슬램F1
SLAMF1
신호 림프구 활성화 분자 1은 인간에서 SLAMF1 유전자에 의해 암호화된 단백질이다.[5][6]최근에는 SLAMF1도 CD150(분화 150 클러스터)으로 지정되었다.
SLAMF1은 신호 림프구 활성화 분자군에 속한다.B세포에서 SLAMF1 유전자의 발현을 위해서는 SLAMF1 추진자와 초기 B-세포 인자 1(EBF1)과의 상호작용이 필요하다.B세포 수용체, 그 공동수용체 및 IL-4R로부터의 신호 전달에 관여하는 STAT6, IRF4 및 NF-kB 인자도 SLAMF1 표현의 규제에 중요한 역할을 한다.[7]
상호작용
SLAMF1은 PTPN11,[8][9] SH2D1A[8][10] 및 SH2D1B와 상호작용하는 것으로 나타났다.[9]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000117090 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000015316 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (August 1995). "A novel receptor involved in T-cell activation". Nature. 376 (6537): 260–3. Bibcode:1995Natur.376..260C. doi:10.1038/376260a0. PMID 7617038. S2CID 4319295.
- ^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1".
- ^ Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.
- ^ a b Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (February 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood. 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999.
- ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (November 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
- ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (September 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
추가 읽기
- Punnonen J, Cocks BG, Carballido JM, Bennett B, Peterson D, Aversa G, de Vries JE (1997). "Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes". J. Exp. Med. 185 (6): 993–1004. doi:10.1084/jem.185.6.993. PMC 2196230. PMID 9091591.
- Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C (1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM". Nature. 395 (6701): 462–9. Bibcode:1998Natur.395..462S. doi:10.1038/26683. PMID 9774102. S2CID 4324402.
- Mikhalap SV, Shlapatska LM, Berdova AG, Law CL, Clark EA, Sidorenko SP (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis". J. Immunol. 162 (10): 5719–27. PMID 10229804.
- Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (2000). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A". Curr. Biol. 9 (23): 1355–62. doi:10.1016/S0960-9822(00)80080-9. PMID 10607564.
- Rogge L, Bianchi E, Biffi M, Bono E, Chang SY, Alexander H, Santini C, Ferrari G, Sinigaglia L, Seiler M, Neeb M, Mous J, Sinigaglia F, Certa U (2000). "Transcript imaging of the development of human T helper cells using oligonucleotide arrays". Nat. Genet. 25 (1): 96–101. doi:10.1038/75671. PMID 10802665. S2CID 5449948.
- Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000). "SLAM (CDw150) is a cellular receptor for measles virus". Nature. 406 (6798): 893–7. Bibcode:2000Natur.406..893T. doi:10.1038/35022579. PMID 10972291. S2CID 4409405.
- Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family". Clin. Immunol. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741.
- Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G, Steinkasserer A (2001). "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta". J. Immunol. 167 (4): 1989–95. doi:10.4049/jimmunol.167.4.1989. PMID 11489980.
- Bleharski JR, Niazi KR, Sieling PA, Cheng G, Modlin RL (2001). "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines". J. Immunol. 167 (6): 3174–81. doi:10.4049/jimmunol.167.6.3174. PMID 11544303.
- Murabayashi N, Kurita-Taniguchi M, Ayata M, Matsumoto M, Ogura H, Seya T (2002). "Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification". Microbes Infect. 4 (8): 785–94. doi:10.1016/S1286-4579(02)01598-8. PMID 12270725.
- Li C, Iosef C, Jia CY, Han VK, Li SS (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
- Hahm B, Arbour N, Naniche D, Homann D, Manchester M, Oldstone MB (2003). "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule". J. Virol. 77 (6): 3505–15. doi:10.1128/JVI.77.6.3505-3515.2003. PMC 149525. PMID 12610126.
- Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
- Ferrand V, Li C, Romeo G, Yin L (2003). "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients". J. Med. Virol. 70 (1): 131–6. doi:10.1002/jmv.10373. PMID 12629654. S2CID 44309832.
- Laaksonen K, Junikka M, Lahesmaa R, Terho EO, Savolainen J (2004). "In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy". J. Allergy Clin. Immunol. 112 (6): 1171–7. doi:10.1016/j.jaci.2003.08.043. PMID 14657878.
외부 링크
