MAPK10
MAPK10
c-Jun N-terminal kinase 3(JNK3)로도 알려진 미토겐활성 단백질 키나제 10은 인간에서 MAPK10 유전자에 의해 인코딩되는 효소다.[5][6][7]
함수
이 유전자에 의해 인코딩된 단백질은 MAP 키나제 계열의 일원이다.MAP 키나제스는 복수의 생화학적 신호의 통합점 역할을 하며 증식, 분화, 전사 규제, 개발 등 매우 다양한 세포 과정에 관여한다.이 단백질은 c-Jun N-단자 키나아제(JNKs)의 뉴런에 특화된 형태다.이 키나아제는 인산화 및 핵 국산화 작용을 통해 뉴런 사멸시 신호 경로에 조절 역할을 한다.수용체 조절 MAP키나제 비계 단백질인 베타아레스틴2는 MAP키나제4(MK4)에 의해 이 키나제의 인산화작용을 자극하는 것으로 밝혀졌다.사이클린 의존성 키나아제 5는 인산화할 수 있고, 이 키나아제의 활동을 억제하는데, 이는 신경 세포사멸을 예방하는 데 중요할 수 있다.구별되는 ISO 양식을 인코딩하는 네 가지 대안으로 분할된 대본 변형들이 보고되었다.[7]
상호작용
MAPK10은 MAPK8과 상호작용하는 것으로 나타났다.IP3.[8][9][10]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000109339 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000046709 - 앙상블, 2017년 5월
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- ^ Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
- ^ Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. PMID 12189133.
추가 읽기
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외부 링크
- MAP 키나세 리소스 .
- PDBe-KB에서 UniProt: P53779(Mitogen-activated 단백질 키나제 10)에 대한 PDB의 모든 구조 정보 개요.
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