GPR114

GPR114
ADGRG5
식별자
에일리어스ADGRG5, PGR27, GPR114, 접착성 G단백질결합수용체 G5
외부 IDOMIM: 616965 MGI: 2685955 HomoloGene: 17828 GeneCard: ADGRG5
맞춤법
종.인간마우스
엔트레즈

221188

382045

앙상블

ENSG00000159618

ENSMUSG000061577

유니프로트

Q8IZF4

Q3V3Z3

RefSeq(mRNA)

NM_001304376
NM_153837
NM_001318481

NM_001033468
NM_001145972

RefSeq(단백질)

NP_001291305
NP_001305410
NP_722579

NP_001028640
NP_001139444

장소(UCSC)Chr 16: 57.54 ~57.59 MbChr 8: 95.65 ~95.67 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

G단백질결합수용체 114는 ADGRG5 [5][6][7]유전자에 의해 코드된 단백질이다.GPR114는 접착성 GPCR [8][9]패밀리의 구성원이다.접착성 GPCR은 GPCR-Autoproteolysis INducing([10]GAIN) 도메인으로 알려진 도메인을 통해 TM7 영역에 연결된 N 말단 단백질 모듈을 갖는 확장된 세포외 영역에 의해 특징지어진다.

GPR114 mRNA는 사람 호산구뿐만 아니라 마우스 림프구, 단구, 대식세포,[11] 수지상세포에서 특이적으로 발현된다.

시그널링

HEK293 세포를 과도하게 발현시키는 고리형 아데노신 일인산(cAMP) 분석 결과 GPR114와 Gαs 단백질의 [12]결합이 확인되었다.

레퍼런스

  1. ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000159618 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000061577 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR114 G protein-coupled receptor 114".
  6. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
  7. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  8. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
  9. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
  10. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  11. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  12. ^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–9. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. S2CID 3020230.

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