STX1A

STX1A
식별자
에일리어스	STX1A, HPC-1, P35-1, STX1, SYN1A, 구문in 1A
외부 ID	OMIM : 186590 MGI : 109355 HomoloGene : 37941 Gene Card : STX1A
유전자 위치(인간)
크르.	7번 염색체(인간)
끝.	73,719,672 bp
유전자 위치(마우스)
크르.	5번 염색체(쥐)
끝.	135,079,954 bp
RNA발현패턴
	상단 표시 위치:
	전전두피질; ; 브로드만 10구역; ; 전두극; ; 배측 전전두피질; ; 브로드만 9구역; ; 뇌하수체; ; 랑게르한스 섬; ; 뇌하수체 전엽; ; 편도체; ; 브로드만 영역 46;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	칼슘채널억제활성; 막전송체결합; 단백질 N말단결합; SNAP 수용체 활성; 키나아제결합; 염화물채널억제활성; 단백질 헤테로다이머화 활성; SNARE 바인딩; GO:0001948 단백질 결합; 미오신 결합; 단백질 도메인 특이 결합; 단백질 고분자 어댑터 활성; 미오신두경 결합; ATP의존성 단백질결합; 칼슘의존성 단백질결합;
셀룰러 컴포넌트	막의 적분 성분; 세포; 막; 시냅스 소포; 시냅토브레빈 2-SNAP-25-syntaxin-1a-complexin II 복합체; 전압 게이트 칼륨 채널 복합체; 혈장막; 시냅스; 시냅스 소포막; 분비 과립; 세포외 영역; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I 복합체; 세포 접합; SNARE 콤플렉스; 세포내 소기관; 뉴런 투영; synaptobrevin 2-SNAP-25-syntaxin-1a 복합체; 악토미오신; GO:0016023 세포질 소포; 시냅스 전막; GO:0097483, GO:0097481 시냅스 후 밀도; 시냅스전활성대막; 핵막; 혈장막의 적분 성분; 축삭; 단백질 함유 복합체; 아크로솜 소포; 시냅스 소포막의 일체 성분; 글루탐산성 시냅스; 시냅스 전막의 적분; 내막계; 세포내 해부학적 구조;
생물학적 과정	세포외부증; 노르에피네프린 분비의 양성 조절; 시냅스 소포 도킹; 세포별 분비; 인슐린 분비 조절; 카테콜아민 분비의 양성 조절; 신경전달물질 분비의 양성 조절; 칼슘이온 의존성 외세포증의 양성 조절; 세포외 조절; 중력에 대한 반응; 베시클 도킹; 흥분성 시냅스 후 전위의 양성 조절; 세포외증의 양성 조절; 세포내단백질; 신경전달물질수송; 소포체 수송; 칼슘이온조절세포외증; 시냅스 소포 프라이밍 조절; 막에 대한 단백질 국재화; 흥분성 시냅스 후 전위 변조; 시냅스 전 활성대막으로의 시냅스 소포 융합; SNARE 복합 어셈블리; 사이토카인결합신호경로; 시냅스성 소포 외세포증; 소포 융합; GO:0010554 신경전달물질 분비; 글루탐산염 분비; 단백질수모일화; 인슐린 분비; 조절성 세포외증; 호르몬 분비; 시냅스 소포내구증; 막융합;
	출처:아미고 / QuickGO
맞춤법
	6804
	20907
	ENSG00000106089
	ENSMUSG00000007207
	문제 16623; Q75ME0
	O35526
	NM_001165903; NM_004603
	NM_016801; NM_001359179
	NP_001159375; NP_004594; NP_004594.1
	NP_058081; NP_001346108
	위키데이터
인간 보기/편집	마우스 표시/편집

Syntaxin-1A는 STX1A ^[5]유전자에 의해 인간에서 암호화되는 단백질이다.

기능.

시냅스 소포는 칼슘 조절된 세포 외전증 동안 분비되는 신경전달물질을 저장한다.신경전달물질 방출의 특이성은 시냅스 전 활성 영역에 시냅스 소포와 칼슘 채널을 모두 위치시켜야 한다.Syntaxins는 이 소포 융접 프로세스에서 기능합니다.

