프리즐드-2 는 인간에게 FZD2 유전자에 의해 암호화 되는 단백질이다.[5] [6] [7]
'frizzzed' 유전자 계열의 구성원들은 Wnt 신호 단백질의 수용기인 7-transmbrane 영역 단백질을 암호화한다. FZD2 유전자의 발현은 태아 신장과 폐, 성인 대장 및 난소에서 발현량이 높은 등 발달적으로 조절되는 것으로 보인다.[7]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000180340 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000050288 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics . 27 (2): 370–3. doi :10.1006/geno.1995.1060 . PMID 7558010 . ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun . 252 (1): 117–22. doi :10.1006/bbrc.1998.9607 . PMID 9813155 . ^ a b "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)" .
추가 읽기 Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled" . J. Biol. Chem . 271 (8): 4468–76. doi :10.1074/jbc.271.8.4468 PMID 8626800 . Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action" . Proc. Natl. Acad. Sci. U.S.A . 94 (13): 6770–5. Bibcode :1997PNAS...94.6770F . doi :10.1073/pnas.94.13.6770 PMC 21233 PMID 9192640 . Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals" . Proc. Natl. Acad. Sci. U.S.A . 95 (17): 10164–9. Bibcode :1998PNAS...9510164T . doi :10.1073/pnas.95.17.10164 PMC 21479 PMID 9707618 . Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett . 521 (1–3): 185–9. doi :10.1016/S0014-5793(02)02831-4 . PMID 12067714 . S2CID 39243103 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway" . Genes Cells . 8 (7): 645–54. doi :10.1046/j.1365-2443.2003.00662.x PMID 12839624 . S2CID 40902391 . Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet . 25 (2): 81–90. doi :10.1080/13816810490514270 . PMID 15370539 . S2CID 32817238 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . 외부 링크 "Frizzled Receptors: FZD2 " . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology.이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
