"HveA"는 여기서 리다이렉트 됩니다. Harbourview Estates A에 대해서는 토론토 CityPlace를 참조 하십시오. 종양괴사인자수용체슈퍼패밀리멤버14 (TNFRSF14 )라고도 불리는 헤르페스바이러스 엔트리메디에이터 (HVEM )는 TNF수용체슈퍼패밀리 의 [5] [6] [7] [8] 인간세포표면수용체 이다.
명명법 이 단백질은 원래 헤르페스 바이러스 진입 매개체 A(HveA )로 알려져 있었으며, HveB 와 HveC 는 면역글로불린 슈퍼패밀리의 구조적으로 관련이 없는 단백질이다. 분화 분류 클러스터 에서는 CD270이라고 도 합니다.또한 ATAR (다른 TRAF 관련 수용체)이라고도 한다.
기능. 이 유전자에 의해 암호화된 단백질은 TNF 수용체 슈퍼패밀리의 구성원이다. 이 수용체의 세포질 영역은 면역 [7] TNF 수용체 관련 인자(TRAF) 패밀리 멤버와 결합하는 것으로 확인되었다.
멜라노사이트 세포에서 TNFRSF14 유전자 발현은 MITF에 [9] 의해 조절될 수 있다.
상호 작용 TNFRSF14는 TRAF2 ,[10] [11] TNFSF14 [12] [13] [10] [11] TRAF5 와 상호작용하는 것 으로 나타났습니다.
임상 관련성 이 유전자의 돌연변이는 확산성 B세포 림프종 과[14] [15] 소아형 모낭 [16] 림프종 의 경우 와 동시에 연관되어 왔다.
이 수용체는 단순 헤르페스 바이러스 (HSV) 진입의 세포 매개체로 확인되었다. 이 수용체 단백질에 대한 HSV 바이러스 외피 당단백 D(gD)의 결합은 바이러스 진입 [7]
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PDB 갤러리
1jma : 세포수용체 HVEA/HVEM에 결합된 단순 헤르페스 바이러스 당단백 D의 결정구조
2aw2 : 인간 BTLA-HVEM 복합체의 결정 구조
케모카인 CSF
간섭체
IFNAR (α/β, I) 어거니스트: 알비테론 인터페론 알파(인터페론 알파, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )인터페론 알파 2a 인터페론 알파 2b 인터페론 알파 n1 인터페론 알파콘 간섭 알파-n3 간섭 베타(IFN-β)( IFNB1 , IFNB3 )간섭 베타 1a 간섭 베타 1b Interferon kappa(IFN-'/'/'/'/'/', IFNK') 간섭 오메가(IFN-γ, IFNW1) 페긴터페론 알파-2a 페긴터페론 알파-2b IFNGR(,, II) IFNLR(,, III) 여기서 IL-28R(IFNLR)을 참조해 주세요.
인터류킨 TGFβ TNF 다른이들
이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