Syntaxin-1A는 슈퍼패밀리의 구문의 멤버입니다.Syntaxins는 시냅스 전 혈장막과 시냅스 소포를 도킹하는 데 관여하는 신경계 특이 단백질이다.Syntaxins는 단일 C 말단 트랜스막 도메인, SNARE(Soluble NSF(N-ethylmaleimide-sensitive fusion protein)-Attachment protain Receptor(H3) 도메인 및 N 말단 조절 도메인(Habc)을 가진다.신택신은 칼슘 의존적인 방식으로 시냅토타그민을 결합하고 C 말단 H3 도메인을 통해 전압 의존적인 칼슘 및 칼륨 채널과 상호작용합니다.Syntaxin-1A는 이온 채널 조절과 시냅스 세포 ^[6]외전증의 핵심 단백질이다.

임상적 의의

신틸리누스 뉴로톡신 타입 C의 기질로서 기능하는 신틸리누스 뉴로톡신 타입 C는 세포 외이증을 차단하는 금속단백질이며 폭발성 세포 ^[7]외이증을 일으키는 알파라트로톡신 수용체를 포함하는 분자복합체에 대한 친화력이 높다.

STX1A의 발현 수준은 윌리엄스 ^[8]증후군의 지능과 직접적으로 관련이 있다.

인터랙티브 패스 맵

아래의 유전자, 단백질 및 대사물을 클릭하여 각각의 기사와 연결하세요.^{[§ 1]}

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alt=도파민성 신경세포의 활성도 편집]

도파민성 뉴런의 니코틴 활성 편집

^ 대화형 경로 맵은 WikiPathways에서 편집할 수 있습니다."NicotineDopaminergic_WP1602".

상호 작용

STX1A는 다음과 상호 작용하는 것으로 나타났습니다.

CPLX1,^[9]^[10]^[11]
CFTR,^[12]^[13]
NAPA,^[14]^[15]
RNF40,^[16]
SCNN1G,^[17]
SLC6A1,^[18]^[19]^[20]
SNAP-25,^[9]^[10]^[14]^[21]^[22]^[23]^[24]^[25]^[26]^[27]^[28]
SNAP23,^[26]^[28]^[29]^[30]^[31]
STXBP1,^[9]^[14]^[22]^[32]^[33]
STXBP5,^[34]^[35]
시스템 1^[36]^[37]
UNC13B,^[38]
VAMP2 ^[9]^[10]^[14]^[33]^[39]^[40]및
VAMP8.^[41]

「」를 참조해 주세요.

