만노스결합단백질관련단백질가수분해효소2 (MASP-2)라고도 알려진 만난결합 렉틴세린단백질가수분해효소2 는 MASP2유전자 에 [5] [6] [7] 효소 이다.
기능. Ra-반응인자(RARF)는 특정 장내박테리아에 의해 발현 되는 Ra 및 R2 다당류 에 결합하는 보체 의존성 살균인자이다. 이 유전자의 대체 스플라이싱은 보체 활성화 의 마난 결합 렉틴 경로에 관여하는 두 개의 RARF 성분을 코드하는 두 개의 전사 변형을 초래한다. 긴 아이소폼은 2개의 체인으로 분할되어 이황화물 결합에 의해 연결된 헤테로디머를 형성합니다. 암호화된 단백질은 펩티드가수분해효소의 [5] 트립신 계열의 구성원이다.
MASP-2는 보완 시스템 에 관여합니다. MASP-2는 고전적인 보체 경로의 C1s 분자와 매우 유사하며, 그들은 공통의 진화적 조상을 가지고 있는 것으로 생각된다. MBL의 탄수화물 인식 헤드가 병원체 표면에 특이하게 배열된 만노스 잔기에 결합하면 MASP-2가 활성화되어 보체 성분 C4 및 C2가 C4a, C4b, C2a, C2b로 분해된다.
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외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
PDB 갤러리
1q3x : 인간 MASP-2의 촉매영역 결정구조
1szb : 인간 MBL 관련 단백질 19(MAP19)의 결정구조
1zjk : 인간 MASP-2의 자이모겐 촉매영역의 결정구조
