HF, Kronenberg HM, McBride OW, Arnold A (1992). "Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13". Cytogenet. Cell Genet. 61 (1): 5–7. doi:10.1159/000133359. PMID 1387066.
Matsuoka S, Yamaguchi M, Matsukage A (1994). "D-type cyclin-binding regions of proliferating cell nuclear antigen". J. Biol. Chem. 269 (15): 11030–6. PMID 7908906.
Meyerson M, Harlow E (1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. 14 (3): 2077–86. doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.
Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (1993). "Physical interaction of the retinoblastoma protein with human D cyclins". Cell. 73 (3): 499–511. doi:10.1016/0092-8674(93)90137-F. PMID 8490963. S2CID 24708871.
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Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Hirai H, Sherr CJ (1996). "Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1". Mol. Cell. Biol. 16 (11): 6457–67. doi:10.1128/MCB.16.11.6457. PMC 231647. PMID 8887674.
Doglioni C, Chiarelli C, Macrí E, Dei Tos AP, Meggiolaro E, Dalla Palma P, Barbareschi M (1998). "Cyclin D3 expression in normal, reactive and neoplastic tissues". J. Pathol. 185 (2): 159–66. doi:10.1002/(SICI)1096-9896(199806)185:2<159::AID-PATH73>3.0.CO;2-0. PMID 9713342.
Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA (1999). "Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo". Mol. Cell. Biol. 19 (1): 353–63. doi:10.1128/mcb.19.1.353. PMC 83893. PMID 9858559.
Gabrielli BG, Sarcevic B, Sinnamon J, Walker G, Castellano M, Wang XQ, Ellem KA (1999). "A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay". J. Biol. Chem. 274 (20): 13961–9. doi:10.1074/jbc.274.20.13961. PMID 10318807.
Zhang Q, Wang X, Wolgemuth DJ (1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology. 140 (6): 2790–800. doi:10.1210/endo.140.6.6756. PMID 10342870.
Bartkova J, Rajpert-de Meyts E, Skakkebaek NE, Bartek J (1999). "D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy". J. Pathol. 187 (5): 573–81. doi:10.1002/(SICI)1096-9896(199904)187:5<573::AID-PATH289>3.0.CO;2-H. PMID 10398124.
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Lin J, Jinno S, Okayama H (2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene. 20 (16): 2000–9. doi:10.1038/sj.onc.1204375. PMID 11360184.
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[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000112576 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000034165 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1386335-5] Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (August 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics. 13 (3): 565–74. doi:10.1016/0888-7543(92)90126-D. PMID 1386335.

[6] "Entrez Gene: CCND3 cyclin D3".

[nature11412-7] Koboldt, Daniel C.; Fulton, Robert S.; McLellan, Michael D.; Schmidt, Heather; Kalicki-Veizer, Joelle; McMichael, Joshua F.; Fulton, Lucinda L.; Dooling, David J.; Ding, Li; Mardis, Elaine R.; Wilson, Richard K.; Ally, Adrian; Balasundaram, Miruna; Butterfield, Yaron S. N.; Carlsen, Rebecca; Carter, Candace; Chu, Andy; Chuah, Eric; Chun, Hye-Jung E.; Coope, Robin J. N.; Dhalla, Noreen; Guin, Ranabir; Hirst, Carrie; Hirst, Martin; Holt, Robert A.; Lee, Darlene; Li, Haiyan I.; Mayo, Michael; Moore, Richard A.; et al. (2012). "Comprehensive molecular portraits of human breast tumours". Nature. 490 (7418): 61–70. Bibcode:2012Natur.490...61T. doi:10.1038/nature11412. PMC 3465532. PMID 23000897.

[pmid14641107-8] Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.

[pmid12082095-9] Zhang S, Cai M, Zhang S, Xu S, Chen S, Chen X, Chen C, Gu J (2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. PMID 12082095.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid11360184-11] Lin J, Jinno S, Okayama H (2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene. 20 (16): 2000–9. doi:10.1038/sj.onc.1204375. PMID 11360184.

[pmid10342870-12] Zhang Q, Wang X, Wolgemuth DJ (1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology. 140 (6): 2790–800. doi:10.1210/endo.140.6.6756. PMID 10342870.

[pmid12482873-13] Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L (2003). "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II". J. Biol. Chem. 278 (8): 6355–62. doi:10.1074/jbc.M210697200. PMID 12482873.

[pmid8114739-14] Meyerson M, Harlow E (1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. 14 (3): 2077–86. doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.

[pmid15327989-15] Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1–3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989. S2CID 16005938.

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사이클린 D3

네임스페이스

더

목차

함수

임상적 유의성

상호작용

참고 항목

참조

추가 읽기