KCN4 식별자 별칭 KCN4 외부 ID OMIM : 602754 MGI : 1277957 HomoloGene : 1696 GeneCard : KCNN4 직교체 종 인간 마우스 엔트레스 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 위치(UCSC) Cr 19: 43.77 – 43.78Mb Cr 7: 24.07 – 24.09Mb PubMed 검색[3] [4] 위키다타
칼륨 중/소형 전도 칼슘 활성 채널, 서브 패밀리 N, 멤버 4(KCN4 라고도 함)는 K3Ca .1 단백질 을 인코딩하는 인간 유전자 다.[5]
함수 K3Ca .1 단백질은 세포내 칼슘 에 의해 활성화되는 잠재적으로 이질적 전압 독립성 칼륨 채널의 일부다. 활성화에 이어 막과극화가 진행돼 칼슘 유입이 촉진된다. 인코딩된 단백질은 T-림프세포 에서 칼슘 활성 칼륨 채널 의 일부일 수 있다. 이 유전자는 다른 KCNN 계열 칼륨 채널 유전자와 유사하지만, 새로운 하위 계열의 일부로 간주될 만큼 충분히 다르다.[5]
역사 이 채널 활동은 1958년 Györgh Gardos 에 의해 인간 홍반 에서 처음 설명되었다.[6] 이 채널들은 또한 발견자 때문에 가르도스 채널로 명명된다.
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Chem . 279 (15): 15531–40. doi :10.1074/jbc.M400069200 PMID 14754884 . Gibson JS, Muzyamba MC (2004). "Modulation of Gardos channel activity by oxidants and oxygen tension: effects of 1-chloro-2,4-dinitrobenzene and phenazine methosulphate". Bioelectrochemistry . 62 (2): 147–52. doi :10.1016/j.bioelechem.2003.07.008 . PMID 15039018 . Lew VL, Tiffert T, Etzion Z, Perdomo D, Daw N, Macdonald L, Bookchin RM (2005). "Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells" . Blood . 105 (1): 361–7. doi :10.1182/blood-2004-01-0125 PMID 15339840 . 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
