SEMA4D
SEMA4D
세마포린-4D(SEMA4D)는 분화 100 클러스터(Cluster of Dividation 100, CD100)로 알려져 있으며, 인간에서 SEMA4D 유전자에 의해 인코딩되는 세마포린 계열의 단백질이다.[5]
함수
세마포린 4D(Semaphorin 4D, Sema 4D)는 과두화합물로 분비되어 중추신경계에 성장콘 붕괴를 유도하는 액손 유도분자다.플렉신 B1 수용체를 결합하여 R-Ras GTPase 활성 단백질(GAP)의 기능을 하며 성숙한 중추신경계 모두에서 액손 성장 원추(Axon grow cons)를 제거한다.[6]
면역 체계에서 CD100은 CD72를 결합하여 B세포와 덴드리트 세포를 활성화시키지만, 이 상호작용에 대한 많은 것이 아직 조사 중에 있다.[7][8]
피부 손상 수리를 하는 동안 SEMA4D는 감마 델타 T 세포의 플렉신 B2와 상호 작용하여 치유 과정에 역할을 한다.[9]
참고 항목
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000187764 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000021451 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D".
- ^ Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006). "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports. 7 (7): 704–9. doi:10.1038/sj.embor.7400737. PMC 1500830. PMID 16799460.
- ^ Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling". Immunity. 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375.
- ^ Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840.
- ^ Deborah A. Witherden; Megumi Watanabe; Olivia Garijo; Stephanie E. Rieder; Gor Sarkisyan; Shane J.F. Cronin; Petra Verdino; Ian A. Wilson; Atsushi Kumanogoh; Hitoshi Kikutani; Luc Teyton; Wolfgang H. Fischer; Wendy L. Havran (August 2012). "The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function". Immunity. 37 (2): 314–25. doi:10.1016/j.immuni.2012.05.026. PMC 3430606. PMID 22902232.
추가 읽기
- Bougeret C, Mansur IG, Dastot H, et al. (1992). "Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation". J. Immunol. 148 (2): 318–23. PMID 1530858.
- Hall KT, Boumsell L, Schultze JL, et al. (1996). "Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11780–5. Bibcode:1996PNAS...9311780H. doi:10.1073/pnas.93.21.11780. PMC 38135. PMID 8876214.
- Herold C, Elhabazi A, Bismuth G, et al. (1997). "CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion". J. Immunol. 157 (12): 5262–8. PMID 8955171.
- Furuyama T, Inagaki S, Kosugi A, et al. (1997). "Identification of a novel transmembrane semaphorin expressed on lymphocytes". J. Biol. Chem. 271 (52): 33376–81. doi:10.1074/jbc.271.52.33376. PMID 8969198.
- Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
- Elhabazi A, Delaire S, Bensussan A, et al. (2001). "Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis". J. Immunol. 166 (7): 4341–7. doi:10.4049/jimmunol.166.7.4341. PMID 11254687.
- Delaire S, Billard C, Tordjman R, et al. (2001). "Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration". J. Immunol. 166 (7): 4348–54. doi:10.4049/jimmunol.166.7.4348. PMID 11254688.
- Vikis HG, Li W, Guan KL (2002). "The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
- Granziero L, Circosta P, Scielzo C, et al. (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes". Blood. 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
- Love CA, Harlos K, Mavaddat N, et al. (2003). "The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D". Nat. Struct. Biol. 10 (10): 843–8. doi:10.1038/nsb977. PMID 12958590. S2CID 24468463.
- Giraudon P, Vincent P, Vuaillat C, et al. (2004). "Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells". J. Immunol. 172 (2): 1246–55. doi:10.4049/jimmunol.172.2.1246. PMID 14707103.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Deaglio S, Vaisitti T, Bergui L, et al. (2005). "CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival". Blood. 105 (8): 3042–50. doi:10.1182/blood-2004-10-3873. PMID 15613544.
- Conrotto P, Valdembri D, Corso S, et al. (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1". Blood. 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.
- Basile JR, Afkhami T, Gutkind JS (2005). "Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway". Mol. Cell. Biol. 25 (16): 6889–98. doi:10.1128/MCB.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
- Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell. Proteomics. 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
- Nkyimbeng-Takwi EH, Chapoval SP (2011). "Biology and function of neuroimmune semaphorins 4A and 4D". Immunol. Res. 50 (1): 10–21. doi:10.1007/s12026-010-8201-y. PMC 3366695. PMID 21203905.
- Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2011). "Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor". BMC Immunol. 12: 30. doi:10.1186/1471-2172-12-30. PMC 3118960. PMID 21595947.
- Shanks K, Nkyimbeng-Takwi EH, Smith EP, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2013). "Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation". Mol. Immunol. 56 (4): 480–7. doi:10.1016/j.molimm.2013.05.228. PMC 3783523. PMID 23911404.
외부 링크
- SEMA4D+단백질,+인간(MesH) 미국 국립 의학 도서관의 의학 과목 제목(MesH)
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