FGF1
FGF1
산성섬유아세포성장인자(aFGF)로도 알려진 FGF1은 FGF1 [5][6]유전자에 의해 암호화된 성장인자 및 신호 단백질이다.비글리코실화 17~18kDa 단백질의 성숙한 형태인 155 아미노산 폴리펩타이드로 합성된다.섬유아세포 성장인자 단백질은 1975년에 처음 정제되었으나, 곧 다른 조건들을 사용하여 산성 FGF, 헤파린 결합 성장인자-1 [7]및 내피세포 성장인자-1을 분리하였다.유전자 염기서열 분석 결과 이 그룹은 실제로 같은 성장인자였으며 FGF1은 FGF 단백질 계열의 일원이었다.
FGF-1은 명확한 신호 배열을 가지고 있지 않기 때문에 고전적인 경로를 통해 분비되지 않지만, 세포막(S100A13 및 Syt1)에서 단백질 복합체와 결합하는 이황화물 연결 이합체를 형성하고, 세포막([8][9]S100A13 및 Syt1)을 통해 세포 외부로 플립하는 것을 돕는 것으로 보인다.일단 주변조직의 환원조건에서 이합체는 단량체 FGF1로 해리되며, 이 단량체 FGF1은 전신순환에 들어가거나 세포외기질의 헤파란 황산프로테오글리칸과 결합하는 조직에 격리된다.FGF1은 그 자체가 밀접하게 관련된 [10]분자군을 구성하는 특정 섬유아세포 성장인자 수용체(FGFR) 단백질에 결합하여 그 효과를 발휘할 수 있다.
FGF1은 세포외 활성 외에 세포내에서도 기능할 수 있다.단백질은 핵 국재 배열(NLS)을 가지고 있지만, FGF1이 핵에 도달하기 위해 취하는 경로는 불분명하며, 세포 표면 수용체 결합의 모종의 내화 및 핵으로의 전이가 필요한 것으로 보이며, 이에 따라 FGFRs의 [10]핵 동소 형태와 상호작용할 수 있다.이것은 핵 FGFR을 활성화 할 수 있지만 세포에서 나오지 않고 핵으로 직접 가는 단백질의 스플라이싱 변형을 가지고 있는 FGF2와는 다르다.
기능.
FGF 패밀리는 광범위한 유사분열 및 세포 생존 활동을 가지고 있으며 배아 발달, 세포 성장, 형태 형성, 조직 복구, 종양 성장 및 침입을 포함한 다양한 생물학적 과정에 관여합니다.이 단백질은 혈관신생인자뿐만 아니라 내피세포 이동 및 증식의 수식인자로 기능한다.체외에서 다양한 중배엽 및 신경외배엽 유래 세포에 대한 승모원 역할을 하므로 장기 형성에 관여하는 것으로 생각된다.서로 다른 Isoform을 코드하는 세 가지 대체 스플라이스 변형이 [11]설명되었습니다.
FGF1은 다기능성이며 여러 가지 효과가 보고됩니다.예를 들어, 식이요법 유도 당뇨병을 가진 생쥐의 경우, 인간의 제2형 당뇨병과 실험적으로 동등한 FGF1 단백질을 한 번 주입하면 혈당 수치를 > [12]2일 동안 건강한 범위로 회복시키기에 충분하다.
상호 작용
FGF1은 다음과 상호작용하는 것으로 나타났습니다.
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레퍼런스
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추가 정보
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