이 유전자에 의해 암호화된 단백질은 케라틴 계열의 일원이다. 케라틴은 상피세포의 구조적 무결성을 담당하는 중간 필라멘트 단백질로 사이토케라틴과 모발 케라틴으로 세분된다. I형 사이토케라틴은 이질성 케라틴 체인의 쌍으로 배열된 산성 단백질로 이루어져 있다. I형 사이토케라틴 유전자는 17q12-q21 염색체 영역에 군집한다.[7]
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