PD-168,077

PD-168,077
PD-168,077
PD-168,077 Structure.svg
식별자
  • N-([4-(2-시아노페닐)피페라진-1-yl]메틸)-3-메틸벤자미드
펍켐 CID
IUPHAR/BPS
켐스파이더
켐벨
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C20H22N4O
어금질량334.423 g·190−1
3D 모델(JSmol)
  • Cc2cc(ccc2)C(=O)NCN(CC3)CCN3c1ccc1C#n
  • InChI=1S/C20H22N4O/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21/h2-8,13H,9-12,15H2,1H3,(H,22,25) ☒N
  • 키:DNULYRGWFLJQL-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

PD-168,077은 D4 하위타입에 선택적으로 도파민 작용제 역할을 하는 약으로,[1][2] 특히 학습과 기억과 관련된 [3][4][5]D 수용체의4 역할을 연구하는데 사용된다.[6]쥐에게 음경근절을 유도하는 경향은 이것 또한 사용할 수 있다는 것을 의미한다.[7]

참조

  1. ^ Clifford JJ, Waddington JL (May 2000). "Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists". Neuropsychopharmacology. 22 (5): 538–44. doi:10.1016/S0893-133X(99)00141-4. PMID 10731629.
  2. ^ Matulenko MA, Hakeem AA, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO (July 2004). "Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists". Bioorganic & Medicinal Chemistry. 12 (13): 3471–83. doi:10.1016/j.bmc.2004.04.035. PMID 15186832.
  3. ^ Wang X, Zhong P, Gu Z, Yan Z (October 2003). "Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex". Journal of Neuroscience. 23 (30): 9852–61. doi:10.1523/JNEUROSCI.23-30-09852.2003. PMC 6740894. PMID 14586014.
  4. ^ Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (October 2006). "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". The European Journal of Neuroscience. 24 (7): 2021–30. doi:10.1111/j.1460-9568.2006.05043.x. PMID 17067298. S2CID 36871301.
  5. ^ Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR (March 2007). "Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin". Neuropharmacology. 52 (3): 1034–43. doi:10.1016/j.neuropharm.2006.10.019. PMID 17164075. S2CID 36595888.
  6. ^ Bernaerts P, Tirelli E (June 2003). "Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice". Behavioural Brain Research. 142 (1–2): 41–52. doi:10.1016/S0166-4328(02)00371-6. PMID 12798264. S2CID 21960608.
  7. ^ Melis, Maria Rosaria; Succu, Salvatora; Sanna, Fabrizio; Melis, Tiziana; Mascia, Maria Stefania; Enguehard-Gueiffier, Cécile; Hubner, Harald; Gmeiner, Peter; Gueiffier, Alain; Argiolas, Antonio (2006). "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". European Journal of Neuroscience. 24 (7): 2021–2030. doi:10.1111/j.1460-9568.2006.05043.x. ISSN 0953-816X.


Stub icon

신경계통에 관한 이 약물 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.