5-HT1F 수용체

HTR1F
식별자
별칭	HTR1F, 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77, 5-HT1F 수용체, 5-HT1F 수용체 1F
외부 ID	OMIM: 182134 MGI: 99842 HomoloGene: 37361 GeneCard: HTR1F
유전자 위치(인간)
쳇.	3번 염색체(인간)
끝	87,993,839 bp
유전자 위치(마우스)
쳇.	16번 염색체(쥐)
끝	65,165,854 bp
RNA 표현 패턴
	표현된 상단
	랑게르한스 섬; ; 아킬레스건; ; 콩팥을; ; 전두엽 피질; ; 상전두회; ; 골수; ; 피하 지방 조직; ; 위두근; ; 매끄러운 근육 조직;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	G 단백질 결합 수용체 활성; 신호 변환기 활동; 세로토닌 결합; G 단백질 결합 세로토닌 수용체 활성; 신경전달물질 수용체 활성;
셀룰러 컴포넌트	막의 적분 성분; 플라즈마 막; 플라스마 막의 적분 성분; 막으로 막다; 덴드라이트;
생물학적 과정	G 단백질 결합 수용체 신호 경로, 주기적 뉴클레오티드 두 번째 메신저와 결합; 아데닐레이트 사이클라아제 인히비트 G 단백질 결합 수용체 신호 경로; 신호 전달; 화학 시냅스 전달; G 단백질 결합 세로토닌 수용체 신호 경로; G 단백질 결합 수용체 신호 경로;
	출처:아미고 / 퀵고
직교체
	3355
	15557
	ENSG00000179097
	ENSMUSG00000050783
	P30939
	Q02284년
	NM_000866; NM_00138; NM_0013 리볼버9; NM_001322210
	NM_008310
	NP_000857; NP_001309137; NP_001309138; NP_001309139
	NP_032336
	위키다타
인간 보기/편집	마우스 보기/편집

HTR1F라고도 알려진 5-히드록시트리프타민(serotin) 수용체₁ 1F는 5-HT 수용체 단백질이며 이를 인코딩하는 인간 유전자를 나타내기도 한다.^[5]^[6]^[7]^[8]^[9]

고민자

5-n-Butyryloxy-DMT:^[10] >60배 선택성 대 5-HT_1E 수용체
BRL-5443 - 혼합 5-HT_1E/1F 작용제
Eletriptan - 혼합 5-HT_{1B/1D/1E/1F/2B/7} 작용제
LY-334,370^[11] - 관련 벤자미드^[12]
LY-344,864(N-[(3R)-3-(디메틸아미노)-2,3,4,9-테트라하이드로-1H-카르바졸-6-yl]-4-플루오벤츠아미드)
나라트립탄 - 혼합 5-HT_1B/1D/1F 작용제
라스미디탄 - 선택적 5-HT_1F 작용제, 동급 최초의 다이탄 분자

반목자

MLS000756415^[13]

참고 항목

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000179097 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000050783 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".
^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.
^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.
^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.
^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
^ Klein MT, Dukat M, Glennon RA, Teitler M (Jun 2011). "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships". The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860–7. doi:10.1124/jpet.111.179606. PMC 3101003. PMID 21422162.
^ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (Mar 2005). "[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn-Schmiedeberg's Archives of Pharmacology. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510. S2CID 2230855.
^ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (Dec 2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorganic & Medicinal Chemistry Letters. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.
^ PudChem: MLS000756415

추가 읽기

Hoyer D, Hannon JP, Martin GR (Apr 2002). "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacology Biochemistry and Behavior. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546. S2CID 25543069.
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacology & Therapeutics. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
Amlaiky N, Ramboz S, Boschert U, Plassat JL, Hen R (Oct 1992). "Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus". The Journal of Biological Chemistry. 267 (28): 19761–4. doi:10.1016/S0021-9258(19)88617-9. PMID 1328180.
Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.
Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.
Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL (Aug 2004). "Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors". The Journal of Biological Chemistry. 279 (33): 34614–23. doi:10.1074/jbc.M404673200. PMID 15190056.
Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kääriäinen H, Kere J (Oct 2005). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia". PLOS Genetics. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMC 1270007. PMID 16254601.

외부 링크

"5-HT_1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
UCSC 게놈 브라우저의 인간 HTR1F 게놈 위치 및 HTR1F 유전자 세부 정보 페이지.

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

이 투과성 수용체 관련 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000179097 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000050783 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".

[pmid8380639-6] Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.

[pmid8384716-7] Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.

[pmid9394293-8] Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.

[pmid9632173-9] Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.

[10] Klein MT, Dukat M, Glennon RA, Teitler M (Jun 2011). "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships". The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860–7. doi:10.1124/jpet.111.179606. PMC 3101003. PMID 21422162.

[pmid15900510-11] Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (Mar 2005). "[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn-Schmiedeberg's Archives of Pharmacology. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510. S2CID 2230855.

[pmid15546719-12] Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (Dec 2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorganic & Medicinal Chemistry Letters. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.

[13] PudChem: MLS000756415

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5-HT1F 수용체

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