구문 입력

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000106089 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000007207 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bennett MK, Calakos N, Scheller RH (July 1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones". Science. 257 (5067): 255–9. Bibcode:1992Sci...257..255B. doi:10.1126/science.1321498. PMID 1321498.
^ "Entrez Gene: STX1A syntaxin 1A (brain)".
^ Zhang R, Maksymowych AB, Simpson LL (July 1995). "Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis". Gene. 159 (2): 293–4. doi:10.1016/0378-1119(95)00152-V. PMID 7622072.
^
Gao MC, Bellugi U, Dai L, Mills DL, Sobel EM, Lange K, Korenberg JR (2010). Toland AE (ed.). "Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex". PLOS ONE. 5 (4): e10292. Bibcode:2010PLoSO...510292G. doi:10.1371/journal.pone.0010292. PMC 2858212. PMID 20422020.
- Brian Maffly (2010-04-22). "U. scientist links one gene to intelligence". The Salt Lake Tribune. Archived from the original on 2010-04-25.
^ ^a ^b ^c ^d Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (August 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". The EMBO Journal. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
^ ^a ^b ^c Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (January 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227. S2CID 17878965.
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^ Naren AP, Nelson DJ, Xie W, Jovov B, Pevsner J, Bennett MK, Benos DJ, Quick MW, Kirk KL (November 1997). "Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms". Nature. 390 (6657): 302–5. Bibcode:1997Natur.390..302N. doi:10.1038/36882. PMID 9384384. S2CID 4395005.
^ Cormet-Boyaka E, Di A, Chang SY, Naren AP, Tousson A, Nelson DJ, Kirk KL (September 2002). "CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (19): 12477–82. Bibcode:2002PNAS...9912477C. doi:10.1073/pnas.192203899. PMC 129470. PMID 12209004.
^ ^a ^b ^c ^d McMahon HT, Missler M, Li C, Südhof TC (October 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
^ Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". The Journal of Biological Chemistry. 270 (28): 16955–61. doi:10.1074/jbc.270.28.16955. PMID 7622514.
^ Chin LS, Vavalle JP, Li L (September 2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". The Journal of Biological Chemistry. 277 (38): 35071–9. doi:10.1074/jbc.M203300200. PMID 12121982.
^ Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER, Benos DJ (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". American Journal of Physiology. Renal Physiology. 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. PMID 14996668.
^ Beckman ML, Bernstein EM, Quick MW (August 1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". The Journal of Neuroscience. 18 (16): 6103–12. doi:10.1523/JNEUROSCI.18-16-06103.1998. PMC 6793212. PMID 9698305.
^ Quick MW (April 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5686–91. Bibcode:2002PNAS...99.5686Q. doi:10.1073/pnas.082712899. PMC 122832. PMID 11960023.
^ Deken SL, Beckman ML, Boos L, Quick MW (October 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nature Neuroscience. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172. S2CID 11312913.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ ^a ^b Hata Y, Südhof TC (June 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
^ Gonelle-Gispert C, Molinete M, Halban PA, Sadoul K (September 2000). "Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells". Journal of Cell Science. 113 ( Pt 18) (18): 3197–205. doi:10.1242/jcs.113.18.3197. PMID 10954418.
^ Ilardi JM, Mochida S, Sheng ZH (February 1999). "Snapin: a SNARE-associated protein implicated in synaptic transmission". Nature Neuroscience. 2 (2): 119–24. doi:10.1038/5673. PMID 10195194. S2CID 25524692.
^ Li Y, Chin LS, Weigel C, Li L (November 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". The Journal of Biological Chemistry. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.
^ ^a ^b Ravichandran V, Chawla A, Roche PA (June 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
^ Chapman ER, An S, Barton N, Jahn R (November 1994). "SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils". The Journal of Biological Chemistry. 269 (44): 27427–32. doi:10.1016/S0021-9258(18)47003-2. PMID 7961655.
^ ^a ^b Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
^ Imai A, Nashida T, Yoshie S, Shimomura H (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
^ Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
^ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
^ Bhaskar K, Shareef MM, Sharma VM, Shetty AP, Ramamohan Y, Pant HC, Raju TR, Shetty KT (January 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochemistry International. 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. PMID 12963086. S2CID 23783141.
^ ^a ^b Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.
^ Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
^ Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, Yokoyama S, Nishioka H, Matsuura Y, Mizoguchi A, Scheller RH, Takai Y (May 1998). "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process". Neuron. 20 (5): 905–15. doi:10.1016/S0896-6273(00)80472-9. PMID 9620695. S2CID 12597505.
^ Shao X, Li C, Fernandez I, Zhang X, Südhof TC, Rizo J (January 1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch". Neuron. 18 (1): 133–42. doi:10.1016/S0896-6273(01)80052-0. PMID 9010211. S2CID 17947552.
^ Thomas DM, Ferguson GD, Herschman HR, Elferink LA (July 1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Molecular Biology of the Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
^ Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
^ Margittai M, Otto H, Jahn R (March 1999). "A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains". FEBS Letters. 446 (1): 40–4. doi:10.1016/S0014-5793(99)00028-9. PMID 10100611. S2CID 9115709.
^ Hao JC, Salem N, Peng XR, Kelly RB, Bennett MK (March 1997). "Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes". The Journal of Neuroscience. 17 (5): 1596–603. doi:10.1523/JNEUROSCI.17-05-01596.1997. PMC 6573372. PMID 9030619.
^ Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamaguchi S, Ni J, Itagaki E, Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". Journal of Cell Science. 114 (Pt 1): 219–227. doi:10.1242/jcs.114.1.219. PMID 11112705.

