알파-4 베타-2 니코틴 수용체

Alpha-4 beta-2 nicotinic receptor

α4β2 수용체라고도 하는 알파-4 베타-2 니코틴 수용체는 학습에 관여하는 니코틴 아세틸콜린 수용체의 일종으로 [1]α4와 β2 서브유닛으로 구성되어 있다.[2]뇌에 위치하며, 활성화는 주로+ Na와+ K 투과성 증가에 의해 시냅스 후와 사전 흥분 상태를 산출한다.[2]

이 수용체 아형의 자극은 성장 호르몬 분비와도 관련이 있다.CHRNA4 돌연변이 Ser248Pep은 평균보다 10cm(4인치) 짧고 비만이 되기 쉽다.[3]A2015년 리뷰는 그 뇌의α4β2 니코틴성 수용체의 자극 주의 공연에서 특정한 개선에 대한 책임이 있으면 니코틴성 수용체 특이한 가운데[4], 니코틴은 니코틴의 중독성이 필요한 적절한 중재하는은 생물학적 목표를 α4β2 수용체(ki=1 nM), 가장 높은 곳에 바인딩 관련성을 가지고 있다고 언급했다.관계.[5]

수용체는 다음 두 가지 확률로 존재한다.

  • (α4)(2β2) 3수용체는 니코틴에 대한 민감도가 높고 Ca2+ 투과성이 낮다(HS 수용체)
  • (α4)(3β2) 2수용체는 니코틴에 대한 민감도가 낮고 Ca2+ 투과성이 높다(LS 수용체)

구조

(α4)(2β2) 3수용체의 X선 구조는 2016년부터[6] 알려져 있으며, 서브유닛의 원형 α–β–β–α–β 순서를 밝히고 있다.

리간즈

고민자

PAMs

반목자

NAMs

참고 항목

참조

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