푸디아제팜

Fludiazepam
푸디아제팜
Fludiazepam.svg
Fludiazepam ball-and-stick model.png
임상자료
상명에리스판 (JP, TW)
AHFS/Drugs.com국제 마약 이름
경로:
행정
구강(테이블)
ATC 코드
법적현황
법적현황
약동학 데이터
신진대사간체
배설레날
식별자
  • 7-클로로페닐-2-1-메틸-1,3-디히드로-2H-1,4-벤조디아제핀-2-1
CAS 번호
펍켐 CID
드러그뱅크
켐스파이더
유니
케그
체비
켐벨
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C16H12CLFN2O
어금질량302.7 g·190−1
3D 모델(JSmol)
  • O=C1CN=C(C2=CC=C2F)C3=CC(Cl)=CC3N1C
  • InChi=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3 checkY
  • 키:RoyoyTLGDLGBX-UHFFFAOYSA-N checkY
(iii)

에리스판(Erispan, エリスパ)[2][3]이라는 브랜드명으로 시판된 [1]푸디아제팜은 1960년대 호프만-라 로슈가 개발한 [4]디아제팜의 강력한 벤조디아제핀과 2ʹ-플루오로 파생상품이다.[5] 일본대만에서 판매되고 있다.[citation needed] GABAergic 억제 강화를 통해 약리학적 특성을 발휘한다.[6] 루디아제팜은 디아제팜보다 벤조디아제핀 수용체에 대한 결합 친화력이 4배 높다.[7] 그것은 항불안제,[8][9][10] 항경련제, 진정제, 최면제, 골격근 이완제 특성을 가지고 있다.[11] 루디아제팜은 오락적으로 사용되어 왔다.[12]

참고 항목

참조

  1. ^ 미국 특허 3371085 5-aryl-3h-1,4-벤조디아제핀-2(1h)-one
  2. ^ Su TP, Chen TJ, Hwang SJ, Chou LF, Fan AP, Chen YC (August 2002). "Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000". Zhonghua Yi Xue Za Zhi (Chinese Medical Journal; Free China Ed). 65 (8): 378–91. PMID 12455808.
  3. ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2008-12-29.
  4. ^ Neville GA, Beckstead HD, Shurvell HF (February 1994). "A Fourier transform-Raman and infrared vibrational study of delorazepam, fludiazepam, flurazepam, and tetrazepam". Journal of Pharmaceutical Sciences. 83 (2): 143–51. doi:10.1002/jps.2600830207. PMID 7909552.
  5. ^ 미국 특허 3299053 -ARYL-JH-L,X-벤조디아ZEPIN-Z(LH)-ONES
  6. ^ Tsuchiya T, Fukushima H (April 1978). "Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons". European Journal of Pharmacology. 48 (4): 421–4. doi:10.1016/0014-2999(78)90169-3. PMID 648585.
  7. ^ Nakatsuka I, Shimizu H, Asami Y, Katoh T, Hirose A, Yoshitake A (January 1985). "Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity". Life Sciences. 36 (2): 113–9. doi:10.1016/0024-3205(85)90089-X. PMID 2857046.
  8. ^ Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1994). "Effect of an anxiolytic on lipid profile in non-insulin-dependent diabetes mellitus". The Journal of International Medical Research. 22 (6): 338–42. doi:10.1177/030006059402200605. PMID 7895897. S2CID 9591519.
  9. ^ Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1995). "Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes". The Journal of International Medical Research. 23 (2): 119–22. doi:10.1177/030006059502300205. PMID 7601294. S2CID 12865838.
  10. ^ Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1995). "How blood pressure in patients with non-insulin-dependent diabetes mellitus is influenced by stress". The Journal of International Medical Research. 23 (5): 377–80. doi:10.1177/030006059502300508. PMID 8529781. S2CID 42485678.
  11. ^ Inoue H, Maeno Y, Iwasa M, Matoba R, Nagao M (September 2000). "Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry". Forensic Science International. 113 (1–3): 367–73. doi:10.1016/S0379-0738(00)00226-7. PMID 10978650.
  12. ^ Shimamine M, Masunari T, Nakahara Y (1993). "[Studies on identification of drugs of abuse by diode array detection. I. Screening-test and identification of benzodiazepines by HPLC-DAD with ICOS software system]". Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences (111): 47–56. PMID 7920567.

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