TWIK 관련 척수칼륨채널 (TRESK) 또는 K182P .1 로도 알려진 칼륨채널 서브패밀리 K18 (KCNK18)은 KCNK18 유전자에 의해 인체 내에서 암호화되는 단백질 이다. K182P .1은 2개의 모공형성 P [5] 도메인을 포함하는 칼륨 채널이다.
이 유전자의 결함은 편두통을 유발 하는데 도움을 줄 수 있다. 만약 유전자가 제대로 작동하지 않는다면, 환경적인 요소들은 뇌의 통증 중심을 더 쉽게 유발하고 심각한 [6] 두통을 일으킬 수 있다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000186795 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040901 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels" . Pharmacol. Rev . 57 (4): 527–40. doi :10.1124/pr.57.4.12 . PMID 16382106 . S2CID 7356601 . ^ Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine . 16 (10): 1157–1160. doi :10.1038/nm.2216 . PMID 20871611 . S2CID 205387180 .
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