추가 정보

Peters KW, Qi J, Johnson JP, Watkins SC, Frizzell RA (2002). "Role of snare proteins in CFTR and ENaC trafficking". Pflügers Archiv. 443 Suppl 1: S65–9. doi:10.1007/s004240100647. PMID 11845306. S2CID 21790638.
Wilson DW, Whiteheart SW, Wiedmann M, Brunner M, Rothman JE (May 1992). "A multisubunit particle implicated in membrane fusion". The Journal of Cell Biology. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.
McMahon HT, Missler M, Li C, Südhof TC (October 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
Zhang R, Maksymowych AB, Simpson LL (July 1995). "Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis". Gene. 159 (2): 293–4. doi:10.1016/0378-1119(95)00152-V. PMID 7622072.
Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". The Journal of Biological Chemistry. 270 (28): 16955–61. doi:10.1074/jbc.270.28.16955. PMID 7622514.
Hata Y, Südhof TC (June 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
Pevsner J, Hsu SC, Scheller RH (February 1994). "n-Sec1: a neural-specific syntaxin-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 91 (4): 1445–9. Bibcode:1994PNAS...91.1445P. doi:10.1073/pnas.91.4.1445. PMC 43176. PMID 8108429.
Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
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Shao X, Li C, Fernandez I, Zhang X, Südhof TC, Rizo J (January 1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch". Neuron. 18 (1): 133–42. doi:10.1016/S0896-6273(01)80052-0. PMID 9010211. S2CID 17947552.
Hao JC, Salem N, Peng XR, Kelly RB, Bennett MK (March 1997). "Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes". The Journal of Neuroscience. 17 (5): 1596–603. doi:10.1523/JNEUROSCI.17-05-01596.1997. PMC 6573372. PMID 9030619.
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Osborne LR, Soder S, Shi XM, Pober B, Costa T, Scherer SW, Tsui LC (August 1997). "Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome". American Journal of Human Genetics. 61 (2): 449–52. doi:10.1086/514850. PMC 1715888. PMID 9311751.
Naren AP, Nelson DJ, Xie W, Jovov B, Pevsner J, Bennett MK, Benos DJ, Quick MW, Kirk KL (November 1997). "Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms". Nature. 390 (6657): 302–5. Bibcode:1997Natur.390..302N. doi:10.1038/36882. PMID 9384384. S2CID 4395005.
Okamoto M, Südhof TC (December 1997). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis". The Journal of Biological Chemistry. 272 (50): 31459–64. doi:10.1074/jbc.272.50.31459. PMID 9395480.
Shuang R, Zhang L, Fletcher A, Groblewski GE, Pevsner J, Stuenkel EL (February 1998). "Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings". The Journal of Biological Chemistry. 273 (9): 4957–66. doi:10.1074/jbc.273.9.4957. PMID 9478941.
Vinogradova TI (January 1977). "[Destructive tuberculosis of the lung in adolescents]". Problemy Tuberkuleza (in Russian) (1): 19–22. PMID 834751.
Burgess RW, Deitcher DL, Schwarz TL (August 1997). "The synaptic protein syntaxin1 is required for cellularization of Drosophila embryos". The Journal of Cell Biology. 138 (4): 861–75. doi:10.1083/jcb.138.4.861. PMC 2138053. PMID 9265652.
Littleton JT, Chapman ER, Kreber R, Garment MB, Carlson SD, Ganetzky B (August 1998). "Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly". Neuron. 21 (2): 401–13. doi:10.1016/S0896-6273(00)80549-8. PMID 9728921. S2CID 15119362.
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외부 링크

PDB for UniProt: P32851(Rat Syntaxin-1A)에서 PDBe-KB에 있는 모든 구조 정보의 개요.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[WikiPathways-9] 대화형 경로 맵은 WikiPathways에서 편집할 수 있습니다."NicotineDopaminergic_WP1602".

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000106089 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000007207 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1321498-5] Bennett MK, Calakos N, Scheller RH (July 1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones". Science. 257 (5067): 255–9. Bibcode:1992Sci...257..255B. doi:10.1126/science.1321498. PMID 1321498.

[6] "Entrez Gene: STX1A syntaxin 1A (brain)".

[pmid7622072-7] Zhang R, Maksymowych AB, Simpson LL (July 1995). "Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis". Gene. 159 (2): 293–4. doi:10.1016/0378-1119(95)00152-V. PMID 7622072.

