호모 사피엔스 종의 단백질 코드 유전자
G단백질결합수용체12 는 GPR12유전자 에 [5] [6] [7] 단백질 이다.
GPR12의 유전자 산물은 고아 수용체이며, 이는 내인성 배위자 가 현재 알려져 있지 않음을 의미한다. 생쥐의 GPR12 유전자 교란은 이상지질혈증 과 [8]
리간드 역작용제 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000132975 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041468 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system" . FEBS Letters . 336 (2): 317–22. doi :10.1016/0014-5793(93)80828-I PMID 8262253 . S2CID 31345248 . ^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors" . Genomics . 28 (2): 347–9. doi :10.1006/geno.1995.1154 . PMID 8530049 . ^ "Entrez Gene: GPR12 G protein-coupled receptor 12" .^ Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications . 348 (2): 359–66. doi :10.1016/j.bbrc.2006.07.090 . PMID 16887097 . ^ Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12" . Biochemical and Biophysical Research Communications . 493 (1): 451–454. doi :10.1016/j.bbrc.2017.09.001 . PMC 5849771 PMID 28888984 .
추가 정보 Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry . 13 (2): 75–84. doi :10.1159/000070251 . PMID 12649592 . S2CID 45156405 .