[pmid20422020-8] Gao MC, Bellugi U, Dai L, Mills DL, Sobel EM, Lange K, Korenberg JR (2010). Toland AE (ed.). "Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex". PLOS ONE. 5 (4): e10292. Bibcode:2010PLoSO...510292G. doi:10.1371/journal.pone.0010292. PMC 2858212. PMID 20422020.
Brian Maffly (2010-04-22). "U. scientist links one gene to intelligence". The Salt Lake Tribune. Archived from the original on 2010-04-25.

[10] Brian Maffly (2010-04-22). "U. scientist links one gene to intelligence". The Salt Lake Tribune. Archived from the original on 2010-04-25.

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[pmid12200427-12] Hu K, Carroll J, Rickman C, Davletov B (November 2002). "Action of complexin on SNARE complex". The Journal of Biological Chemistry. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.

[pmid9384384-13] Naren AP, Nelson DJ, Xie W, Jovov B, Pevsner J, Bennett MK, Benos DJ, Quick MW, Kirk KL (November 1997). "Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms". Nature. 390 (6657): 302–5. Bibcode:1997Natur.390..302N. doi:10.1038/36882. PMID 9384384. S2CID 4395005.

[pmid12209004-14] Cormet-Boyaka E, Di A, Chang SY, Naren AP, Tousson A, Nelson DJ, Kirk KL (September 2002). "CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (19): 12477–82. Bibcode:2002PNAS...9912477C. doi:10.1073/pnas.192203899. PMC 129470. PMID 12209004.

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[pmid7622514-16] Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". The Journal of Biological Chemistry. 270 (28): 16955–61. doi:10.1074/jbc.270.28.16955. PMID 7622514.

[pmid12121982-17] Chin LS, Vavalle JP, Li L (September 2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". The Journal of Biological Chemistry. 277 (38): 35071–9. doi:10.1074/jbc.M203300200. PMID 12121982.

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[pmid11960023-20] Quick MW (April 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5686–91. Bibcode:2002PNAS...99.5686Q. doi:10.1073/pnas.082712899. PMC 122832. PMID 11960023.

[pmid11017172-21] Deken SL, Beckman ML, Boos L, Quick MW (October 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nature Neuroscience. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172. S2CID 11312913.

[pmid16169070-22] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

[pmid7768895-23] Hata Y, Südhof TC (June 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.

[pmid10954418-24] Gonelle-Gispert C, Molinete M, Halban PA, Sadoul K (September 2000). "Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells". Journal of Cell Science. 113 ( Pt 18) (18): 3197–205. doi:10.1242/jcs.113.18.3197. PMID 10954418.

[pmid10195194-25] Ilardi JM, Mochida S, Sheng ZH (February 1999). "Snapin: a SNARE-associated protein implicated in synaptic transmission". Nature Neuroscience. 2 (2): 119–24. doi:10.1038/5673. PMID 10195194. S2CID 25524692.

[pmid11524423-26] Li Y, Chin LS, Weigel C, Li L (November 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". The Journal of Biological Chemistry. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.

[pmid8663154-27] Ravichandran V, Chawla A, Roche PA (June 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.

[pmid7961655-28] Chapman ER, An S, Barton N, Jahn R (November 1994). "SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils". The Journal of Biological Chemistry. 269 (44): 27427–32. doi:10.1016/S0021-9258(18)47003-2. PMID 7961655.

[pmid9852078-29] Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.

[pmid12828989-30] Imai A, Nashida T, Yoshie S, Shimomura H (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.

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[pmid12963086-33] Bhaskar K, Shareef MM, Sharma VM, Shetty AP, Ramamohan Y, Pant HC, Raju TR, Shetty KT (January 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochemistry International. 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. PMID 12963086. S2CID 23783141.

[pmid12093152-34] Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.

[pmid12832401-35] Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

[pmid9620695-36] Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, Yokoyama S, Nishioka H, Matsuura Y, Mizoguchi A, Scheller RH, Takai Y (May 1998). "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process". Neuron. 20 (5): 905–15. doi:10.1016/S0896-6273(00)80472-9. PMID 9620695. S2CID 12597505.

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Search

STX1A

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